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anti-Human SFRP1 Antibodies:
anti-Mouse (Murine) SFRP1 Antibodies:
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Cow (Bovine) Polyclonal SFRP1 Primary Antibody for EIA, IF - ABIN401251
Garcia-Hoyos, Cantalapiedra, Arroyo, Esteve, Rodríguez, Riveiro, Trujillo, Ramos, Bovolenta, Ayuso: Evaluation of SFRP1 as a candidate for human retinal dystrophies. in Molecular vision 2004
Show all 8 references for ABIN401251
Chicken Polyclonal SFRP1 Primary Antibody for WB - ABIN2792235
Caldwell, Jones, Taniere, Warrack, Soon, Matthews, Morton: The Wnt antagonist sFRP1 is downregulated in premalignant large bowel adenomas. in British journal of cancer 2006
Show all 2 references for ABIN2792235
Human Polyclonal SFRP1 Primary Antibody for ELISA, WB - ABIN1043877
Han, Amar: Secreted frizzled-related protein 1 (SFRP1) protects fibroblasts from ceramide-induced apoptosis. in The Journal of biological chemistry 2004
Show all 2 references for ABIN1043877
Human Polyclonal SFRP1 Primary Antibody for EIA, FACS - ABIN954759
Huang, Yu, Deng, Sheng, Peng, Qin, Du: SFRP4 was overexpressed in colorectal carcinoma. in Journal of cancer research and clinical oncology 2010
Show all 2 references for ABIN954759
Human Polyclonal SFRP1 Primary Antibody for IF (p), IHC (p) - ABIN674694
Wang, Xie, Xie, Wan, Ma, Qi, Yang: MiR-27a regulates Wnt/beta-catenin signaling through targeting SFRP1 in glioma. in Neuroreport 2015
SFRP1 downregulation may result from epigenetic silencing and is associated with worse survival in nasopharyngeal carcinoma
in gliomas there was correlation of SFRP1 methylation with tumor grade and patients' survival
Hepatocellular carcinoma patients with high SFRP1 expression in tumor tissue had a significantly better overall survival rate.
Reduced SFRP1 expression is associated with acute myeloid leukemia (show BCL11A Antibodies).
Hypermethylation of the selected markers (MAL (show MAL Antibodies), PRIMA1, PTGDR (show PTGDR Antibodies) and SFRP1) can result in reduced gene expression and may contribute to the formation of colorectal cancer.
SFRP1 is a direct target of MiR (show MLXIP Antibodies)-27a in the regulation of glioma invasion and cell migration.
In human mammary epithelial cells with either SFRP1 knocked down (TERT-siSFRP1) and rescued SFRP1 expression ( (show PGR Antibodies)MCF7-SFRP1), estrogen signaling is augmented.
The increased placental expression of sFRP1 seen in smokers impairs fetal growth by inhibiting WNT (show WNT2 Antibodies) signaling and trophoblast proliferation.
miR (show MLXIP Antibodies)-27a induced gene silencing contributes to bone metabolism in hFOB cells in vitro, which is partly affected by the post-transcriptional regulation of sFRP1, during osteoblast proliferation, apoptosis and differentiation.
While SFRP1 re-expression generally mediated distinct patterns of transcriptionally induced or repressed genes in BT20 and SKBR3 cells, BDNF (show BDNF Antibodies) was a SFRP1-induced gene in both cell lines.
OVOL1 (show OVOL1 Antibodies)-regulated Fst (show FST Antibodies) and SFRP1 affect hair inductive potency of neonatal dermal cells.
Down stream actions of estrogen-mediated signaling, including cellular proliferation and progesterone receptor (show PGR Antibodies) transcription, are elevated in estradiol treated explant cultures derived from Sfrp1(-/-) mice.
Study suggests that the induction of the WNT (show WNT2 Antibodies) pathway is a potentially crucial pathway in the development of cardiomyopathy with aging with sFRP-1 being a critical factor in maintaining normal cardiovascular structure and function during this process.
the expression of Sfrp1 is a critical factor required for maintaining appropriate cellular signaling in response to the onset of obesity
findings suggest that SFRP1 expression in the adult maintains progenitor cells within their undifferentiated state and suggests that manipulation of this pathway is a potential target to augment the lung repair process during disease
Sfrp1 is required for inhibition of renal damage through the non-canonical Wnt (show WNT2 Antibodies)/PCP (show BMP1 Antibodies) pathway in a mouse model of obstructive nephropathy
SFRP1 deficiency in mice results in the development of diet-induced obesity aggravated by inflammation and breast cancer.
Sfrp1(-/-) mice have less DNA fragmentation, whilst caspase-3 (show CASP3 Antibodies) expression is decreased, and that p53 (show TP53 Antibodies) expression is generally diminished.
secreted FRP1 either inhibits or enhances signaling in the Wnt3a (show WNT3A Antibodies)/beta-catenin (show CTNNB1 Antibodies) pathway
Sfrp1 and Sfrp2 (show SFRP2 Antibodies) appear to have a positive regulatory function because Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling in lens epithelial cells was reduced in Sfrp1 and Sfrp2 (show SFRP2 Antibodies) DKO mice
Results show the expression level of SFRP1 significantly higher in the embryonic skeletal muscle and diminishes after, whereas miR-206/1 show the inverse. Also, SFRP1 gene is regulated by miR-1/206 and potentially affects skeletal muscle development.
This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling\; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina.
secreted frizzled-related protein 1
, Secreted frizzled-related protein 1
, secreted apoptosis-related protein 2
, secreted frizzled related protein 1
, frizzled in aorta protein
, frzA protein
, secreted frizzled-related sequence protein 1