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Browse our anti-PKC alpha (PKCa) Antibodies

Full name:
anti-Protein Kinase C, alpha Antibodies (PKCa)
On are 274 Protein Kinase C, alpha (PKCa) Antibodies from 29 different suppliers available. Additionally we are shipping PKC alpha Kits (37) and PKC alpha Proteins (17) and many more products for this protein. A total of 339 PKC alpha products are currently listed.
AAG6, AI875142, im:7139045, LOC100219195, PKC-alpha, Pkca, pkcalpha, PKRCA, PRKACA, si:dkey-8l19.1
list all antibodies Gene Name GeneID UniProt
PKCa 5578 P17252
PKCa 18750 P20444
PKCa 24680  

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All available anti-PKC alpha Antibodies

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Top referenced anti-PKC alpha Antibodies

  1. Cow (Bovine) Monoclonal PKC alpha Primary Antibody for ICC, FACS - ABIN153146 : Cesare, Dekker, Sardini, Parker, McNaughton: Specific involvement of PKC-epsilon in sensitization of the neuronal response to painful heat. in Neuron 1999 (PubMed)
    Show all 13 references for ABIN153146

  2. Chicken Monoclonal PKC alpha Primary Antibody for IF, IP - ABIN967750 : Fujino, Wu, Lin, Phillips, Nedivi: cpg15 and cpg15-2 constitute a family of activity-regulated ligands expressed differentially in the nervous system to promote neurite growth and neuronal survival. in The Journal of comparative neurology 2008 (PubMed)
    Show all 6 references for ABIN967750

  3. Human Polyclonal PKC alpha Primary Antibody for EIA, IHC (p) - ABIN359058 : Rabinovitz, Tsomo, Mercurio: Protein kinase C-alpha phosphorylation of specific serines in the connecting segment of the beta 4 integrin regulates the dynamics of type II hemidesmosomes. in Molecular and cellular biology 2004 (PubMed)
    Show all 5 references for ABIN359058

  4. Human Polyclonal PKC alpha Primary Antibody for EIA, WB - ABIN453789 : Rider, Vandamme, Lebeau, Vertommen, Vidal, Rousseau, Vandekerckhove, Hue: The two forms of bovine heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase result from alternative splicing. in The Biochemical journal 1992 (PubMed)
    Show all 2 references for ABIN453789

  5. Human Polyclonal PKC alpha Primary Antibody for FACS, IF - ABIN391001 : Jaafar, Zeiller, Pirola, Di Grazia, Naro, Vidal, Lefai, Némoz: Phospholipase D regulates myogenic differentiation through the activation of both mTORC1 and mTORC2 complexes. in The Journal of biological chemistry 2011 (PubMed)

  6. Human Polyclonal PKC alpha Primary Antibody for IHC, ELISA - ABIN1531462 : Huang, Cheng, Su, Lin: Syndecan-4 Promotes Epithelial Tumor Cells Spreading and Regulates the Turnover of PKC? Activity under Mechanical Stimulation on the Elastomeric Substrates. in Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2015 (PubMed)

More Antibodies against PKC alpha Interaction Partners

Xenopus laevis Protein Kinase C, alpha (PKCa) interaction partners

  1. apically localized serine/threonine kinase aPKC directly phosphorylates an N-terminal site of the cell-cycle inhibitor (show CDKN2A Antibodies) p27Xic1 and reduces its ability to inhibit the cyclin-dependent kinase 2 (show CDK2 Antibodies), leading to shortening of G1 and S phases

  2. Neural induction by Syn4 (show SNTG1 Antibodies) through the PKC (show PKC Antibodies) pathway requires inhibition of PKCdelta (show PKCd Antibodies) and activation of PKCalpha.

  3. The depletion of membrane PIP(2) underlies receptor-mediated inhibition of IKs and that phosphorylation by PKC (show PKC Antibodies) of the KCNE1 (show KCNE1 Antibodies) subunit underlies the GqPCR-mediated channel activation.

  4. Our data demonstrate isoform-specific regulation of closed-state inactivation by protein kinase C (show PKC Antibodies) in Kv4.3 (show KCND3 Antibodies)

Rhesus Monkey Protein Kinase C, alpha (PKCa) interaction partners

  1. Data show that PKC staining colocalizes with monkey retina expresses a retina-specific slice variant of PCP2.

Human Protein Kinase C, alpha (PKCa) interaction partners

  1. After inhibition of the PKC/ERK signalling pathway, the effects of DOR on breast cancer were significantly attenuated in vivo and in vitro. In summary, DOR is highly expressed in breast cancer and is closely related to its progression. These results suggest that DOR may serve as a potential biomarker for the early diagnosis of breast cancer and may be a viable molecular target for therapeutic intervention.

  2. authors found significant interactions among PRKCA, NOS3 (show NANOS3 Antibodies) and BDKRB2 (show BDKRB2 Antibodies) genotypes associated with enalapril responses.

  3. Protein kinase C alpha (PKCalpha) is able to phosphorylate CK1delta at its C-terminally located residues S328, T329, and S370.

  4. PKCalpha activity was effectively suppressed by the PKC inhibitor.

  5. this study shows that the mTOR inhibitors suppression of invasion and migration of glioblastoma cells is mediated by reduction of PKC-alpha activity and downregulation of NFkappaB

  6. PKCalpha controls HIF-1alpha (show HIF1A Antibodies) translation via AKT (show AKT1 Antibodies)-mTOR (show FRAP1 Antibodies) under hypoxic conditions.

  7. Our results provide compelling evidence that glucose-induced PKCalpha/PKCbeta-mediated inhibition of Kv current in vascular smooth muscle causes an enhanced constrictor response. Inhibition of Kv current causes a significant depolarization of vascular myocytes leading to marked vasoconstriction

  8. Data suggest that targeted manipulation of protein kinase C (show PKC Antibodies) isoforms PKCalpha, PKCbeta, and PKCeta might be beneficial in certain proteinuric kidney diseases with altered transient receptor potential cation channel subfamily C member 6 (show TRPC6 Antibodies) protein (TRPC6 (show TRPC6 Antibodies)) functions.

  9. Kinocilium is essential for proper localization of Lgn, as well as Gai and aPKC, suggesting that cilium function plays a role in positioning of apical proteins critical for hearing.

  10. PKCalpha Attenuates Jagged-1 (show JAG1 Antibodies)-Mediated Notch (show NOTCH1 Antibodies) Signaling in ErbB-2 (show ERBB2 Antibodies)-Positive Breast Cancer to Reverse Trastuzumab Resistance

Mouse (Murine) Protein Kinase C, alpha (PKCa) interaction partners

  1. the present study demonstrates that nNOS-derived NO signaling modulated by spinal Sig-1R activation increases Nox2 activity and concomitant ROS production, which leads to a ROS-induced increase in PKC-dependent pGluN1 expression in the spinal cord dorsal horn and the development of pain hypersensitivity

  2. We conclude that synaptotagmin-1 (show SYT1 Antibodies) phosphorylation is an essential step in PKC (show PKC Antibodies)-dependent potentiation of synaptic transmission, acting downstream of the two other essential DAG/PKC (show PKC Antibodies) substrates, Munc13-1 (show UNC13A Antibodies) and Munc18-1 (show STXBP1 Antibodies).

  3. These data indicate that LPA increases CCN2 (show CTGF Antibodies) expression through the activation of PKC (show PKC Antibodies) and PKA. Thus, the regulatory functions of the PKC (show PKC Antibodies) and PKA pathways are implicated in the LPA-induced increase in CCN2 (show CTGF Antibodies) expression

  4. Kinocilium is essential for proper localization of Lgn, as well as Gai and aPKC, suggesting that cilium function plays a role in positioning of apical proteins critical for hearing.

  5. We conclude that melatonin, via modulation of PKC (show PKC Antibodies) and Ca(2 (show CA2 Antibodies)+) signaling, could potentially stimulate the Nrf2 (show NFE2L2 Antibodies)-mediated antioxidant response in mouse pancreatic acinar cells.

  6. PKCalpha deficiency leads to pulmonary vascular hyperresponsiveness to TXA2 (show TBXA2R Antibodies), possibly via increased pulmonary arterial TP receptor (show TBXA2R Antibodies) expression.

  7. at the functionally mature calyx of Held synapse the Ca(2 (show CA2 Antibodies)+)-dependent protein kinase C (show PKC Antibodies) isoforms alpha and beta are necessary for post-tetanic potentiation, a form of plasticity thought to underlie short-term memory

  8. PKC gene deletion is responsible for hair loss.

  9. The overall result suggests the cancer preventive activity of quercetin via the induction of apoptosis and modulates PKC signaling with the reduction of oxidative stress in ascite cells of lymphoma-bearing mice.

  10. the ANG II (show AGT Antibodies)-dependent upregulation of renin (show REN Antibodies) in the collecting duct depends on PKC-alpha, which allows the augmentation of cAMP production and activation of PKA/CREB (show CREB1 Antibodies) pathway

Guinea Pig Protein Kinase C, alpha (PKCa) interaction partners

  1. PKC (show PKC Antibodies) activation can enhance hippocampal neurotransmitter release, depending on changes specific to mGluR5 (show GRM5 Antibodies) and AMPA (show GRIA3 Antibodies)/kainate receptors.

  2. Isoenzymes beta and delta of PKC have been found significantly phosphorylated, although their location was not changed as a consequence of Trichinella spiralis infection.

Cow (Bovine) Protein Kinase C, alpha (PKCa) interaction partners

  1. AngII activates PKD via a mechanism involving Src family kinases and PKC, to underlie increased aldosterone production.

  2. Significant changes in thin filament Ca2 (show CA2 Antibodies)+-sensitivity, structure and kinetics are brought about through PKC (show PKC Antibodies) phosphorylation of cardiac troponin T (show TNNT2 Antibodies).

  3. Data indicate the involvement of PKC-alpha in proMMP-2 activation and inhibition of TIMP-2 (show TIMP2 Antibodies) expression by NF-kappaB (show NFKB1 Antibodies)-MT1-MMP (show MMP14 Antibodies)-dependent and -independent pathway.

  4. calcium-dependent phosphorylation of argininosuccinate synthase (show ASS1 Antibodies) Ser (show SIGLEC1 Antibodies)-328 is mediated by PKCalpha

  5. VDAC phosphorylation is an important determinant of its interaction with dimeric tubulin (show TUBB Antibodies).

  6. Using yeast cells co-expressing the human wild-type p53 and a single mammalian PKCalpha, delta, epsilon or zeta, results showed a differential regulation of p53-mediated apoptosis by these PKC isoforms.

  7. degradation of protein kinase C(alpha)in sperm capacitation is mediated by PRKA (show Akap6 Antibodies)

  8. Data suggest that ceramide interacts with the calcium-dependent lipid binding C2 domain of protein kinase C alpha and thereby induces translocation of the enzyme to the Golgi compartment.

  9. analysis of amino acid critical for the catalytic competence and function of protein kinase (show CDK7 Antibodies) Calpha (show PRKACA Antibodies)

  10. By regulating VEGFR2 (show KDR Antibodies) expression and activation, PKC-epsilon (show PRKCE Antibodies) expression is critical for activation of Akt (show AKT1 Antibodies) and eNOS (show NOS3 Antibodies) by VEGF (show VEGFA Antibodies) and contributes to VEGF (show VEGFA Antibodies)-stimulated Erk (show MAPK1 Antibodies) activation, whereas PKC-alpha has opposite effects.

Rabbit Protein Kinase C, alpha (PKCa) interaction partners

  1. We conclude that ouabain, even at low concentrations (0.5-8.0 mum), can increase INaL and reverse INCX , and these effects may contribute to the effect of the glycoside to increase Ca(2 (show CA2 Antibodies)+) transients and contractility.

  2. These results suggest a complex antagonistic interplay between G(q)-activated PKC and Gbetagamma in regulation of L-VDCC, in which multiple cytosolic segments of alpha(1C) are involved.

  3. Protein kinase C alpha (PKCalpha) regulates growth and invasion of endometrial cancer cells.

Pig (Porcine) Protein Kinase C, alpha (PKCa) interaction partners

  1. This study examined the protein expression and spatial-temporal distribution of PKCalpha and CPI-17 (show PPP1R14A Antibodies) in intact smooth muscle tissues.

  2. Results suggest that the action of genistein on protein kinase A is mediated via adenylate cyclase, but does not appear to involve Gs protein or ICI 182780-sensitive estrogen receptor (show ESR1 Antibodies).

  3. The PKCalpha, PKCbeta1, and PKCbeta2 mRNA levels tended to be lower in ischemia-reperfused than in sham-operated eyes in both the retinal arteries and the neuroretina.

  4. protein level of retinal PKC-alpha is increased with maturation

PKC alpha (PKCa) Antigen Profile

Antigen Summary

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes.

Alternative names and synonyms associated with PKC alpha (PKCa)

  • protein kinase C, alpha (PRKCA) antibody
  • protein kinase C, alpha (prkca) antibody
  • protein kinase C, alpha (LOC100219195) antibody
  • protein kinase C, alpha (Prkca) antibody
  • AAG6 antibody
  • AI875142 antibody
  • im:7139045 antibody
  • LOC100219195 antibody
  • PKC-alpha antibody
  • Pkca antibody
  • pkcalpha antibody
  • PKRCA antibody
  • PRKACA antibody
  • si:dkey-8l19.1 antibody

Protein level used designations for PKCa

pkc-like 2 , protein kinase C alpha type , protein kinase C, alpha , protein kinase C alpha type-like , PKC-A , aging-associated gene 6 , PKC-alpha , protein kinase c-alpha , protein kinase, C alpha , protein kinase C alpha

100063318 Equus caballus
447031 Xenopus laevis
497384 Danio rerio
780209 Xenopus (Silurana) tropicalis
100219195 Taeniopygia guttata
100391814 Callithrix jacchus
718412 Macaca mulatta
100591651 Nomascus leucogenys
5578 Homo sapiens
18750 Mus musculus
24680 Rattus norvegicus
100713627 Cavia porcellus
282001 Bos taurus
417430 Gallus gallus
490904 Canis lupus familiaris
100037720 Oryctolagus cuniculus
397184 Sus scrofa
101110074 Ovis aries
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