Browse our PKC beta Proteins (PRKCB)

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Protein Kinase C, beta Proteins (PRKCB)
On are 19 Protein Kinase C, beta (PRKCB) Proteins from 8 different suppliers available. Additionally we are shipping PKC beta Antibodies (188) and PKC beta Kits (33) and many more products for this protein. A total of 254 PKC beta products are currently listed.
A130082F03Rik, PKC, PKC-B, PKC-Beta, Pkcb, Prkcb, Prkcb1, Prkcb2, zgc:63591
list all proteins Gene Name GeneID UniProt
PRKCB 5579 P05771
PRKCB 18751 P68404
PRKCB 25023 P68403

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PKC beta Proteins (PRKCB) by Origin

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Human Protein Kinase C, beta (PRKCB) interaction partners

  1. our findings identify PRKCB gene as a novel candidate gene for familial Meniere's Disease (MD )and its expression gradient in supporting cells of the organ of Corti deserves attention, given the role of supporting cells in K(+ )recycling within the endolymph, and its apical turn location may explain the onset of hearing loss at low frequencies in MD

  2. Activation of the Pro-Oxidant PKCbetaII-p66Shc (show SHC1 Proteins) Signaling Pathway Contributes to Pericyte Dysfunction in Skeletal Muscles of Patients With Diabetes With Critical Limb Ischemia

  3. Taken together, these data argue for a complex mechanism of PKC-beta-dependent regulation of SH (show POLD3 Proteins)CA (p66) activation invol (show SIGLEC1 Proteins)ving Ser(139) and a motif surroun (show SIGLEC1 Proteins)ding Ser(213).

  4. The study aimed to identify a small set of genetic signatures that may reliably predict the individuals with a high genetic propensity to heroin addiction. A set of 4 genes (JUN (show JUN Proteins), CEBPB (show CEBPB Proteins), PRKCB, ENO2 (show ENO2 Proteins), or CEBPG (show CEBPG Proteins)) could predict the diagnosis of heroin addiction with the accuracy rate around 85% in our dataset.

  5. Our results provide compelling evidence that glucose-induced PKCalpha (show PKCa Proteins)/PKCbeta-mediated inhibition of Kv current in vascular smooth muscle causes an enhanced constrictor response. Inhibition of Kv current causes a significant depolarization of vascular myocytes leading to marked vasoconstriction

  6. Data suggest that targeted manipulation of protein kinase C isoforms PKCalpha (show PKCa Proteins), PKCbeta, and PKCeta might be beneficial in certain proteinuric kidney diseases with altered transient receptor potential cation channel subfamily C member 6 (show TRPC6 Proteins) protein (TRPC6 (show TRPC6 Proteins)) functions.

  7. Bone marrow stroma-induced resistance of chronic lymphocytic leukemia cells to arsenic trioxide involves Mcl-1 upregulation and is overcome by inhibiting the PI3Kdelta or PKCbeta signaling pathways.

  8. PPAR-delta (show PPARD Proteins) and NKIRAS1 (show NKIRAS1 Proteins) are downstream mediators in the PRKCB pathway in human umbilical vein endothelial cells.

  9. Lower hydrogen sulfide (show SQRDL Proteins) is associated with cardiovascular mortality, which involves PKCBII/Akt (show AKT1 Proteins) pathway in chronic hemodialysis patients.

  10. Study found a significant decrease of PRCKB1 mRNA expression in subsyndromal symptomatic depression, suggesting PRKCB1 might be a candidate gene and biomarker

Cow (Bovine) Protein Kinase C, beta (PRKCB) interaction partners

  1. The study identified the serine phosphorylation (p-Ser) sites induced by (show IRS2 Proteins)PKC-Beta activation or AGT, which inhibits insulin-induced p-Tyr sites on IRS2 and its signals in endothelial cells.

Mouse (Murine) Protein Kinase C, beta (PRKCB) interaction partners

  1. Taken together, these data argue for a complex mechanism of PKCbeta-dependent regulation of p66 (show POLD3 Proteins) activation involving Ser (show SIGLEC1 Proteins)(139) and a motif surrounding Ser (show SIGLEC1 Proteins)(213).

  2. Translocation of PKC-betaII from the cytoplasm to membranes is required for phagocytosis of apoptotic cells and is inhibited by soluble beta-glucan

  3. repressor of myogenesis; opposes calcineurin (show PPP3CA Proteins) function

  4. at the functionally mature calyx of Held synapse the Ca(2+)-dependent protein kinase C isoforms alpha and beta are necessary for post-tetanic potentiation, a form of plasticity thought to underlie short-term memory

  5. a new mechanism by which PKC-beta activation promotes EC dysfunction caused by the de-regulation of the IL-18 (show IL18 Proteins)/IL-18BP (show IL18BP Proteins) pathway, leading to increased VCAM-1 (show VCAM1 Proteins) expression, monocyte/macrophage adhesion, and accelerated atherosclerotic plaque formation in diabetes

  6. These results demonstrate the importance of PKCbetaII in chronic lymphocytic leukemia-like disease progression and suggest a role for PKCalpha (show PKCa Proteins) subversion in creating permissive conditions for leukemogenesis.

  7. PKCbeta2 inhibition protects mice from gut (show GUSB Proteins) ischemia-reperfusion injury by suppressing the adaptor p66(Shc)-mediated oxidative stress and subsequent apoptosis.

  8. PKC-alpha (show PKCa Proteins) and -betaIotaIota are the predominant isoforms in the developing optic pathway, whereas PKC-epsilon (show PRKCE Proteins) is the major form in the chiasmatic neurons.

  9. STAT3 (show STAT3 Proteins) bound to previously undescribed negative regulatory elements within the promoter of PRKCB, which encodes PKCbetaII.

  10. These findings indicate that the identity of the calcium-dependent PKCbeta that mediates PTP controls the mechanism and functional consequences of Posttetanic potentiation.

PKC beta (PRKCB) Protein Profile

Protein Summary

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

Alternative names and synonyms associated with PKC beta (PRKCB)

  • protein kinase C, beta b (prkcbb)
  • protein kinase C, beta (PRKCB)
  • protein kinase C, beta (Prkcb)
  • A130082F03Rik protein
  • PKC protein
  • PKC-B protein
  • PKC-Beta protein
  • Pkcb protein
  • Prkcb protein
  • Prkcb1 protein
  • Prkcb2 protein
  • zgc:63591 protein

Protein level used designations for Protein Kinase C, beta Proteins (PRKCB)

PKC-beta , protein kinase C beta type , protein kinase C, beta 1 , protein kinase C, beta , PKC-B , protein kinase C, beta 1 polypeptide , protein kinase C beta 2 , protein kinase C beta-II , protein kinase C beta I , protein kinase C beta II , protein kinase C beta 1

393953 Danio rerio
100590939 Nomascus leucogenys
5579 Homo sapiens
397183 Sus scrofa
282325 Bos taurus
18751 Mus musculus
25023 Rattus norvegicus
100037719 Oryctolagus cuniculus
489968 Canis lupus familiaris
416567 Gallus gallus
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