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Tcf7l1 defines the border between the neural crest and the prospective forebrain via restriction of the Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signaling gradient.
report the identification of two independent missense variants in human TCF7L1, p.R92P and p.R400Q, in a cohort of patients with forebrain and/or pituitary defects
The authors find that downstream of glycogen synthase kinase 3 (show GSK3a ELISA Kits) inhibition, elevated cMyc (show MYC ELISA Kits) and beta-catenin (show CTNNB1 ELISA Kits) act in parallel to reduce transcription and DNA binding, respectively, of the transcriptional repressor Tcf7l1.
Sox4 and Tcf7l1 form a functional axis that promotes the progression of BCR-ABL (show ABL1 ELISA Kits)-positive acute lymphoblastic leukemia.
The role of Tcf7l1 in mammals is to inhibit the gene regulatory network to ensure the coordination of lineage specification with the dynamic cellular events occurring during gastrulation.
results establish TCF7L1 as a transcriptional hub coordinating cell-cell contact with the transcriptional repression required for adipogenic competency
Tcf3-/- embryos proceed through gastrulation to form mesoderm, but they develop expanded and often duplicated axial mesoderm structures, including nodes and notochords.
E2A (show TCF3 ELISA Kits)-PBX1 (show PBX1 ELISA Kits) interacts directly with the KIX domain of CBP/p300 (show CREBBP ELISA Kits) in the induction of proliferation in primary hematopoietic cells
Tcf3-mediated control of Nanog levels allows stem cells to balance the creation of lineage-committed and undifferentiated cells
These data suggest that in the absence of Wnt (show WNT2 ELISA Kits) signals, Tcf3 may function in skin SCs (show TWIST1 ELISA Kits) to maintain an undifferentiated state and, through Wnt (show WNT2 ELISA Kits) signaling, directs these cells along the hair lineage.
report the identification of two independent missense variants in human TCF7L1 (show TCF3 ELISA Kits), p.R92P and p.R400Q, in a cohort of patients with forebrain and/or pituitary defects
Data indicate that median methylation levels of BCAN (show BCAN ELISA Kits), HOXD1 (show HOXD1 ELISA Kits), KCTD8 (show KCTD8 ELISA Kits), KLF11 (show KLF11 ELISA Kits), NXPH1 (show NXPH1 ELISA Kits), POU4F1 (show POU4F1 ELISA Kits), SIM1 (show SIM1 ELISA Kits), and TCF7L1 (show TCF3 ELISA Kits) were >/=30% higher than in normal samples, representing potential biomarkers for tumor diagnosis.
No difference in nuclear beta-catenin (show CTNNB1 ELISA Kits) signal intensity was found, which may be caused by an alteration in Wnt (show WNT2 ELISA Kits) pathway in microsatellite stable sporadic tumors by unknown mechanisms leading to lower TCF-3 (show TCF3 ELISA Kits), 4 protein expression.
This gene encodes a member of the T cell factor/lymphoid enhancer factor family of transcription factors. These transcription factors are activated by beta catenin, mediate the Wnt signaling pathway and are antagonized by the transforming growth factor beta signaling pathway. The encoded protein contains a high mobility group-box DNA binding domain and participates in the regulation of cell cycle genes and cellular senescence.
HMG box transcription factor 3
, T-cell factor 3
, transcription factor 3
, transcription factor 7-like 1
, transcription factor 7-like 1 (T-cell specific, HMG box)
, transcription factor 7-like 2 (T-cell specific, HMG box)
, HMG box transcription factor 3-A
, transcription factor 7-like 1-A
, transcription factor XTCF-3b