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Wnt16 controls a novel genetic regulatory network required for HSC (show FUT1 Proteins) specification
genomic analysis of conserved sequences between human, rat, and zebrafish WNT16
WNT16 antagonises excessive canonical WNT (show WNT2 Proteins) activation and protects cartilage in osteoarthritis.
Wnt16 Is Associated with Age-Related Bone Loss and Estrogen Withdrawal in Murine Bone
Describe TGFbeta (show TGFB1 Proteins)-Wnt16-Notch (show NOTCH1 Proteins) signaling conduit in the chondrocyte-like transformation of VSMCs and identify endogenous TGFbeta (show TGFB1 Proteins) activity in MGP (show MGP Proteins)-null VSMCs as a critical mediator of chondrogenesis.
Wnt5a (show WNT5A Proteins) abrogated the inhibitory effects of Wnt16 on Rankl (show TNFSF11 Proteins)-induced osteoclastogenesis
These findings suggest that WNT16 acting via canonical WNT (show WNT2 Proteins) signaling regulates mechanical strain-induced periosteal bone formation and bone size.
Osteoblast-derived WNT16 is a previously unreported key regulator of osteoclastogenesis and fracture susceptibility.
Wnt16 is involved in intramembranous ossification and suppresses osteoblast differentiation through the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathway.
Study revealed new domains of expression for Wnt2 (show WNT2 Proteins), Wnt2b (show WNT2B Proteins), Wnt5b (show WNT5B Proteins), Wnt6 (show WNT6 Proteins), Wnt7b (show WNT7B Proteins), Wnt9a (show WNT9A Proteins), Wnt10a (show WNT10A Proteins), Wnt10b (show WNT10B Proteins), Wnt11 (show WNT11 Proteins) and Wnt16, in the limb.
the upregulation of autophagy-related gene (Atg) and wingless/int1 (show WNT1 Proteins) (Wnt (show WNT2 Proteins)) signaling during BMP-2 (show BMP2 Proteins)-mediated human osteoblastic differentiation, was examined.
PRKX (show PRKX Proteins), WNT3 (show WNT3 Proteins) and WNT16 genes, belonging to the WNT (show WNT2 Proteins) signaling pathway, are involved in the tumorigenic process of nodular basal cell carcinoma
ThE findingS suggests that WNT16 might be an important genetic factor in determining peak bone mass acquisition.
Although in vitro studies demonstrated no differences in expressions of wild-type and mutant forms of IDUA (show IDUA Proteins) and WNT16B proteins, in silico analyses predicts that WNT16 rs2707466 directly abolishes a phosphorylation site, which could cause a deleterious effect on WNT16 protein.
MicroRNA-374b Suppresses Proliferation and Promotes Apoptosis in T-cell Lymphoblastic Lymphoma by Repressing AKT1 (show AKT1 Proteins) and Wnt-16
Data indicate that WNT16 is critical for positive regulation of both cortical and trabecular bone mass and structure. WNT16-TG mice exhibited significantly higher whole-body areal bone mineral density and bone mineral content.
ALL cells expressing WNT16 are sensitive to endoplasmic reticulum stress, and show enhanced killing after addition of chloroquine.
loss of endogenous WNT16 results specifically in cortical bone loss, whereas overexpression of WNT16 surprisingly increases mainly trabecular bone mass.
variants at WNT16 were more strongly related to upper limb-bone mineral density, than to bone mineral density at the other sites.
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It contains two transcript variants diverging at the 5' termini. These two variants are proposed to be the products of separate promoters and not to be splice variants from a single promoter. They are differentially expressed in normal tissues, one of which (variant 2) is expressed at significant levels only in the pancreas, whereas another one (variant 1) is expressed more ubiquitously with highest levels in adult kidney, placenta, brain, heart, and spleen.
wingless-type MMTV integration site family, member 16
, protein Wnt-16
, protein Wnt-16-like
, wingless-type MMTV integration site family member 16
, wingless-type MMTV integration site family member 16b
, wingless-related MMTV integration site 16