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anti-Human SFRP1 Antibodies:
anti-Mouse (Murine) SFRP1 Antibodies:
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Human Polyclonal SFRP1 Primary Antibody for ELISA, WB - ABIN1043877
Garcia-Hoyos, Cantalapiedra, Arroyo, Esteve, Rodríguez, Riveiro, Trujillo, Ramos, Bovolenta, Ayuso: Evaluation of SFRP1 as a candidate for human retinal dystrophies. in Molecular vision 2004
Show all 2 Pubmed References
Human Polyclonal SFRP1 Primary Antibody for ELISA, IHC - ABIN4353134
Gumz, Zou, Kreinest, Childs, Belmonte, LeGrand, Wu, Luxon, Sinha, Parker, Sun, Ahlquist, Wood, Copland: Secreted frizzled-related protein 1 loss contributes to tumor phenotype of clear cell renal cell carcinoma. in Clinical cancer research : an official journal of the American Association for Cancer Research 2007
Human Polyclonal SFRP1 Primary Antibody for IF (p), IHC (p) - ABIN674694
Wang, Xie, Xie, Wan, Ma, Qi, Yang: MiR-27a regulates Wnt/beta-catenin signaling through targeting SFRP1 in glioma. in Neuroreport 2015
Cow (Bovine) Polyclonal SFRP1 Primary Antibody for WB - ABIN2792235
Caldwell, Jones, Taniere, Warrack, Soon, Matthews, Morton: The Wnt antagonist sFRP1 is downregulated in premalignant large bowel adenomas. in British journal of cancer 2006
Show all 2 Pubmed References
H2O2-induced SFRP1 gene demethylation contributes to H2O2-induced apoptosis in human U251 glioma cells.
Data suggest that microRNA miR (show MLXIP Antibodies)-27a may activate the Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling pathway by negatively regulating SFRP1 to promote the proliferation, migration and invasion of breast cancer (BC) cells.
Data indicate that microRNA miR (show MLXIP Antibodies)-744 activated Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) pathway by targeting multiple negative regulators of Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling, including SFRP1, GSK3beta (show GSK3b Antibodies), TLE3 and NKD1 (show NKD1 Antibodies), and that NKD1 (show NKD1 Antibodies) is a major functional target of miR (show MLXIP Antibodies)-744.
Our results indicate that DKK1 (show DKK1 Antibodies) and SFRP1 may be potentially useful biomarkers for evaluating the beneficial effects of long-term exercise on physical fitness and metabolism as well as the prognosis of patients with cancer.
MiR-1 (show FSD1 Antibodies)-3p suppresses the proliferation, invasion and migration of bladder cancer cells by up-regulating SFRP1 expression.
SFRP1 mRNA expression was reduced by both resistant starch and polydextrose. Resistant starch and polydextrose did not affect SFRP1 methylation or alter the expression of 10 microRNAs predicted to target SFRP1.
Taken together, our results suggest that canonical Wnt signaling and its antagonist, sFRP1, regulate proliferation of human CSCs. Furthermore, excess sFRP1 in elderly patients causes CSC aging.
Genetic variants in the 3' untranslated region of sFRP1 gene is associated with risk of gastric cancer.
This study suggested mechanistic relationship between miR (show MLXIP Antibodies)-940 and Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) in the development and progression of pancreatic carcinoma through regulation of GSK3beta (show GSK3b Antibodies) and sFRP1.
In prostate cancer decreased SFRP1 expression can be due to occupancy of H3K27me3 or to promoter DNA hypermethylation.
OVOL1 (show OVOL1 Antibodies)-regulated Fst (show FST Antibodies) and SFRP1 affect hair inductive potency of neonatal dermal cells.
Down stream actions of estrogen-mediated signaling, including cellular proliferation and progesterone receptor (show PGR Antibodies) transcription, are elevated in estradiol treated explant cultures derived from Sfrp1(-/-) mice.
Study suggests that the induction of the WNT (show WNT2 Antibodies) pathway is a potentially crucial pathway in the development of cardiomyopathy with aging with sFRP-1 being a critical factor in maintaining normal cardiovascular structure and function during this process.
the expression of Sfrp1 is a critical factor required for maintaining appropriate cellular signaling in response to the onset of obesity
findings suggest that SFRP1 expression in the adult maintains progenitor cells within their undifferentiated state and suggests that manipulation of this pathway is a potential target to augment the lung repair process during disease
Sfrp1 is required for inhibition of renal damage through the non-canonical Wnt (show WNT2 Antibodies)/PCP (show BMP1 Antibodies) pathway in a mouse model of obstructive nephropathy
SFRP1 deficiency in mice results in the development of diet-induced obesity aggravated by inflammation and breast cancer.
Sfrp1(-/-) mice have less DNA fragmentation, whilst caspase-3 (show CASP3 Antibodies) expression is decreased, and that p53 (show TP53 Antibodies) expression is generally diminished.
secreted FRP1 either inhibits or enhances signaling in the Wnt3a (show WNT3A Antibodies)/beta-catenin (show CTNNB1 Antibodies) pathway
Sfrp1 and Sfrp2 (show SFRP2 Antibodies) appear to have a positive regulatory function because Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling in lens epithelial cells was reduced in Sfrp1 and Sfrp2 (show SFRP2 Antibodies) DKO mice
Results show the expression level of SFRP1 significantly higher in the embryonic skeletal muscle and diminishes after, whereas miR-206/1 show the inverse. Also, SFRP1 gene is regulated by miR-1/206 and potentially affects skeletal muscle development.
This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling\; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina.
secreted frizzled-related protein 1
, Secreted frizzled-related protein 1
, secreted apoptosis-related protein 2
, secreted frizzled related protein 1
, frizzled in aorta protein
, frzA protein
, secreted frizzled-related sequence protein 1