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Browse our anti-PKC alpha (PKCa) Antibodies

Full name:
anti-Protein Kinase C, alpha Antibodies (PKCa)
On are 247 Protein Kinase C, alpha (PKCa) Antibodies from 28 different suppliers available. Additionally we are shipping PKC alpha Kits (42) and PKC alpha Proteins (17) and many more products for this protein. A total of 317 PKC alpha products are currently listed.
AAG6, AI875142, im:7139045, LOC100219195, PKC-alpha, Pkca, pkcalpha, PKRCA, PRKACA, si:dkey-8l19.1
list all antibodies Gene Name GeneID UniProt
PKCa 5578 P17252
PKCa 18750 P20444
PKCa 24680  

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Most Popular Reactivities for anti-PKC alpha (PKCa) Antibodies

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anti-Human PKC alpha Antibodies:

anti-Mouse (Murine) PKC alpha Antibodies:

anti-Rat (Rattus) PKC alpha Antibodies:

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Top referenced anti-PKC alpha Antibodies

  1. Chicken Monoclonal PKC alpha Primary Antibody for IF, IP - ABIN967750 : Fujino, Wu, Lin, Phillips, Nedivi: cpg15 and cpg15-2 constitute a family of activity-regulated ligands expressed differentially in the nervous system to promote neurite growth and neuronal survival. in The Journal of comparative neurology 2008 (PubMed)
    Show all 6 references for ABIN967750

  2. Human Polyclonal PKC alpha Primary Antibody for EIA, IHC (p) - ABIN359058 : Rabinovitz, Tsomo, Mercurio: Protein kinase C-alpha phosphorylation of specific serines in the connecting segment of the beta 4 integrin regulates the dynamics of type II hemidesmosomes. in Molecular and cellular biology 2004 (PubMed)
    Show all 5 references for ABIN359058

  3. Human Polyclonal PKC alpha Primary Antibody for EIA, WB - ABIN453789 : Rider, Vandamme, Lebeau, Vertommen, Vidal, Rousseau, Vandekerckhove, Hue: The two forms of bovine heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase result from alternative splicing. in The Biochemical journal 1992 (PubMed)
    Show all 2 references for ABIN453789

  4. Human Polyclonal PKC alpha Primary Antibody for FACS, IF - ABIN391001 : Jaafar, Zeiller, Pirola, Di Grazia, Naro, Vidal, Lefai, Némoz: Phospholipase D regulates myogenic differentiation through the activation of both mTORC1 and mTORC2 complexes. in The Journal of biological chemistry 2011 (PubMed)

  5. Human Polyclonal PKC alpha Primary Antibody for IHC, ELISA - ABIN1531462 : Huang, Cheng, Su, Lin: Syndecan-4 Promotes Epithelial Tumor Cells Spreading and Regulates the Turnover of PKC? Activity under Mechanical Stimulation on the Elastomeric Substrates. in Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2015 (PubMed)

More Antibodies against PKC alpha Interaction Partners

Xenopus laevis Protein Kinase C, alpha (PKCa) interaction partners

  1. apically localized serine/threonine kinase aPKC directly phosphorylates an N-terminal site of the cell-cycle inhibitor (show CDKN2A Antibodies) p27Xic1 and reduces its ability to inhibit the cyclin-dependent kinase 2 (show CDK2 Antibodies), leading to shortening of G1 and S phases

  2. Neural induction by Syn4 (show SNTG1 Antibodies) through the PKC (show PKC Antibodies) pathway requires inhibition of PKCdelta (show PKCd Antibodies) and activation of PKCalpha.

  3. The depletion of membrane PIP(2) underlies receptor-mediated inhibition of IKs and that phosphorylation by PKC (show PKC Antibodies) of the KCNE1 (show KCNE1 Antibodies) subunit underlies the GqPCR-mediated channel activation.

  4. Our data demonstrate isoform-specific regulation of closed-state inactivation by protein kinase C (show PKC Antibodies) in Kv4.3 (show KCND3 Antibodies)

Rhesus Monkey Protein Kinase C, alpha (PKCa) interaction partners

  1. Data show that PKC staining colocalizes with monkey retina expresses a retina-specific slice variant of PCP2.

Human Protein Kinase C, alpha (PKCa) interaction partners

  1. we suggest that PKCA tightly controls TRM6/61 activity to prevent translation deregulation that would favor neoplastic development.

  2. Prolonged membrane association/activation of PKCalpha is seen in self-renewing epithelium of the intestine, cervix, and skin.

  3. RNA sequencing identified a novel ATPase (show DNAH8 Antibodies), Ca2 (show CA2 Antibodies)+ transporting, plasma membrane 4(ATP2B4 (show ATP2B4 Antibodies))-protein kinase C-alpha (PRKCA) fusion transcript.

  4. InB may exhibit growth-inhibitory activity through the activation of PKCalpha, followed by an increase in NFAT (show NFATC1 Antibodies) transactivation ability.

  5. High P-PKCalpha expression in neoplastic gastric cancer biopsy samples as compared to nonneoplastic samples suggests that P-PKCalpha might act as an indicator of gastric cancer progression.

  6. Data show that bisindolylmaleimides (BIMs) Ro 31-8220 also blocks activity of the solute carrier (show SERTAD2 Antibodies) organic cation transporter 1 (OCT1), involved in uptake of marketed drugs in the liver, in a protein kinase C (PKC (show PKC Antibodies))-independent manner.

  7. this study identified PKC (show PRRT2 Antibodies) as the kinase that phosphorylates a specific site in the linker region of PACSIN2 (show PACSIN2 Antibodies).

  8. results indicate that PKC (show PRRT2 Antibodies)-mediated cortactin (show CTTN Antibodies) phosphorylation might be implicated in the maintenance of growth cone

  9. This study showed that SLC44A1 (show SLC44A1 Antibodies)-PRKCA fusion seems to be a specific characteristic of Papillary glioneuronal tumors with a high diagnostic value.

  10. Syndecan-4 is essential for transmitting the mechanotransduction signals via activation of PKC-alpha and is important for tumor cells spreading, assembly of actin cytoskeleton and cell contractility.

Mouse (Murine) Protein Kinase C, alpha (PKCa) interaction partners

  1. We conclude that melatonin, via modulation of PKC (show PKC Antibodies) and Ca(2 (show CA2 Antibodies)+) signaling, could potentially stimulate the Nrf2 (show NFE2L2 Antibodies)-mediated antioxidant response in mouse pancreatic acinar cells.

  2. PKCalpha deficiency leads to pulmonary vascular hyperresponsiveness to TXA2 (show TBXA2R Antibodies), possibly via increased pulmonary arterial TP receptor (show TBXA2R Antibodies) expression.

  3. at the functionally mature calyx of Held synapse the Ca(2 (show CA2 Antibodies)+)-dependent protein kinase C (show PKC Antibodies) isoforms alpha and beta are necessary for post-tetanic potentiation, a form of plasticity thought to underlie short-term memory

  4. PKC gene deletion is responsible for hair loss.

  5. The overall result suggests the cancer preventive activity of quercetin via the induction of apoptosis and modulates PKC signaling with the reduction of oxidative stress in ascite cells of lymphoma-bearing mice.

  6. the ANG II (show AGT Antibodies)-dependent upregulation of renin (show REN Antibodies) in the collecting duct depends on PKC-alpha, which allows the augmentation of cAMP production and activation of PKA/CREB (show CREB1 Antibodies) pathway

  7. role for PKCalpha in the regulation of ECM (show MMRN1 Antibodies) structure and deposition during skin wound healing.

  8. A dynamic PKC (show PKC Antibodies) phosphorylation/de-phosphorylation cycle of Munc18-1 (show STXBP1 Antibodies) drives short-term enhancement of transmitter release during post-tetanic potentiation.

  9. PKC-alpha and -delta have been shown to play crucial role in cardiac adaptation during physiological and pathological hypertrophy respectively thereby rendering compromised cardiac function to an otherwise efficient heart by conditional reversal of activation.

  10. Data show increased expression of T-type Ca(2 (show CA2 Antibodies)+) current and association of protein kinase C alpha (PKCalpha) with caveolin-3 (Cav-3 (show CAV3 Antibodies))was disrupted in the hypertrophic ventricular myocyte.

Cow (Bovine) Protein Kinase C, alpha (PKCa) interaction partners

  1. AngII activates PKD via a mechanism involving Src family kinases and PKC, to underlie increased aldosterone production.

  2. Significant changes in thin filament Ca2 (show CA2 Antibodies)+-sensitivity, structure and kinetics are brought about through PKC (show PKC Antibodies) phosphorylation of cardiac troponin T (show TNNT2 Antibodies).

  3. Data indicate the involvement of PKC-alpha in proMMP-2 activation and inhibition of TIMP-2 (show TIMP2 Antibodies) expression by NF-kappaB (show NFKB1 Antibodies)-MT1-MMP (show MMP14 Antibodies)-dependent and -independent pathway.

  4. calcium-dependent phosphorylation of argininosuccinate synthase (show ASS1 Antibodies) Ser (show SIGLEC1 Antibodies)-328 is mediated by PKCalpha

  5. VDAC phosphorylation is an important determinant of its interaction with dimeric tubulin (show TUBB Antibodies).

  6. Using yeast cells co-expressing the human wild-type p53 and a single mammalian PKCalpha, delta, epsilon or zeta, results showed a differential regulation of p53-mediated apoptosis by these PKC isoforms.

  7. degradation of protein kinase C(alpha)in sperm capacitation is mediated by PRKA (show Akap6 Antibodies)

  8. Data suggest that ceramide interacts with the calcium-dependent lipid binding C2 domain of protein kinase C alpha and thereby induces translocation of the enzyme to the Golgi compartment.

  9. analysis of amino acid critical for the catalytic competence and function of protein kinase (show CDK7 Antibodies) Calpha (show PRKACA Antibodies)

  10. By regulating VEGFR2 (show KDR Antibodies) expression and activation, PKC-epsilon (show PRKCE Antibodies) expression is critical for activation of Akt (show AKT1 Antibodies) and eNOS (show NOS3 Antibodies) by VEGF (show VEGFA Antibodies) and contributes to VEGF (show VEGFA Antibodies)-stimulated Erk (show MAPK1 Antibodies) activation, whereas PKC-alpha has opposite effects.

Rabbit Protein Kinase C, alpha (PKCa) interaction partners

  1. We conclude that ouabain, even at low concentrations (0.5-8.0 mum), can increase INaL and reverse INCX , and these effects may contribute to the effect of the glycoside to increase Ca(2 (show CA2 Antibodies)+) transients and contractility.

  2. These results suggest a complex antagonistic interplay between G(q)-activated PKC and Gbetagamma in regulation of L-VDCC, in which multiple cytosolic segments of alpha(1C) are involved.

  3. Protein kinase C alpha (PKCalpha) regulates growth and invasion of endometrial cancer cells.

Pig (Porcine) Protein Kinase C, alpha (PKCa) interaction partners

  1. This study examined the protein expression and spatial-temporal distribution of PKCalpha and CPI-17 (show PPP1R14A Antibodies) in intact smooth muscle tissues.

  2. Results suggest that the action of genistein on protein kinase A is mediated via adenylate cyclase, but does not appear to involve Gs protein or ICI 182780-sensitive estrogen receptor (show ESR1 Antibodies).

  3. The PKCalpha, PKCbeta1, and PKCbeta2 mRNA levels tended to be lower in ischemia-reperfused than in sham-operated eyes in both the retinal arteries and the neuroretina.

  4. protein level of retinal PKC-alpha is increased with maturation

PKC alpha (PKCa) Antigen Profile

Antigen Summary

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes.

Alternative names and synonyms associated with PKC alpha (PKCa)

  • protein kinase C, alpha (PRKCA) antibody
  • protein kinase C, alpha (prkca) antibody
  • protein kinase C, alpha (LOC100219195) antibody
  • protein kinase C, alpha (Prkca) antibody
  • AAG6 antibody
  • AI875142 antibody
  • im:7139045 antibody
  • LOC100219195 antibody
  • PKC-alpha antibody
  • Pkca antibody
  • pkcalpha antibody
  • PKRCA antibody
  • PRKACA antibody
  • si:dkey-8l19.1 antibody

Protein level used designations for PKCa

pkc-like 2 , protein kinase C alpha type , protein kinase C, alpha , protein kinase C alpha type-like , PKC-A , aging-associated gene 6 , PKC-alpha , protein kinase c-alpha , protein kinase, C alpha , protein kinase C alpha

100063318 Equus caballus
447031 Xenopus laevis
497384 Danio rerio
780209 Xenopus (Silurana) tropicalis
100219195 Taeniopygia guttata
100391814 Callithrix jacchus
718412 Macaca mulatta
100591651 Nomascus leucogenys
5578 Homo sapiens
18750 Mus musculus
24680 Rattus norvegicus
100713627 Cavia porcellus
282001 Bos taurus
417430 Gallus gallus
490904 Canis lupus familiaris
100037720 Oryctolagus cuniculus
397184 Sus scrofa
101110074 Ovis aries
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