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Tcf7l1 defines the border between the neural crest and the prospective forebrain via restriction of the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling gradient.
report the identification of two independent missense variants in human TCF7L1, p.R92P and p.R400Q, in a cohort of patients with forebrain and/or pituitary defects
The authors find that downstream of glycogen synthase kinase 3 (show GSK3a Proteins) inhibition, elevated cMyc (show MYC Proteins) and beta-catenin (show CTNNB1 Proteins) act in parallel to reduce transcription and DNA binding, respectively, of the transcriptional repressor Tcf7l1.
Sox4 and Tcf7l1 form a functional axis that promotes the progression of BCR-ABL (show ABL1 Proteins)-positive acute lymphoblastic leukemia.
The role of Tcf7l1 in mammals is to inhibit the gene regulatory network to ensure the coordination of lineage specification with the dynamic cellular events occurring during gastrulation.
results establish TCF7L1 as a transcriptional hub coordinating cell-cell contact with the transcriptional repression required for adipogenic competency
Tcf3-/- embryos proceed through gastrulation to form mesoderm, but they develop expanded and often duplicated axial mesoderm structures, including nodes and notochords.
E2A (show TCF3 Proteins)-PBX1 (show PBX1 Proteins) interacts directly with the KIX domain of CBP/p300 (show CREBBP Proteins) in the induction of proliferation in primary hematopoietic cells
Tcf3-mediated control of Nanog levels allows stem cells to balance the creation of lineage-committed and undifferentiated cells
These data suggest that in the absence of Wnt (show WNT2 Proteins) signals, Tcf3 may function in skin SCs (show TWIST1 Proteins) to maintain an undifferentiated state and, through Wnt (show WNT2 Proteins) signaling, directs these cells along the hair lineage.
report the identification of two independent missense variants in human TCF7L1 (show TCF3 Proteins), p.R92P and p.R400Q, in a cohort of patients with forebrain and/or pituitary defects
Data indicate that median methylation levels of BCAN (show BCAN Proteins), HOXD1 (show HOXD1 Proteins), KCTD8 (show KCTD8 Proteins), KLF11 (show KLF11 Proteins), NXPH1 (show NXPH1 Proteins), POU4F1 (show POU4F1 Proteins), SIM1 (show SIM1 Proteins), and TCF7L1 (show TCF3 Proteins) were >/=30% higher than in normal samples, representing potential biomarkers for tumor diagnosis.
No difference in nuclear beta-catenin (show CTNNB1 Proteins) signal intensity was found, which may be caused by an alteration in Wnt (show WNT2 Proteins) pathway in microsatellite stable sporadic tumors by unknown mechanisms leading to lower TCF-3 (show TCF3 Proteins), 4 protein expression.
This gene encodes a member of the T cell factor/lymphoid enhancer factor family of transcription factors. These transcription factors are activated by beta catenin, mediate the Wnt signaling pathway and are antagonized by the transforming growth factor beta signaling pathway. The encoded protein contains a high mobility group-box DNA binding domain and participates in the regulation of cell cycle genes and cellular senescence.
HMG box transcription factor 3
, T-cell factor 3
, transcription factor 3
, transcription factor 7-like 1
, transcription factor 7-like 1 (T-cell specific, HMG box)
, transcription factor 7-like 2 (T-cell specific, HMG box)
, HMG box transcription factor 3-A
, transcription factor 7-like 1-A
, transcription factor XTCF-3b