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Browse our PLCD1 Proteins (PLCD1)

Full name:
phospholipase C, delta 1 Proteins (PLCD1)
On are 5 phospholipase C, delta 1 (PLCD1) Proteins from 4 different suppliers available. Additionally we are shipping PLCD1 Antibodies (33) and PLCD1 Kits (9) and many more products for this protein. A total of 53 PLCD1 products are currently listed.
AW212592, C79986, NDNC3, PLC-III, Plc1
list all proteins Gene Name GeneID UniProt
PLCD1 5333 P51178
PLCD1 18799 Q8R3B1
PLCD1 24655 P10688

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PLCD1 Proteins (PLCD1) by Origin

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More Proteins for PLCD1 Interaction Partners

Human phospholipase C, delta 1 (PLCD1) interaction partners

  1. slow phase of Gi/o-mediated TRPC4 (show TRPC4 Proteins) activation was diminished by inhibiting RhoA (show RHOA Proteins) or enhancing PLCdelta function

  2. Neuropeptide Y (show NPY Proteins) decreased PLCD1 expression in HUVECs.

  3. PLC (show HSPG2 Proteins)-delta1 and TRPV6 (show TRPV6 Proteins) are critical actor of Ca(2 (show CA2 Proteins)+) homeostasis in CF human bronchial epithelial cells.

  4. Ectopic expression of PLCD1 inhibits breast tumor cell proliferation in vivo by inducing apoptosis and suppressed tumor cell migration by regulating cytoskeletal reorganization.

  5. Provide evidence for intramolecular interactions in the PLC (show HSPG2 Proteins)-delta1 PH domain.

  6. Genotyping using microsatellite markers linked the families to the gene PLCD1 on chromosome 3p22.2. Sequence analysis of the gene detected one novel (p.Ser740ArgfsX19) and one previously reported mutation (p.Arg437X).

  7. A novel mutation in the PLCD1 gene, which leads to an aberrant splicing event, underlies autosomal recessive leuconychia.

  8. PLCD1 acts as a functional tumor suppressor and may serve as a biomarker for possible early detection and prognosis of chronic myeloid leukemia (show BCL11A Proteins).

  9. Increased PLC (show HSPG2 Proteins)-delta1 activity causes enhanced coronary vasomotility such as that seen in patients with coronary spastic angina.

  10. Significantly deregulated pathways in colorectal cancer were identified and repression of PLCD1 and PLCE1 expression, was validated.

Mouse (Murine) phospholipase C, delta 1 (PLCD1) interaction partners

  1. the Ca(2+) dependence of the interaction between PRIP-C2 and Syt1-C2A was attributed to Ca(2+) binding with Syt1-C2A, but not PRIP-C2, using a series of mutants prepared from both C2 domains.

  2. Expression of PLCdelta1 is increased in ALS mouse spinal cord and in neurons from ALS mice. Genetic ablation of this protein in ALS mice significantly increases survival

  3. Identification, characterization and regulatory properties of a novel PLCD1 isoform in mouse.

  4. Plcd1 and Plcd3 (show PLCd3 Proteins) have synergistic effects on the murine hair follicle in specific regions of the body surface.

  5. Loss of phospholipase Cdelta1 from keratinocytes causes features of interleukin-17 (show IL17A Proteins)-associated inflammatory skin diseases.

  6. Results suggest that phospholipase C delta(1) is required for skin stem cell lineage commitment.

  7. the PLC (show HSPG2 Proteins)-delta1 promoter is under the control of NF-kappaB (show NFKB1 Proteins), which mediates the expression of PLC (show HSPG2 Proteins)-delta due to Abeta42

  8. Nuclear translocation of phospholipase C-delta1 is linked to the cell cycle and nuclear phosphatidylinositol 4,5-bisphosphate

  9. Data indicate that receptor-triggered phospholipase C (show PLC Proteins) activity is enhanced by positive feedback from Ca2 (show CA2 Proteins)+ entering the cytoplasm from intracellular stores and via store-operated channels in the plasma membrane.

  10. Taken together, these results indicate that lack of PLC (show HSPG2 Proteins)-delta1 induces skin inflammation and that the epidermal hyperplasia in PLC (show HSPG2 Proteins)-delta1 KO mice is caused by skin inflammation.

PLCD1 Protein Profile

Protein Summary

This gene encodes a member of the phospholipase C family. Phospholipase C isozymes play critical roles in intracellular signal transduction by catalyzing the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers diacylglycerol (DAG) and inositol triphosphate (IP3). The encoded protein functions as a tumor suppressor in several types of cancer, and mutations in this gene are a cause of hereditary leukonychia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Alternative names and synonyms associated with PLCD1

  • 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-1-like (PLCD1)
  • phospholipase C, delta 1 (PLCD1)
  • phospholipase C, delta 1 (Plcd1)
  • AW212592 protein
  • C79986 protein
  • NDNC3 protein
  • PLC-III protein
  • Plc1 protein

Protein level used designations for PLCD1

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 , 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-1 , PLC-delta-1 , phosphoinositide phospholipase C-delta-1 , phospholipase C-III , PLC-delta 1 , phospholipase C delta 1 Lf , phospholipase C delta-1 , phospholipase C-delta-1 , PLC-III , Phospholipase C-delta1 , phosphoinositide phospholipase C , phospholipase C delta 1 long form

790012 Bos taurus
5333 Homo sapiens
485586 Canis lupus familiaris
18799 Mus musculus
24655 Rattus norvegicus
281986 Bos taurus
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