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cysteine-rich domain of sFRP2 is sufficient for Ror2 activation, and related sFRPs can substitute for this function. Notably, direct interaction of the two receptors via their cysteine-rich domains also promotes Ror2-mediated papc expression but inhibits Fz7 signaling.
TET1 (show TET1 Proteins) potently inhibited canonical Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling by demethylating and upregulating two upstream antagonists of this pathway, SFRP2 and DKK1 (show DKK1 Proteins), which was associated with inhibition of EMT (show ITK Proteins) and cancer cell metastasis.
SFRP2 could bind to locally present Wnt (show WNT2 Proteins) ligands and alter the balance of intracellular Wnt (show WNT2 Proteins) signaling to antagonize the canonical Wnt (show WNT2 Proteins) pathway in stem cells from the apical papilla.
SFRP2 induction is remarkable in tumor stroma, with transcription mainly modulated by the nuclear factor-kappaB (NF-kappaB (show NFKB1 Proteins)) complex, a property shared by several effectors of the DNA damage secretory program.
down-regulated in ICU-acquired weakness and mice with inflammation-induced muscle atrophy; possibly establishes a positive feedback loop enhancing TGF-beta1 (show TGFB1 Proteins)-mediated atrophic effects in inflammation-induced atrophy
epigenetic silencing of Wnt (show WNT2 Proteins) antagonists was associated with gastric carcinogenesis, and concurrent hypermethylation of SFRP2 and DKK2 (show DKK2 Proteins) could be a potential marker for a prognosis of poor overall survival.
SFRP2 enhances the adipogenic and neurogenic differentiation (show NEUROD1 Proteins) potentials of stem cells from apical papilla by up-regulating SOX2 (show SOX2 Proteins) and OCT4 (show POU5F1 Proteins).
SFRP2 is not only an agonist of Wnt (show WNT2 Proteins) pathway, but also a cancer promoting protein for lung cancer.
DKK1 (dickkopf-1 (show DKK1 Proteins)) and SFRP2 (secreted frizzled-related protein 2) were the targets of miR (show MLXIP Proteins)-522 in hepatocellular carcinoma
the demethylation of SFRP2 gene appeared to inhibit nuclear retention of a key Wnt (show WNT2 Proteins) signaling factor, b-catenin, in osteosarcoma (OS) cell lines. Together, these data suggest that SFRP2 may function as an OS invasion suppressor by interfering with Wnt (show WNT2 Proteins) signaling, and the methylation of SFRP2 gene may promote pathogenesis of OS
SFRP2 hypermethylation is associated with colorectal cancer.
Sfrp2 expression in the niche is required to maintain the hematopoietic stem cell pool.
these data reveal a novel mechanism that the Bmp4 (show BMP4 Proteins)-Msx1 (show MSX1 Proteins) pathway and Osr2 control tooth organogenesis through antagonistic regulation of expression of secreted Wnt (show WNT2 Proteins) antagonists.
The functional versatility and signaling complexity of sFRP2 in cardiac fibrosis may be better defined.
A novel role of Sfrp2 and Wnt6 in regulating the dynamic process of CPC proliferation and differentiation.
SREBP-1 (show SREBF1 Proteins) acts as a positive regulator of Sfrp2 transcription in chondrogenic cells.
In cardiac fibroblasts, sFRP2 promotes cardiac fibrocalcification through activation of TNAP (show ALPL Proteins).
SFRP2 is suggested to modulate the influx from extracellular calcium in the B cell receptor signaling pathway.
sFRP2 controls apoptosis, cell fate and the Wnt (show WNT2 Proteins) pathway in intestinal epithelium.
Bone morphogenetic protein 2 (BMP2 (show BMP2 Proteins)), BMP4 (show BMP4 Proteins), and secreted frizzled related protein 2 are principal effectors of quiescence of adult mammalian retinal stem cells.
Sfrp1 (show SFRP1 Proteins) and Sfrp2 appear to have a positive regulatory function because Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling in lens epithelial cells was reduced in Sfrp1 (show SFRP1 Proteins) and Sfrp2 DKO mice
This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer.
secreted frizzled-related protein 2
, secreted frizzled-related sequence protein 2
, secreted frizzled-related protein
, secreted apoptosis related protein 1
, secreted apoptosis-related protein 1
, secreted frizzled related protein 2
, secreted frizzled-related sequence protein 5
, stromal cell derived factor 5
, secreted frizzled-related protein-2