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Data suggest that Wnt3 (show WNT3A ELISA Kits), Wnt3a (show WNT3A ELISA Kits), and Wnt8a (show WNT8A ELISA Kits) bind to their respective receptors (Fz8 (show FZD2 ELISA Kits), Lrp6 (show LRP5 ELISA Kits), and Lypd6 (show LYPD6 ELISA Kits)) in ordered plasma membrane environments; ordered plasma membrane environments appear to be essential for binding of Wnt (show WNT2 ELISA Kits) proteins to their receptor complexes and stimulation of downstream signaling activity.
Wnt3 (show WNT3A ELISA Kits) is associated with cholesterol-dependent domains
WNT3 (show WNT3A ELISA Kits) involvement in human bladder exstrophy and cloaca development in zebrafish
Study demonstrates that Wnt3 (show WNT3A ELISA Kits) regulates cerebellum development during embryogenesis using zebrafish wnt3 (show WNT3A ELISA Kits) transgenics with either tissue-specific expression of an EGFP reporter or a functionally active fusion protein, Wnt3EGFP.
We have identified canonical Wnt (show WNT2 ELISA Kits) signaling as a novel pathway, that is required for proper formation of the mid-diencephalic organizer and consequently for the development of the major relay station of the brain - the thalamus.
Wnt3 (show WNT3A ELISA Kits) participates in processes such as forebrain compartmentalization and regulation of tectal wiring topography by retinal ganglia axons.
these results therefore highlight an unanticipated role for p53 (show TP53 ELISA Kits) family proteins in a regulatory network that integrates essential Wnt (show WNT2 ELISA Kits)-Tcf (show HNF4A ELISA Kits) and nodal-Smad (show SMAD1 ELISA Kits) inputs.
stem-cell membranes constitute a reservoir for Wnt (show WNT2 ELISA Kits) proteins, while Frizzled receptor turnover and 'plasma membrane dilution' through cell division shape the epithelial Wnt3 gradient
timed secretion of wnt3 by ingrowing axons from the thalamus regulates the combinatorial composition of ribosomal proteins in developing neocortex. WNT3 further regulates the specificity of mRNA translation and development of neurons and oligodendrocytes.
this article shows that absence of Wnt3 in the posterior visceral endoderm leads to delayed formation of the primitive streak and that interplay between anterior and posterior visceral endoderm restricts the position of the primitive streak
Data indicate that functional Wnt3/beta-Catenin (show CTNNB1 ELISA Kits) signaling is localized to the dorsal subventricular zone (SVZ) microdomain.
Wnt3 is part of a signaling loop that affects homeostasis of intestinal stem and Paneth cells in mice.
Wnt3 function in the epiblast is required for the maintenance but not the initiation of gastrulation in mice
canonical Wnt (show WNT2 ELISA Kits) signaling regulates CXCL12 (show CXCL12 ELISA Kits) gene expression at the transcriptional level
Wnt-3a (show WNT3A ELISA Kits) and Wnt-3 factors signal through the canonical Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) pathway to regulate different aspects of spinal cord neural progenitor development.
The mRNA levels of Wnt3, 6, and 9a were significantly upregulated in the intestinal epithelial cells by Salmonella.
Wnt3 is associated with cholesterol-dependent domains
analysis of WNT3 expression in CLL patients demonstrated that (i) untreated patients with more aggressive disease (with a notable exception of patients with 11q deletion) express less WNT3, (ii) WNT3 declines with disease progression in a significant proportion of patients and (iii) low WNT3 was identified as a strong independent marker indicating shorter treatment-free survival in CLL patients with IGHV mutation.
PRKX (show PRKX ELISA Kits), WNT3 and WNT16 (show WNT16 ELISA Kits) genes, belonging to the WNT (show WNT2 ELISA Kits) signaling pathway, are involved in the tumorigenic process of nodular basal cell carcinoma
Two SNPs (rs3809857 and rs9890413) in the WNT3 gene were subjected to case-control and case-parent analysis
WNT3 and membrane-associated beta-catenin (show CTNNB1 ELISA Kits) regulate trophectoderm lineage differentiation in human blastocysts.
WNT3 involvement in human bladder exstrophy and cloaca development in zebrafish
Genome association study shows a highly conserved 32 kb intergenic region containing regulatory elements between WNT3 and WNT9B (show WNT9B ELISA Kits) in patients with classic bladder exstrophy.
mRNA level of WNT3 in hESCs correlates with their definitive ectoderm differentiation efficiency.
Data show that the WNT (show WNT2 ELISA Kits)/beta-CATENIN (show CTNNB1 ELISA Kits) signaling cascade components, including WNT (show WNT2 ELISA Kits) ligands WNT3 and WNT5A (show WNT5A ELISA Kits), is crucial for early odontogenesis.
WNT3 inhibits cerebellar granule neuron progenitor proliferation and medulloblastoma formation via MAPK (show MAPK1 ELISA Kits) activation.
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. This gene is clustered with WNT15, another family member, in the chromosome 17q21 region.
, wingless-type MMTV integration site family member 3
, wingless-type MMTV integration site family, member 3
, wingless-related MMTV integration site 3A
, proto-oncogene Wnt-3-like
, proto-oncogene Int-4
, proto-oncogene protein Wnt-3
, WNT-3 proto-oncogene protein
, proto-oncogene Int-4 homolog
, Wingless-type MMTV integration site 3, homolog
, wingless-related MMTV integration site 3
, Xwnt-3 region near C-terminus