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Nine of the 32 (28.1%) iCCA patients had gene mutations at chromosome 3p, totaling 11 mutations across five genes. Those included five (15.6%) BAP1 (show RNF2 ELISA Kits) mutations, two each (6.3%) of CACNA2D3 (show CACNA2D3 ELISA Kits) and RASSF1 (show RASSF1 ELISA Kits) mutations, and one each (3.1%) of ATG7 (show ATG7 ELISA Kits) and PLCD1 mutations. Six (18.8%) cases had concurrent loss of chromosome 3p and gene mutations.
The PLCdelta1 negatively regulates autophagy, and PLCdelta1 suppression contributes to the tolerance of CRC cells harboring KRAS mutations to nutrient deprivation and anti-cancer drug treatment.
Phospholipase C delta 1 is both a KLF15 (show KLF15 ELISA Kits)-regulated gene and a novel repressor of airway smooth muscle hypertrophy.
High PLC (show HSPG2 ELISA Kits) delta expression is associated with breast cancer.
slow phase of Gi/o-mediated TRPC4 (show TRPC4 ELISA Kits) activation was diminished by inhibiting RhoA (show RHOA ELISA Kits) or enhancing PLCdelta function
Neuropeptide Y (show NPY ELISA Kits) decreased PLCD1 expression in HUVECs.
PLC (show HSPG2 ELISA Kits)-delta1 and TRPV6 (show TRPV6 ELISA Kits) are critical actor of Ca(2 (show CA2 ELISA Kits)+) homeostasis in CF human bronchial epithelial cells.
Ectopic expression of PLCD1 inhibits breast tumor cell proliferation in vivo by inducing apoptosis and suppressed tumor cell migration by regulating cytoskeletal reorganization.
Provide evidence for intramolecular interactions in the PLC (show HSPG2 ELISA Kits)-delta1 PH domain.
Genotyping using microsatellite markers linked the families to the gene PLCD1 on chromosome 3p22.2. Sequence analysis of the gene detected one novel (p.Ser740ArgfsX19) and one previously reported mutation (p.Arg437X).
PLCd1 negatively regulates lipopolysaccharide-induced production of IL-1b (show IL1B ELISA Kits) and Fc gamma receptor (show FCGR1A ELISA Kits)-mediated phagocytosis in macrophages.
Data show that phospholipase C delta1 (PLCD1) transfection can induce the apoptosis of CAPAN-1 and BXPC-3 pancreatic cancer cells, arrest the cell cycle in G0 /G1 phase.
the Ca(2 (show CA2 ELISA Kits)+) dependence of the interaction between PRIP (show NCOA6 ELISA Kits)-C2 and Syt1 (show SYT1 ELISA Kits)-C2A was attributed to Ca(2 (show CA2 ELISA Kits)+) binding with Syt1 (show SYT1 ELISA Kits)-C2A, but not PRIP (show NCOA6 ELISA Kits)-C2, using a series of mutants prepared from both C2 domains.
Expression of PLCdelta1 is increased in ALS mouse spinal cord and in neurons from ALS mice. Genetic ablation of this protein in ALS mice significantly increases survival
Identification, characterization and regulatory properties of a novel PLCD1 isoform in mouse.
Plcd1 and Plcd3 (show PLCd3 ELISA Kits) have synergistic effects on the murine hair follicle in specific regions of the body surface.
Loss of phospholipase Cdelta1 from keratinocytes causes features of interleukin-17 (show IL17A ELISA Kits)-associated inflammatory skin diseases.
Results suggest that phospholipase C delta(1) is required for skin stem cell lineage commitment.
the PLC (show HSPG2 ELISA Kits)-delta1 promoter is under the control of NF-kappaB (show NFKB1 ELISA Kits), which mediates the expression of PLC (show HSPG2 ELISA Kits)-delta due to Abeta42
Nuclear translocation of phospholipase C-delta1 is linked to the cell cycle and nuclear phosphatidylinositol 4,5-bisphosphate
This gene encodes a member of the phospholipase C family. Phospholipase C isozymes play critical roles in intracellular signal transduction by catalyzing the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers diacylglycerol (DAG) and inositol triphosphate (IP3). The encoded protein functions as a tumor suppressor in several types of cancer, and mutations in this gene are a cause of hereditary leukonychia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-1
, phosphoinositide phospholipase C-delta-1
, phospholipase C-III
, PLC-delta 1
, phospholipase C delta 1 Lf
, phospholipase C delta-1
, phospholipase C-delta-1
, Phospholipase C-delta1
, phosphoinositide phospholipase C
, phospholipase C delta 1 long form