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anti-Human PKC beta antibody for Immunofluorescence (Paraffin-embedded Sections)

Recommended PKC beta Antibody (supplied by: Log in to see )

Antigen
Protein Kinase C, beta (PRKCB) Antibodies
  • PKC-B
  • Prkcb
  • prkcb1
  • zgc:63591
  • PKC-beta
  • PKCB
  • PRKCB1
  • PRKCB2
  • PKC
  • A130082F03Rik
  • PKC-Beta
  • Pkcb
  • Prkcb1
  • Prkcb2
  • protein kinase C, beta b
  • protein kinase C, beta
  • prkcbb
  • PRKCB
  • Prkcb
Epitope
AA 620-673
33
17
17
13
11
10
8
7
3
3
3
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
146
107
106
21
20
15
10
6
5
4
2
2
2
2
2
2
1
1
Host
Rabbit
158
15
7
6
Clonality
Polyclonal
Conjugate
This PKC beta antibody is conjugated to Alexa Fluor 594
12
9
5
5
5
5
2
2
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
166
93
72
24
19
10
7
6
5
4
4
3
3
1
1
Options
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Catalog No. ABIN2805372
$ 405.90
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN2805561 IF (p) Alexa Fluor 594 Rabbit IgG AA 490-520, pThr500 Log in to see Polyclonal
1 ABIN711446 IF (p) IHC (p) WB Rabbit IgG pSer660 Log in to see Polyclonal
1 ABIN5008879 IF (p) Alexa Fluor 680 Rabbit IgG AA 620-673 Log in to see Polyclonal
1 ABIN5008880 IF (p) Alexa Fluor 750 Rabbit IgG AA 620-673 Log in to see Polyclonal
1 ABIN5009175 IF (p) Alexa Fluor 680 Rabbit IgG AA 490-520, pThr500 Log in to see Polyclonal
1 ABIN5009176 IF (p) Alexa Fluor 750 Rabbit IgG AA 490-520, pThr500 Log in to see Polyclonal

Similar anti-PKC beta Antibodies

Application / Reactivity Human Mouse (Murine) Rat (Rattus)
Immunofluorescence (fixed cells) (IF/ICC) 1 Antibodies 1 Antibodies 2 Antibodies
Western Blotting (WB) 127 Antibodies 95 Antibodies 94 Antibodies
Proximity Ligation Assay (PLA) 1 Antibodies
Immunoprecipitation (IP) 7 Antibodies 5 Antibodies 5 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 13 Antibodies 15 Antibodies 12 Antibodies
Immunohistochemistry (IHC) 49 Antibodies 47 Antibodies 38 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 3 Antibodies 4 Antibodies 3 Antibodies

General

Antigen Protein Kinase C, beta (PRKCB) Antibodies
Epitope AA 620-673
(33), (17), (17), (13), (11), (10), (8), (7), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine), Rat (Rattus)
(146), (107), (106), (21), (20), (15), (10), (6), (5), (4), (2), (2), (2), (2), (2), (2), (1), (1)
Host Rabbit
(158), (15), (7), (6)
Clonality
Polyclonal
Conjugate This PKC beta antibody is conjugated to Alexa Fluor 594
(12), (9), (5), (5), (5), (5), (2), (2), (1)
Application Immunofluorescence (Paraffin-embedded Sections) (IF (p))
(166), (93), (72), (24), (19), (10), (7), (6), (5), (4), (4), (3), (3), (1), (1)
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Product Details anti-PKC beta Antibody

Target Details PKC beta Application Details Handling Images
Specificity This antibody will recognize isoform Beta-II of Protein kinase C beta
Purification Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from human PKC beta 2
Isotype IgG

Target Details PKC beta

Product Details anti-PKC beta Antibody Application Details Handling Images back to top
Antigen
Alternative Name PKC beta (PRKCB Antibody Abstract)
Background

Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity. Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A. In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. May participate in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4.

Subcellular location: Cytoplasm, Nucleus, Cell membrane


Synonyms: PKCB, PRKCB1, PRKCB2, PKC-beta, Protein kinase C beta type, PKC-B, PRKCB
Gene ID 5579
UniProt P05771
Pathways WNT Signaling, Thyroid Hormone Synthesis, Nuclear Hormone Receptor Binding, Chromatin Binding, Myometrial Relaxation and Contraction

Application Details

Product Details anti-PKC beta Antibody Target Details PKC beta Handling Images back to top
Application Notes IF(IHC-P)(1:50-200)
Restrictions For Research Use only

Handling

Product Details anti-PKC beta Antibody Target Details PKC beta Application Details Images back to top
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at 4°C
Expiry Date 12 months