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Browse our SFRP2 Proteins (SFRP2)

Full name:
Secreted Frizzled-Related Protein 2 Proteins (SFRP2)
On www.antibodies-online.com are 10 Secreted Frizzled-Related Protein 2 (SFRP2) Proteins from 7 different suppliers available. Additionally we are shipping SFRP2 Antibodies (62) and SFRP2 Kits (40) and many more products for this protein. A total of 123 SFRP2 products are currently listed.
Synonyms:
AI851596, FRP-2, hm:zeh0225, SARP1, SDF-5, Sdf5, SFRP-2, sfrp2, zeh0225, zgc:153618
list all proteins Gene Name GeneID UniProt
SFRP2 6423 Q96HF1
SFRP2 20319 P97299
SFRP2 310552  

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SFRP2 Proteins (SFRP2) by Origin

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Top referenced SFRP2 Proteins

  1. Mouse (Murine) SFRP2 Protein expressed in Human Cells - ABIN2007179 : Veeck, Niederacher, An, Klopocki, Wiesmann, Betz, Galm, Camara, Dürst, Kristiansen, Huszka, Knüchel, Dahl: Aberrant methylation of the Wnt antagonist SFRP1 in breast cancer is associated with unfavourable prognosis. in Oncogene 2006 (PubMed)

More Proteins for SFRP2 Interaction Partners

Xenopus laevis Secreted Frizzled-Related Protein 2 (SFRP2) interaction partners

  1. cysteine-rich domain of sFRP2 is sufficient for Ror2 activation, and related sFRPs can substitute for this function. Notably, direct interaction of the two receptors via their cysteine-rich domains also promotes Ror2-mediated papc expression but inhibits Fz7 signaling.

Human Secreted Frizzled-Related Protein 2 (SFRP2) interaction partners

  1. down-regulated in ICU-acquired weakness and mice with inflammation-induced muscle atrophy; possibly establishes a positive feedback loop enhancing TGF-beta1 (show TGFB1 Proteins)-mediated atrophic effects in inflammation-induced atrophy

  2. epigenetic silencing of Wnt (show WNT2 Proteins) antagonists was associated with gastric carcinogenesis, and concurrent hypermethylation of SFRP2 and DKK2 (show DKK2 Proteins) could be a potential marker for a prognosis of poor overall survival.

  3. SFRP2 enhances the adipogenic and neurogenic differentiation (show NEUROD1 Proteins) potentials of stem cells from apical papilla by up-regulating SOX2 (show SOX2 Proteins) and OCT4 (show POU5F1 Proteins).

  4. SFRP2 is not only an agonist of Wnt (show WNT2 Proteins) pathway, but also a cancer promoting protein for lung cancer.

  5. DKK1 (dickkopf-1 (show DKK1 Proteins)) and SFRP2 (secreted frizzled-related protein 2) were the targets of miR (show MLXIP Proteins)-522 in hepatocellular carcinoma

  6. the demethylation of SFRP2 gene appeared to inhibit nuclear retention of a key Wnt (show WNT2 Proteins) signaling factor, b-catenin, in osteosarcoma (OS) cell lines. Together, these data suggest that SFRP2 may function as an OS invasion suppressor by interfering with Wnt (show WNT2 Proteins) signaling, and the methylation of SFRP2 gene may promote pathogenesis of OS

  7. SFRP2 hypermethylation is associated with colorectal cancer.

  8. Silencing KDM2A (show KDM2A Proteins), a histone demethylase (show MBD2 Proteins) and BCL6 co-repressor (show BCOR Proteins), de-repressed SFRP2 transcription by increasing histone H3K4 and H3K36 methylation at the SFRP2 promoter.

  9. SFRP2 protein plays a role in the ultraviolet rays induced hyperpigmentary disorders.

  10. age-related increases in sFRP2 augment both angiogenesis and metastasis of melanoma cells

Mouse (Murine) Secreted Frizzled-Related Protein 2 (SFRP2) interaction partners

  1. these data reveal a novel mechanism that the Bmp4 (show BMP4 Proteins)-Msx1 (show MSX1 Proteins) pathway and Osr2 control tooth organogenesis through antagonistic regulation of expression of secreted Wnt (show WNT2 Proteins) antagonists.

  2. The functional versatility and signaling complexity of sFRP2 in cardiac fibrosis may be better defined.

  3. A novel role of Sfrp2 and Wnt6 in regulating the dynamic process of CPC proliferation and differentiation.

  4. SREBP-1 (show SREBF1 Proteins) acts as a positive regulator of Sfrp2 transcription in chondrogenic cells.

  5. In cardiac fibroblasts, sFRP2 promotes cardiac fibrocalcification through activation of TNAP (show ALPL Proteins).

  6. SFRP2 is suggested to modulate the influx from extracellular calcium in the B cell receptor signaling pathway.

  7. sFRP2 controls apoptosis, cell fate and the Wnt (show WNT2 Proteins) pathway in intestinal epithelium.

  8. Bone morphogenetic protein 2 (BMP2 (show BMP2 Proteins)), BMP4 (show BMP4 Proteins), and secreted frizzled related protein 2 are principal effectors of quiescence of adult mammalian retinal stem cells.

  9. Sfrp1 (show SFRP1 Proteins) and Sfrp2 appear to have a positive regulatory function because Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling in lens epithelial cells was reduced in Sfrp1 (show SFRP1 Proteins) and Sfrp2 DKO mice

  10. Data show that PPARgamma (show PPARG Proteins) protects against vascular calcification by inducing the expression of secreted frizzled-related protein-2, which functions as a Wnt5a (show WNT5A Proteins) antagonist.

Zebrafish Secreted Frizzled-Related Protein 2 (SFRP2) interaction partners

  1. cysteine-rich domain of sFRP2 is sufficient for Ror2 activation, and related sFRPs can substitute for this function. Notably, direct interaction of the two receptors via their cysteine-rich domains also promotes Ror2-mediated papc expression but inhibits Fz7 signaling.

SFRP2 Protein Profile

Protein Summary

This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer.

Alternative names and synonyms associated with SFRP2

  • secreted frizzled-related protein 2 (sfrp2)
  • secreted frizzled-related protein 2 (SFRP2)
  • secreted frizzled-related protein (sfrp2)
  • sfrp2 (LOAG_01461)
  • secreted frizzled-related protein 2 (Sfrp2)
  • AI851596 protein
  • FRP-2 protein
  • hm:zeh0225 protein
  • SARP1 protein
  • SDF-5 protein
  • Sdf5 protein
  • SFRP-2 protein
  • sfrp2 protein
  • zeh0225 protein
  • zgc:153618 protein

Protein level used designations for SFRP2

secreted frizzled-related protein 2 , secreted frizzled-related sequence protein 2 , secreted frizzled-related protein , sfrp2 , SARP-1 , sFRP-2 , secreted apoptosis related protein 1 , secreted apoptosis-related protein 1 , secreted frizzled related protein 2 , secreted frizzled-related sequence protein 5 , stromal cell derived factor 5 , secreted frizzled-related protein-2

GENE ID SPECIES
394659 Xenopus (Silurana) tropicalis
742398 Pan troglodytes
100302355 Ovis aries
380355 Xenopus laevis
778984 Ciona intestinalis
9938836 Loa loa
6423 Homo sapiens
475471 Canis lupus familiaris
20319 Mus musculus
310552 Rattus norvegicus
510821 Bos taurus
100009572 Oryctolagus cuniculus
566878 Danio rerio
395546 Gallus gallus
100516027 Sus scrofa
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