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AT2R (show AGTR2 Proteins) inhibits adipogenic differentiation in mesenchymal stem cells. Moreover, this inhibitory effect is associated with Wnt10b/beta-catenin (show CTNNB1 Proteins) signaling.
XBP1s can regulate Wnt10b by a post-transcriptional mechanism through directly inducing microRNA-148a.
findings suggest that Wnt10b plays an important role in regulating asthmatic airway inflammation through modification of the T cell response and is a prospective target in the disease process
Data show that Wnt protein Wnt10b is expressed in cardiomyocytes and localized in the intercalated discs of mouse and human hearts.
Oleuropein protects mice from gh-fat diet induced adiposity by upregulation of genes involved in WNT10b-mediated signaling and downregulation of genes involved in galanin (show GAL Proteins)-mediated signaling cascades.
results suggest that Wnt (show WNT2 Proteins)-10b represses tumor cell properties, such as proliferation and migration of B16 melanoma cells, driving them toward a more differentiated state along a melanocyte lineage
Wnt10b/DKK1 (show DKK1 Proteins) can modulate hair follicle size during hair regeneration.
In senescent osteopenic mice, blocking the CADH2-Wnt (show WNT2 Proteins) interaction using an antagonist peptide increased Wnt5a (show WNT5A Proteins) and Wnt10b expression, bone formation, and bone mass.
Hypoxia-inducible factor-2alpha-dependent hypoxic induction of Wnt10b expression in adipogenic cells.
Data suggest that Tgfb1 (transforming growth factor beta 1 (show TGFB1 Proteins)) induces Wnt10b in osteoclasts; induction of Wnt10b may enhance restoration of bone lost during bone turnover and may explain osteoclast stimulation of osteoblast-directed mineralization.
this study provides novel insight into the mechanism of action of parathyroid hormone (show PTH Proteins) on human periodontal ligament cells and establish their interplay with T cells via the Wnt10b pathway as a modulating factor for the anabolic properties of the hormone in periodontal regeneration
findings provide the identification of autosomal-dominant WNT10B mutations in individuals with oligodontia, which increases the spectrum of congenital tooth agenesis and suggests attenuated Wnt (show WNT2 Proteins) signaling in endothelial differentiation of dental pulp stem cells.
these findings clearly demonstrate that Wnt10b promotes epidermal keratinocyte transformation through induced Egf (show EGF Proteins) pathway
WNT10B enhances proliferation through beta-catenin (show CTNNB1 Proteins) and RAC1 GTPase (show RACGAP1 Proteins) in human corneal endothelial cells.
Sequence analysis of WNT10B gene revealed a novel 4-bp deletion mutation.
No association between WNT10B polymorphisms and adiposity parameters was found. However, a role for WNT10B variants in determining human bone mineral density was found.
Variations in WNT10B do not contribute to human monogenic obesity in our population.
we identified WNT10B as a direct target of miR (show MLXIP Proteins)-148a in cancer-associated fibroblasts from endometrial cancers
Results indicate that the porcine WNT10B gene may be a very important candidate gene for porcine backfat thickness.
wnt1 (show WNT1 Proteins) and wnt10b are required to maintain threshold levels of Pax2.1 and Fgf8 (show FGF8 Proteins) at the midbrain-hindbrain boundary.
In zebrafish embryos lacking Wnt3a (show WNT3A Proteins), Wnt1 (show WNT1 Proteins) and Wnt10b, the expression of engrailed orthologs, pax2a and fgf8 (show FGF8 Proteins) is not maintained after mid-somitogenesis
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It may be involved in breast cancer, and its protein signaling is likely a molecular switch that governs adipogenesis. This protein is 96% identical to the mouse Wnt10b protein at the amino acid level. This gene is clustered with another family member, WNT1, in the chromosome 12q13 region.
wingless-type MMTV integration site family, member 10B
, protein Wnt-10b
, WNT-10B protein
, wingless related MMTV integration site 10b
, Protein Wnt-10
, wnt-1 related (wnt-10), wingless-type MMTV integration site family