|Antigen||Wingless-Type MMTV Integration Site Family, Member 1 (WNT1) Antibodies|
|Epitope||Internal Region Alternatives|
|Reactivity||Cow (Bovine), Dog (Canine), Human, Monkey, Mouse (Murine), Opossum (Didelphimorphia), Rat (Rattus) Alternatives|
|Conjugate||This WNT1 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Western Blotting (WB)
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Product Details anti-WNT1 AntibodyTarget Details WNT1 Application Details Handling Images
|Specificity||This antibody reacts with Wnt1 protein.|
Species reactivity (expected):Rat, Bovine, Canine, Macaque, Opossum.
Species reactivity (tested):Human, Mouse.
|Characteristics||Concentration: 1.38 mg/mL (by UV absorbance at 280 nm)|
|Immunogen||Synthetic peptide corresponding to an internal region of Human Wnt1 protein|
Target Details WNT1Product Details anti-WNT1 Antibody Application Details Handling Images back to top
|Alternative Name||WNT1 (WNT1 Antibody Abstract)|
|Background||The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Wnt1 (Wingless-type MMTV integration site family member 1) is a member of the WNT gene family. It is highly conserved in evolution and the protein encoded by this gene is known to be 98 % identical to mouse Wnt1 protein at the amino acid level. Studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. Wnt1 is secreted as an extracellular matrix protein.Synonyms: INT-1, INT1, Proto-oncogene protein Wnt-1|
|Pathways||WNT Signaling, Dopaminergic Neurogenesis|
Application DetailsProduct Details anti-WNT1 Antibody Target Details WNT1 Handling Images back to top
ELISA: 1/25,000. Western Blot: 1/1,500 - 1/6,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-WNT1 Antibody Target Details WNT1 Application Details Images back to top
|Buffer||0.02 M Potassium Phosphate, 0.12 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide as preservative|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|