Browse our anti-PYGO2 (PYGO2) Antibodies

Full name:
anti-Pygopus Homolog 2 (Drosophila) Antibodies (PYGO2)
On are 26 Pygopus Homolog 2 (Drosophila) (PYGO2) Antibodies from 10 different suppliers available. Additionally we are shipping PYGO2 Proteins (4) and many more products for this protein. A total of 33 PYGO2 products are currently listed.
1190004M21Rik, mpygo2, RGD1308535
list all antibodies Gene Name GeneID UniProt
PYGO2 68911  
PYGO2 295251  
PYGO2 90780 Q9BRQ0

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Most Popular Reactivities for anti-PYGO2 (PYGO2) Antibodies

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anti-Mouse (Murine) PYGO2 Antibodies:

anti-Rat (Rattus) PYGO2 Antibodies:

anti-Human PYGO2 Antibodies:

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Top referenced anti-PYGO2 Antibodies

  1. Human Polyclonal PYGO2 Primary Antibody for ChIP, ICC - ABIN4348740 : Cantù, Valenta, Hausmann, Vilain, Aguet, Basler: The Pygo2-H3K4me2/3 interaction is dispensable for mouse development and Wnt signaling-dependent transcription. in Development (Cambridge, England) 2013 (PubMed)
    Show all 2 references for 4348740

  2. Cow (Bovine) Polyclonal PYGO2 Primary Antibody for WB - ABIN2784477 : Andrews, Kennedy, Popadiuk, Kao: Oncogenic activation of the human Pygopus2 promoter by E74-like factor-1. in Molecular cancer research : MCR 2008 (PubMed)

More Antibodies against PYGO2 Interaction Partners

Mouse (Murine) Pygopus Homolog 2 (Drosophila) (PYGO2) interaction partners

  1. It analyzed Wnt1 (show WNT1 Antibodies)-cre(+/-)::Pygo2(-/-) mice in which the beta-catenin (show CTNNB1 Antibodies) co-activator gene, Pygopus 2 (Pygo2), is deleted specifically in neural crest cells.

  2. These findings identify Pygo2 as an important regulator of Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) function in skin epithelia and p53 (show TP53 Antibodies) activation as a prominent downstream event of beta-catenin (show CTNNB1 Antibodies)/Pygo2 action in stem cell activation.

  3. these results suggest that Pygo2 acts at a step downstream of mammary stem cell accumulation to facilitate transformation, and that it regulates the tumor initiating capacity and lineage preference of the already transformed mammary cells, in MMTV-Wnt1 (show WNT1 Antibodies) mice.

  4. even in the absence of the potentially redundant Pygo1 (show PYGO1 Antibodies), Pygo2 does not require the H3K4me2/3 binding activity to sustain its function during mouse development

  5. Mouse pygo2 expression was detected in the developing epidermis and hair follicles, which suggests that mpygo2 might mediate the effect of this signaling pathway in mouse skin.

  6. In mammals, the Pygo1 (show PYGO1 Antibodies)/Pygo2 genes are not absolutely required for canonical Wnt (show WNT2 Antibodies) signaling in most developing systems, but rather function as quantitative transducers, or modulators, of Wnt (show WNT2 Antibodies) signal intensity

  7. Pygo2 can function in the Wnt (show WNT2 Antibodies) pathway, but its activity in lens development is Wnt (show WNT2 Antibodies) pathway-independent

  8. ablation of pygo2 expression causes defects in morphogenesis of both ectodermally and endodermally derived tissues, including brain, eyes, hair follicles, and lung

  9. Study finds canonical Wnt (show WNT2 Antibodies) signaling to be predominantly active in the mesenchyme at the time when mPygo2 is required and demonstrate the dependence of Wnt (show WNT2 Antibodies) signal transduction on mPygo2.

  10. Pygo2 is involved in the chromatin remodeling events that lead to nuclear compaction of male germ cells

Human Pygopus Homolog 2 (Drosophila) (PYGO2) interaction partners

  1. We also determined the effect of Pygo2 on the sensitivity of breast tumors resistant to doxorubicin in a mouse model. Finally, RNA samples from 64 paired patient tumors (before and after chemotherapy) highly and significantly overexpressed Pygo2 and/or MDR1 after treatment, thus underlining a pivotal role for the Pygo2-mediated Wnt/b-catenin pathway in the clinical chemoresistance of breast cancer.

  2. Findings are consistent with a model in which acetylation of Pygo2 by CBP/p300 (show CREBBP Antibodies) family members in the active TCF (show HNF4A Antibodies)/beta-catenin (show CTNNB1 Antibodies) complex occurs coincident with histone acetylation and may be required for the recycling of Pygo2 away from the complex subsequent to target gene activation.

  3. The activation of its expression by ERalpha (show ESR1 Antibodies) and/or specificity protein-1 (SP1 (show SP1 Antibodies)) suggests hPYGO2 as a theranostic target for hormone therapy responsive and refractory breast cancer.

  4. Pygo2 functions as a prognostic factor for glioma due to its up-regulation of H3K4me3 and promotion of MLL1/MLL2 (show MLL2 Antibodies) complex recruitment.

  5. this study demonstrated that SNPs in the coding region of Pygo2 might be one of the causative factors in idiopathic oligospermia and azoospermia, resulting in male infertility.

  6. Our findings suggest that Pygopus-2 may be an important predictor of poor outcome in HCC (show FAM126A Antibodies) patients, and could serve as a novel biomarker for HCC (show FAM126A Antibodies).

  7. Pygopus-2 over-expression is associated with hepatic carcinoma.

  8. Pygo2 is a common node downstream of oncogenic Wnt (show WNT2 Antibodies) and Akt (show AKT1 Antibodies) signaling pathways.

  9. We conclude that abnormal Pygo2 protein expression may be a marker for advanced non-small cell lung cancer

  10. PYGO2 is identified as a new molecular marker of invasive tumors in esophageal squamous cell carcinoma.

PYGO2 Antigen Profile

Antigen Summary

Involved in signal transduction through the Wnt pathway.

Alternative names and synonyms associated with PYGO2

  • pygopus 2 (Pygo2) antibody
  • pygopus homolog 2 (Drosophila) (PYGO2) antibody
  • 1190004M21Rik antibody
  • mpygo2 antibody
  • RGD1308535 antibody

Protein level used designations for PYGO2

pygopus homolog 2 , pygopus 2

68911 Mus musculus
295251 Rattus norvegicus
90780 Homo sapiens
490440 Canis lupus familiaris
540401 Bos taurus
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