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Authors present data indicating that TLE1 is rapidly excluded from the nucleus following epidermal growth factor receptor (show EGFR Proteins) pathway activation, an effect that likely accounts for its inability to mediate effective repression under such conditions.
TLE1 is not a stand-alone diagnostic immunohistochemical marker for synovial sarcoma
Data suggest TLE1 is highly expressed in macrophages cultured in vitro, in macrophages of atherosclerotic plaques, and in macrophages of visceral adipose tissue from obese women; expression of TLE1 is up-regulated upon macrophage activat (show IL4 Proteins)ion.
TLE1 has a role in regulating epithelial-to-mesenchymal transition in A549 cells through its repressive effect on E-cadherin (show CDH1 Proteins)
There was no difference in TLE-1 staining between different subtypes of synovial sarcoma
GrG1 is involved in pancreatic cell differentiation, establishing a monohormonal beta cell identity. Grg1 is the predominant Groucho expressed in human beta-cells but acts functionally similarly to Grg3.
TCF (show HNF4A Proteins)/TLE tetramer complex promotes structural transitions of chromatin to mediate repression.
signaling and increases the expression (show NOTCH1 Proteins)of recombinant recognition sequence binding protein at the Jkappa site (RBP-J) and transducin-like enhancer of Split (show RBPJ Proteins)(TLE).
Although molecular confirmation is the diagnostic gold standard for synovial sarcoma, TLE1, in view of its high sensitivity may be a useful marker within the optimal IHC panel comprising EMA (show ETFA Proteins), BCL2 (show BCL2 Proteins), MIC2, CD34 (show CD34 Proteins) and CK7 (show KRT7 Proteins)
TLE1 is selectively upregulated in invasive breast tumors relative to noninvasive ductal carcinoma in situ and normal mammary epithelial tissues.
Data suggest that Tle1 is highly expressed in activated macrophages cultured in vitro; expression of Tle1 is low in resting macrophages and is up-regulated upon macrophage activation (here, stimulated with recombinant human interleukin-4 (show IL4 Proteins)).
Loss of Tle1 not only results in increased phosphorylation and activation of proinflammatory NF-kappaB but also results in decreased Hes1 (hairy and enhancer of split-1), a negative regulator of inflammation in macrophages
TLE1/TLE3-NuRD corepressor complex facilitates Tbx20 (show TBX20 Proteins)-dependent transcriptional repression.
Data indicate that cAMP activates Notch (show NOTCH1 Proteins) signaling and increases the expression of recombinant recognition sequence binding protein at the Jkappa site (RBP-J (show RBPJ Proteins)) and transducin (show GNAT1 Proteins)-like enhancer of Split (TLE).
Studies suggest that TLE1 and TLE3 might also play roles independent of HESX1 (show HESX1 Proteins) by interacting with other transcription factors like PROP1 (show PROP1 Proteins).
Grg1-S may operate in conjunction with beta-catenin (show CTNNB1 Proteins) and Tcf (show HNF4A Proteins) factors to regulate vertebrate gut (show GUSB Proteins) epithelial cell differentiation
Grg6 (show TLE6 Proteins) interferes with the binding of Gro (show CXCL1 Proteins)/TLE1 to BF-1 (show FOXG1 Proteins) and does not repress transcription when targeted to DNA.
Inhibition of cortical neuron differentiation by Groucho/TLE1 requires interaction with WRPW, but not Eh1 (show EPHX1 Proteins), repressor peptides
Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.
transducin-like enhancer of split 1
, transducin-like enhancer protein 1
, novel protein similar to vertebrate transducin-like enhancer family (E(sp1) homolog Drosophila)
, e(Sp1) homolog
, enhancer of split groucho 1
, enhancer of split groucho-like protein 1
, transducin-like enhancer of split 1, homolog of Drosophila E(sp1)
, groucho-related protein 1
, transducin-like enhancer of split 4 (homolog of Drosophila E(spl)) - like
, enhancer of split groucho
, transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
, transducin-like enhancer of split 3 (E(sp1) homolog) a