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High expression of TCF7 is associated with osteosarcoma.
Findings indicate that breast cancer cells with a hyperactive AF1q (show MLLT11 ELISA Kits)/TCF7/CD44 (show CD44 ELISA Kits) regulatory axis in the primary sites may represent "metastatic founder cells" which have invasive properties.
TCF7 plays critical roles in lung diseases [review]
Tcf7 levels are lower in islets taken from patients with type 2 diabetes. Knockdown of TCF7 in islets impairs the cytoprotective respo (show GIP ELISA Kits)nsiveness to GIP and enhances the magnitude of apoptotic injury.
Capsaicin-induced apoptosis in pancreatic cancer cells was associated with inhibition of beta-catenin (show CTNNB1 ELISA Kits) signaling due to the dissociation of beta-catenin (show CTNNB1 ELISA Kits)/TCF-1 (show HNF1A ELISA Kits) complex and the process was orchestrated by STAT-3 (show STAT3 ELISA Kits).
we show that TCF7 is a direct target of miR (show MLXIP ELISA Kits)-34a in prostate cancer that has metastasized to the bone
induction of expression activates the Wnt (show WNT2 ELISA Kits) signaling pathway, leading to priming of liver cancer stem cells self-renewal and tumor propagation
RUNX2 (show RUNX2 ELISA Kits) signaling pathways with their partners TCF7 and FGFR1 (show FGFR1 ELISA Kits)/2 may not be involved in CCD (show RUNX2 ELISA Kits) pathogenesis
Results suggest ivermectin as therapeutic WNT protein-TCF (show HNF4A ELISA Kits) transcription factor pathway response blocker to treat WNT (show WNT2 ELISA Kits)-TCF (show HNF4A ELISA Kits)-dependent diseases including multiple cancers.
miRNAs inhibited the expression of the luciferase reporter constructs containing 3'UTRs of these genes and downregulated protein expression of TERT (show TERT ELISA Kits) and the TCF7 transcription factor, which mediates the canonical Wnt (show WNT2 ELISA Kits) pathway.
Tcf7 levels are lower in islets taken from diabetic mice. Knockdown of TCF7 in islets impairs the cytoprotective responsiveness to GIP (show GIP ELISA Kits) and enhances the magnitude of apoptotic injury.
TCF-1-deficient CD4+ CD8+ double positive thymocytes fail to undergo TCR alpha Valpha14-Jalpha18 rearrangement and produce significantly fewer Natural killer T cells.
The data suggest that miR (show MLXIP ELISA Kits)-24 participates in osteogenic differentiation by targeting and regulating Tcf-1 (show HNF1A ELISA Kits) expression in osteoblastic cells.
this study proposes a regulatory role for TCF7 in limiting access to the Treg lineage
Our results support a critical role for miR (show MLXIP ELISA Kits)-22-3p and its target, Tcf7, in the pathogenesis of diabetes by upregulating gluconeogenesis.
TCF-1 (show HNF1A ELISA Kits) was essential for both the initiation of T(FH) differentiation and the effector function of differentiated T(FH) cells during acute viral infection. TCF-1 (show HNF1A ELISA Kits) promoted Bcl-6 (show BCL6 ELISA Kits) expression but repressed Blimp1 (show PRDM1 ELISA Kits) expression.
Chromatin immunoprecipitation sequencing revealed the transcription factor Tcf7 and the chemokine receptor (show CCR1 ELISA Kits) Ccr7 (show CCR7 ELISA Kits) as Foxo1 (show FOXO1 ELISA Kits)-bound target genes, which have critical functions in central-memory T cell differentiation and trafficking.
Our data support that the loss of Tcf7 diminishes hematopoietic stem cell function.
TCF-1 (show HNF1A ELISA Kits) mediates repression of Notch (show NOTCH1 ELISA Kits) pathway in T lineage-committed early thymocytes.
These results are reminiscent of the critical roles of TCF-1 (show HNF1A ELISA Kits) in early T cell development.
The protein encoded by this gene is a transcriptional activator that plays an important role in lymphocyte differentiation. This gene is expressed predominantly in T-cells. The encoded protein can bind an enhancer element and activate the CD3E gene, and it also may repress the CTNNB1 and TCF7L2 genes through a feedback mechanism. Several transcript variants encoding different isoforms have been found for this gene.
T-cell-specific transcription factor 1
, transcription factor 7
, transcription factor 7, T-cell specific
, T cell factor-1
, T-cell factor 1