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Data suggest that PRKCG (protein kinase C gamma) phosphorylates TA isoforms of p63 (tumor protein p63 (show TP63 Proteins)) at Thr157 to stabilize them and promote cell apoptosis in tumor cells.
PKCgamma,mutated in the neurodegenerative disease spinocerebellar ataxia (show USP14 Proteins) type 14 is a novel amyloidogenic protein.
The rs454006 polymorphism of the PRKCG gene correlated to osteosarcoma susceptibility and might increase the risk of osteosarcoma.
findings provide evidence for both an increased PKCgamma activity in Purkinje cells in vivo and for pathological changes typical for cerebellar disease thus linking increased and dysregulated activity of PKCgamma to development of cerebellar disease
we show that the mutation V138E of the protein kinase C gamma (PKCgamma) C1B domain, which is implicated in spinocerebellar ataxia (show USP14 Proteins) type 14, exhibits a partially unfolded C-terminus
PKCgamma plays a critical role in cancer cells, and simultaneous inhibition of PKCgamma and Hsp90alpha (show HSP90AA2 Proteins) synergistically prevents cell migration and promotes apoptosis in cancer cells.
A novel missense mutation, F643L, which maps to a highly conserved amino acid of the catalytic domain of protein kinase C gamma, extends the phenotype associated with the spinocerebellar ataxia (show USP14 Proteins) type 14 (SCA14) locus.
Spinocerebellar ataxia (show USP14 Proteins) type 14 mutant PKC-gamma upregulates Hsp70 (show HSP70 Proteins). Hsp70 (show HSP70 Proteins) has a role in degrading mutant PKC-gamma.
Exome sequencing of large, 5-generational British kindred finds a novel p.Arg26Gly mutation in the PRKCG gene causing familial spinocerebellar ataxia (show USP14 Proteins) 14.
SCA14, a novel mutation in the PRKCG gene, was found in two families in Norway with autosomal dominant cerebellar ataxia (show USP14 Proteins).
Immunoblotting and RT-PCR results showed that NIHL increased the expression of PKCgamma but decreased that of GABABR1 (show GABBR1 Proteins) and GABABR2 (show GABBR2 Proteins) at both protein and mRNA levels in the CNC
Therefore, we propose that PKCgamma positively modulates dopamine release through beta2PIX phosphorylation.
These findings indicate that the identity of the calcium-dependent PKCgamma that mediates PTP controls the mechanism and functional consequences of Posttetanic potentiation.
This study provided new evidence to support the possibility of the involvement of PKC-gamma in the actions of volatile anesthetics in mice brain.
demonstrate a role for the gamma isotype of protein kinase C (PKCgamma) in food-mediated entrainment of behavior and the molecular clock
transient receptor potential 3 which is also needed for mGluR1 (show GRM1 Proteins)-dependent slow excitatory postsynaptic potentials and motor coordination and associates with PKCgamma
Membrane residence time of PKCalpha (show PKCa Proteins) after depolarization-induced translocation is significantly decreased when it is present with the mutant PKCgamma construct of spinocerebellar ataxia (show USP14 Proteins) type 14.
cPLA(2 (show PLA2G4A Proteins))-dependent AA release is required for VEGF (show VEGFA Proteins)-induced Src (show SRC Proteins)-PLD1-PKCgamma-mediated pathological retinal angiogenesis
the expression of transthyretin and protein kinase Cgamma were increased in the prefrontal cortex but not in the hippocampus of naltrexone-treated mice
a potential link between the increased PKCgamma expression and the age-related hearing loss
Here, substitution studies on peptides correlating to the C1B domain in PKC gamma show that a flexible structure and ability to be phosphorylated on serine 109 are critical for this purpose.
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14).
protein kinase C, gamma
, protein kinase C gamma type-like
, protein kinase C gamma type
, protein kinase C type I (gamma type)