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even in the absence of the potentially redundant Pygo1, Pygo2 (show PYGO2 Proteins) does not require the H3K4me2/3 binding activity to sustain its function during mouse development
In mammals, the Pygo1/Pygo2 (show PYGO2 Proteins) genes are not absolutely required for canonical Wnt (show WNT2 Proteins) signaling in most developing systems, but rather function as quantitative transducers, or modulators, of Wnt (show WNT2 Proteins) signal intensity
These results suggest that the Pygopus1 plant homeodomain (PHD (show PDC Proteins)) dimerization is functionally important for Lgs/Bcl9 (show BCL9 Proteins) recognition as well as for the regulation of the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling pathway.
Data show that human and Drosophila Pygo PHD (show PDC Proteins) fingers associate with their cognate HD1 (show HDAC1 Proteins) domains from BCL9/Legless (show BCL9 Proteins) to bind specifically to the histone H3 (show HIST3H3 Proteins) tail methylated at lysine 4 (H3K4me).
identifed conserved residues within Pygopus that are required for binding to Legless (show BCL9 Proteins) in vitro and for their activity in transcription [pygo1]
Involved in signal transduction through the Wnt pathway (By similarity).
pygopus homolog 1
, pygopus 1
, pygopus-like protein 1