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anti-Human PKC alpha Antibodies:
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Chicken Monoclonal PKC alpha Primary Antibody for IF, IP - ABIN967750
Fujino, Wu, Lin, Phillips, Nedivi: cpg15 and cpg15-2 constitute a family of activity-regulated ligands expressed differentially in the nervous system to promote neurite growth and neuronal survival. in The Journal of comparative neurology 2008
Show all 6 references for ABIN967750
Human Polyclonal PKC alpha Primary Antibody for EIA, IHC (p) - ABIN359058
Rabinovitz, Tsomo, Mercurio: Protein kinase C-alpha phosphorylation of specific serines in the connecting segment of the beta 4 integrin regulates the dynamics of type II hemidesmosomes. in Molecular and cellular biology 2004
Show all 5 references for ABIN359058
Human Polyclonal PKC alpha Primary Antibody for EIA, WB - ABIN453789
Rider, Vandamme, Lebeau, Vertommen, Vidal, Rousseau, Vandekerckhove, Hue: The two forms of bovine heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase result from alternative splicing. in The Biochemical journal 1992
Show all 2 references for ABIN453789
Human Polyclonal PKC alpha Primary Antibody for FACS, IF - ABIN391001
Jaafar, Zeiller, Pirola, Di Grazia, Naro, Vidal, Lefai, Némoz: Phospholipase D regulates myogenic differentiation through the activation of both mTORC1 and mTORC2 complexes. in The Journal of biological chemistry 2011
Human Polyclonal PKC alpha Primary Antibody for IHC, ELISA - ABIN1531462
Huang, Cheng, Su, Lin: Syndecan-4 Promotes Epithelial Tumor Cells Spreading and Regulates the Turnover of PKC? Activity under Mechanical Stimulation on the Elastomeric Substrates. in Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2015
apically localized serine/threonine kinase aPKC directly phosphorylates an N-terminal site of the cell-cycle inhibitor (show CDKN2A Antibodies) p27Xic1 and reduces its ability to inhibit the cyclin-dependent kinase 2 (show CDK2 Antibodies), leading to shortening of G1 and S phases
Neural induction by Syn4 (show SNTG1 Antibodies) through the PKC (show PKC Antibodies) pathway requires inhibition of PKCdelta (show PKCd Antibodies) and activation of PKCalpha.
The depletion of membrane PIP(2) underlies receptor-mediated inhibition of IKs and that phosphorylation by PKC (show PKC Antibodies) of the KCNE1 (show KCNE1 Antibodies) subunit underlies the GqPCR-mediated channel activation.
Our data demonstrate isoform-specific regulation of closed-state inactivation by protein kinase C (show PKC Antibodies) in Kv4.3 (show KCND3 Antibodies)
Data show that PKC staining colocalizes with monkey retina expresses a retina-specific slice variant of PCP2.
PKCalpha activity was effectively suppressed by the PKC inhibitor.
this study shows that the mTOR inhibitors suppression of invasion and migration of glioblastoma cells is mediated by reduction of PKC-alpha activity and downregulation of NFkappaB
PKCalpha controls HIF-1alpha (show HIF1A Antibodies) translation via AKT (show AKT1 Antibodies)-mTOR (show FRAP1 Antibodies) under hypoxic conditions.
Our results provide compelling evidence that glucose-induced PKCalpha/PKCbeta-mediated inhibition of Kv current in vascular smooth muscle causes an enhanced constrictor response. Inhibition of Kv current causes a significant depolarization of vascular myocytes leading to marked vasoconstriction
Data suggest that targeted manipulation of protein kinase C (show PKC Antibodies) isoforms PKCalpha, PKCbeta, and PKCeta might be beneficial in certain proteinuric kidney diseases with altered transient receptor potential cation channel subfamily C member 6 (show TRPC6 Antibodies) protein (TRPC6 (show TRPC6 Antibodies)) functions.
Kinocilium is essential for proper localization of Lgn, as well as Gai and aPKC, suggesting that cilium function plays a role in positioning of apical proteins critical for hearing.
PKCalpha Attenuates Jagged-1 (show JAG1 Antibodies)-Mediated Notch (show NOTCH1 Antibodies) Signaling in ErbB-2 (show ERBB2 Antibodies)-Positive Breast Cancer to Reverse Trastuzumab Resistance
we suggest that PKCA tightly controls TRM6/61 activity to prevent translation deregulation that would favor neoplastic development.
Prolonged membrane association/activation of PKCalpha is seen in self-renewing epithelium of the intestine, cervix, and skin.
RNA sequencing identified a novel ATPase (show DNAH8 Antibodies), Ca2 (show CA2 Antibodies)+ transporting, plasma membrane 4(ATP2B4 (show ATP2B4 Antibodies))-protein kinase C-alpha (PRKCA) fusion transcript.
We conclude that synaptotagmin-1 (show SYT1 Antibodies) phosphorylation is an essential step in PKC (show PKC Antibodies)-dependent potentiation of synaptic transmission, acting downstream of the two other essential DAG/PKC (show PKC Antibodies) substrates, Munc13-1 (show UNC13A Antibodies) and Munc18-1 (show STXBP1 Antibodies).
These data indicate that LPA increases CCN2 (show CTGF Antibodies) expression through the activation of PKC (show PKC Antibodies) and PKA. Thus, the regulatory functions of the PKC (show PKC Antibodies) and PKA pathways are implicated in the LPA-induced increase in CCN2 (show CTGF Antibodies) expression
We conclude that melatonin, via modulation of PKC (show PKC Antibodies) and Ca(2 (show CA2 Antibodies)+) signaling, could potentially stimulate the Nrf2 (show NFE2L2 Antibodies)-mediated antioxidant response in mouse pancreatic acinar cells.
PKCalpha deficiency leads to pulmonary vascular hyperresponsiveness to TXA2 (show TBXA2R Antibodies), possibly via increased pulmonary arterial TP receptor (show TBXA2R Antibodies) expression.
at the functionally mature calyx of Held synapse the Ca(2 (show CA2 Antibodies)+)-dependent protein kinase C (show PKC Antibodies) isoforms alpha and beta are necessary for post-tetanic potentiation, a form of plasticity thought to underlie short-term memory
PKC gene deletion is responsible for hair loss.
The overall result suggests the cancer preventive activity of quercetin via the induction of apoptosis and modulates PKC signaling with the reduction of oxidative stress in ascite cells of lymphoma-bearing mice.
the ANG II (show AGT Antibodies)-dependent upregulation of renin (show REN Antibodies) in the collecting duct depends on PKC-alpha, which allows the augmentation of cAMP production and activation of PKA/CREB (show CREB1 Antibodies) pathway
role for PKCalpha in the regulation of ECM (show MMRN1 Antibodies) structure and deposition during skin wound healing.
PKC (show PKC Antibodies) activation can enhance hippocampal neurotransmitter release, depending on changes specific to mGluR5 (show GRM5 Antibodies) and AMPA (show GRIA3 Antibodies)/kainate receptors.
Isoenzymes beta and delta of PKC have been found significantly phosphorylated, although their location was not changed as a consequence of Trichinella spiralis infection.
AngII activates PKD via a mechanism involving Src family kinases and PKC, to underlie increased aldosterone production.
Significant changes in thin filament Ca2 (show CA2 Antibodies)+-sensitivity, structure and kinetics are brought about through PKC (show PKC Antibodies) phosphorylation of cardiac troponin T (show TNNT2 Antibodies).
Data indicate the involvement of PKC-alpha in proMMP-2 activation and inhibition of TIMP-2 (show TIMP2 Antibodies) expression by NF-kappaB (show NFKB1 Antibodies)-MT1-MMP (show MMP14 Antibodies)-dependent and -independent pathway.
calcium-dependent phosphorylation of argininosuccinate synthase (show ASS1 Antibodies) Ser (show SIGLEC1 Antibodies)-328 is mediated by PKCalpha
VDAC phosphorylation is an important determinant of its interaction with dimeric tubulin (show TUBB Antibodies).
Using yeast cells co-expressing the human wild-type p53 and a single mammalian PKCalpha, delta, epsilon or zeta, results showed a differential regulation of p53-mediated apoptosis by these PKC isoforms.
degradation of protein kinase C(alpha)in sperm capacitation is mediated by PRKA (show Akap6 Antibodies)
Data suggest that ceramide interacts with the calcium-dependent lipid binding C2 domain of protein kinase C alpha and thereby induces translocation of the enzyme to the Golgi compartment.
analysis of amino acid critical for the catalytic competence and function of protein kinase (show CDK7 Antibodies) Calpha (show PRKACA Antibodies)
By regulating VEGFR2 (show KDR Antibodies) expression and activation, PKC-epsilon (show PRKCE Antibodies) expression is critical for activation of Akt (show AKT1 Antibodies) and eNOS (show NOS3 Antibodies) by VEGF (show VEGFA Antibodies) and contributes to VEGF (show VEGFA Antibodies)-stimulated Erk (show MAPK1 Antibodies) activation, whereas PKC-alpha has opposite effects.
We conclude that ouabain, even at low concentrations (0.5-8.0 mum), can increase INaL and reverse INCX , and these effects may contribute to the effect of the glycoside to increase Ca(2 (show CA2 Antibodies)+) transients and contractility.
These results suggest a complex antagonistic interplay between G(q)-activated PKC and Gbetagamma in regulation of L-VDCC, in which multiple cytosolic segments of alpha(1C) are involved.
Protein kinase C alpha (PKCalpha) regulates growth and invasion of endometrial cancer cells.
This study examined the protein expression and spatial-temporal distribution of PKCalpha and CPI-17 (show PPP1R14A Antibodies) in intact smooth muscle tissues.
Results suggest that the action of genistein on protein kinase A is mediated via adenylate cyclase, but does not appear to involve Gs protein or ICI 182780-sensitive estrogen receptor (show ESR1 Antibodies).
The PKCalpha, PKCbeta1, and PKCbeta2 mRNA levels tended to be lower in ischemia-reperfused than in sham-operated eyes in both the retinal arteries and the neuroretina.
protein level of retinal PKC-alpha is increased with maturation
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes.
, protein kinase C alpha type
, protein kinase C, alpha
, protein kinase C alpha type-like
, aging-associated gene 6
, protein kinase c-alpha
, protein kinase, C alpha
, protein kinase C alpha