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In this first report of a human defect in a member of the subcortical maternal subcritical maternal complex, we show that the TLE6 mutation is gender-specific and leads to the earliest known human embryonic lethality phenotype
transcriptional programmes regulated by FOXG1 (show FOXG1 Proteins) and Groucho/TLE are important for BTIC-initiated brain tumour growth, implicating FOXG1 (show FOXG1 Proteins) and Groucho/TLE in GBM tumourigenesis
Expression of Tle6-like in colon cancer cells increased cell proliferation, colony-formation, cell migration, and xenograft tumorgenicity.
TLE6 stabilizes the subcortical maternal complex (SCMC). SCMC is required for formation of the cytoplasmic F-actin meshwork that controls the central position of the spindle and ensures symmetric division.
TLE6 localized to the oocyte cortex throughout meiosis in a manner that is spatially and temporally consistent with the localization of critical protein kinase A subunits
Grg6 is expressed in cortical neural progenitor cells, interacts with BF-1 (show FOXG1 Proteins), and plays a role in in cortical neuron development.
Results describe a subcortical maternal complex, containing Mater, Floped (show OOEP Proteins), TLE6, and Filia (show KHDC3 Proteins), that is essential for preimplantation mouse embryogenesis.
As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions (By similarity).
transducin-like enhancer protein 6
, Groucho-related protein 6