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anti-Human RHOC Antibodies:
anti-Rat (Rattus) RHOC Antibodies:
anti-Mouse (Murine) RHOC Antibodies:
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Human Polyclonal RHOC Primary Antibody for IF (p), IHC (p) - ABIN687157
He, Wei, Du, Meng, Zheng, Lai, Yao, Zhou, Wang, Luo, Ma, Zhang: Transcription of HOTAIR is regulated by RhoC-MRTF-A-SRF signaling pathway in human breast cancer cells. in Cellular signalling 2017
Cow (Bovine) Polyclonal RHOC Primary Antibody for IHC, WB - ABIN2786344
Sousa, Espreafico: Suppression subtractive hybridization profiles of radial growth phase and metastatic melanoma cell lines reveal novel potential targets. in BMC cancer 2008
Human Monoclonal RHOC Primary Antibody for ELISA, WB - ABIN513475
Han, Li, Hu, Yu, Zheng, Guo, Zheng, Yi, Zhou: Epidermal growth factor stimulates human trophoblast cell migration through Rho A and Rho C activation. in Endocrinology 2010
Human Monoclonal RHOC Primary Antibody for IF, ELISA - ABIN513476
Saito, Ohmasa, Shomori, Dimitriadis, Ohiwa, Shimizu, Tsounapi, Kinoshita, Satoh: Rhos and Rho kinases in the rat prostate: their possible functional roles and distributions. in Molecular and cellular biochemistry 2011
Human Polyclonal RHOC Primary Antibody for ELISA, WB - ABIN559936
Han, Yang, Li, Li, Zheng, Yu, Zhang, Zheng, Yi, Li, Guo, Zhou: RhoB/ROCK mediates oxygen-glucose deprivation-stimulated syncytiotrophoblast microparticle shedding in preeclampsia. in Cell and tissue research 2016
HOTAIR is regulated by the RhoC-MRTF-A-SRF signaling pathway in breast cancer cells.
E2F transcription factor 1 (E2F1 (show E2F1 Antibodies)) downregulated micrRNA miR (show MLXIP Antibodies)-519d directly and miR (show MLXIP Antibodies)-519d downregulated Ras homolog gene family member C (RhoC) directly.
These results reveal a previously unidentified pathway downstream of RHO that regulates the polarity of migrating cells through Golgi reorientation in a FAM65A-, CCM3 (show PDCD10 Antibodies)- and MST3 (show STK24 Antibodies)- and MST4 (show MST4 Antibodies)-dependent manner.
During the process of epithelial-mesenchymal transition in A549 cells induced by TGF-beta1 (show TGFB1 Antibodies), upregulated RhoC protein and RhoC activity were detected, which was associated with the enhanced invasive capability of the cells in vitro.
RhoC downregulation may inhibit the proliferation, drug resistance, invasion and migration of ovarian cancer stem cells.
Downregulation of RHOC inhibited cholangiocellular carcinoma cells invasion and migration partially via inhibition of matrix metalloproteinase 2 (show MMP2 Antibodies), 3 and 9 expression. RHOC also modulated the expression of several epithelial-mesenchymal transition (EMT (show ITK Antibodies))-associated proteins
RT-PCR and Western blot assays demonstrated that miR (show MLXIP Antibodies)-372 transfection reduced the expression of RhoC.
Significant associations between ROCK1 (show ROCK1 Antibodies), ROCK2 (show ROCK2 Antibodies), RhoA (show RHOA Antibodies) and RhoC gene polymorphisms and systemic sclerosis were demonstrated.
study has identified several new proteins like RHOC, DLG5 (show DLG5 Antibodies), UGDH (show UGDH Antibodies), TMOD3 (show TMOD3 Antibodies) in addition to known chemoresistance associated proteins in non-small cell lung carcinoma.
the oncogene (show RAB1A Antibodies) RhoC, a driver of metastatic potential, modulates glutamine (show GFPT1 Antibodies) and N-acetylaspartate metabolism in Inflammatory Breast Cancer cells in vitro, revealing a novel role for RhoC as a regulator of tumor cell metabolism that extends beyond its well known role in cytoskeletal rearrangement.
RhoC co-localizes with Fam65b (show FAM65B Antibodies) in stereocilia and regulates Fam65b (show FAM65B Antibodies) oligomerization what is critical for hair cell function.
Inhibition of ovarian epithelial carcinoma tumorigenesis and progression by miR106b proceeds through the RhoC pathway.
RHOC and RAB38 (show RAB38 Antibodies) are dispensable for osteoclast function.
A p27(kip1 (show CDKN1B Antibodies))-binding protein, p27RF-Rho (show LAMTOR1 Antibodies), promotes cancer metastasis via activation of RhoA (show RHOA Antibodies) and RhoC.
We found that both RhoA and RhoC, but not RhoB, were required for initiation of centrosome duplication, and overactivation of RhoA, as well as RhoC, but not RhoB, promoted centrosome duplication and centrosome amplification.
RhoC has a role in metastasis of lung cancer in mice
loss of RhoC does not affect tumor development but decreases tumor cell motility and metastatic cell survival leading to a drastic inhibition of metastasis
RhoC promotes melanoma progression via separate mechanisms that regulate the PI3K/Akt (show AKT1 Antibodies) pathway and the ROCK signaling pathway.
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified.
ras homolog gene family, member C
, rho-related GTP-binding protein RhoC
, RAS-related homolog 9
, oncogene RHO H9
, rho cDNA clone 9
, rhoC GTPase
, small GTP binding protein RhoC
, aplysia ras-related homolog 9 (RhoC)
, ras homolog 9 (RhoC)
, silica-induced gene 61 protein
, GTP-binding protein
, GTPase cRhoC