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dSETDB1 is required for the expression of a Wnt ligand, Drosophila Wingless type mouse mammary virus integration site number 4 (dWnt4) in the somatic niche.
this study identifies a transcriptional switch involving the kinase Btk29A/Btk and its phosphorylation target, beta-catenin, which functions downstream of Wnt4 in escort cells to terminate Drosophila germ cell proliferation through up-regulation of piwi expression.
Wg and Wnt4 act redundantly in planar cell polarity determination in Drosophila.
We re-evaluated the expression pattern of DWnt4 during embryogenesis and show that transcripts are not restricted to the dorsal ectoderm but are also present in the cardiogenic mesoderm.
In Drosophila, Otk interacts with Wnt4 and opposes canonical Wnt signalling in embryonic patterning.
DWnt4 regulates cell movement and focal adhesion kinase during Drosophila ovarian morphogenesis.
DWnt4 antagonizes the polarizing effect of four-jointed
in DWnt4 mutants, ventral retinal axons misprojected to the dorsal lamina
Data indicate that a balance between supporting cell (show PTPRJ ELISA Kits) self-renewal and differentiation is maintained in the developing ovary by relative Wnt4 protein/beta-catenin (show CTNNB1 ELISA Kits) and p27Kip1 (show CDKN1B ELISA Kits) protein (p27 (show CDKN1B ELISA Kits))/Forkhead box L2 (FOXL2 (show FOXL2 ELISA Kits)) activities.
decreased expression of Wnt4 in the aging thymus may be one of the molecular triggers underlying the process of age-related thymic senescence.
Mir (show MLXIP ELISA Kits)-29c regulates WNT4 signaling.
Wnt4 is essential to normal mammalian lung development.
RSPO1 (show RSPO1 ELISA Kits), WNT4, and beta-catenin (show CTNNB1 ELISA Kits) have roles in the signaling pathway during ovarian differentiation in mice.
The Runx-1 (show RUNX1 ELISA Kits) gene can be a Wnt-4 signalling target, and that Runx-1 (show RUNX1 ELISA Kits) and Wnt-4 are mutually interdependent in their expression.
Progesterone and Wnt4 control stem cell function through a luminal-myoepithelial crosstalk with Wnt4 acting independent of progesterone receptor (show PGR ELISA Kits) perinatally.
study presents for the first time that estrogen regulates Egr1 (show EGR1 ELISA Kits) expression through LIF (show LIF ELISA Kits)-STAT3 (show STAT3 ELISA Kits) signaling pathway in mouse uterus, and Egr1 (show EGR1 ELISA Kits) functions as a critical mediator of stromal cell decidualization by regulating Wnt4
results suggest that Wnt4 signaling could be an attractive therapeutic target for treating osteoporosis and preventing skeletal aging
Data indicate that Wnt4 signaling is necessary during maturation of the ovarian follicle.
Polymorphisms on WNT4 gene might be involved in the pathogenesis of endometriosis in the infertile women.
the expression of WNT4, a Wnt (show WNT2 ELISA Kits) ligand, and three targets of Wnt (show WNT2 ELISA Kits)-ss-catenin transcription activation, namely, MMP7 (show MMP7 ELISA Kits), cyclinD1 (CD1 (show CD1A ELISA Kits)) and c-MYC (show MYC ELISA Kits) in 141 penile tissue cores from 101 unique samples, were investigated.
The results demonstrated that WNT4 rs2235529 is associated with endometriosis in Chinese Han women, which may result in aberrant expression of WNT4, leading to the pathogenesis of endometriosis.
Wnt4 might be a key gene during parathyroid hormone (show PTH ELISA Kits)-induced epithelial mesenchymal transformation of proximal kidney tubule cells.
The 5'-flanking region of the Wnt4 gene is responsive to Pax8 (show PAX8 ELISA Kits). Pax8 (show PAX8 ELISA Kits) modulates the expression of Wnt4 in thyroid cells.
Our results suggest that the rs10965235 SNP in the CDKN2B (show CDKN2B ELISA Kits)-AS gene and the rs16826658 SNP near the WNT4 gene were significantly associated with endometriosis in this Korean population.
We report an adolescent girl with the cardinal (show CARD8 ELISA Kits) features of MURCS association, obesity, and clinical findings of hyperandrogenism who did not show any exonic mutation of the WNT4 gene
These data indicate that Wnt4 signaling is deregulated in most pituitary adenomas and its excessive activation may inhibit pituitary tumor invasion.
State anxiety assessed two months before the examination was positively and negatively correlated with miR-16 (show GDE1 ELISA Kits) and its target WNT4 mRNA levels, respectively.
The WNT4 ligand plays a role in regulating the cell growth of leukemia-derived cells by arresting cells in the G1 cell cycle phase.
identified Wnt4 as the ligand that is expressed in the mesoderm of the ventral blood island and is essential for the expression of hematopoietic and erythroid marker genes
XWntless and the Retromer complex are required for the efficient secretion of XWnt4, facilitating its role in Xenopus eye development
Study shows that Wnt-4 acts through the Notch (show NOTCH1 ELISA Kits) effector gene hrt1 (show HEY1 ELISA Kits) by upregulating expression of wnt4; Wnt-4 then patterns the proximal pronephric anlagen to establish the specific compartments that span the medio-lateral axis.
Data show that in vivo, wnt11r (show WNT11 ELISA Kits) and wnt4a initiate MuSK (show MUSK ELISA Kits) translocation from muscle membranes to recycling endosomes and that this transition is crucial for AChR accumulation at future synaptic sites.
Data show that injury-dependent induction of Ascl1a suppressed expression of the Wnt (show WNT2 ELISA Kits) signaling inhibitor, Dkk (show DKK1 ELISA Kits), and induced expression of the Wnt (show WNT2 ELISA Kits) ligand, Wnt4a.
Findings provide the first convincing line of evidence that EAF and Wnt4 form an auto-regulatory negative feedback loop in vivo.
three Wnt (show WNT2 ELISA Kits) noncanonical ligands wnt4a, silberblick/wnt11 (show WNT11 ELISA Kits), and wnt11 (show WNT11 ELISA Kits)-related regulate the process of convergence of endoderm and organ precursors toward the embryonic midline by acting in a largely redundant way
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and is the first signaling molecule shown to influence the sex-determination cascade. It encodes a protein which shows 98% amino acid identity to the Wnt4 protein of mouse and rat. This gene and a nuclear receptor known to antagonize the testis-determining factor play a concerted role in both the control of female development and the prevention of testes formation. This gene and another two family members, WNT2 and WNT7B, may be associated with abnormal proliferation in breast tissue. Mutations in this gene can result in Rokitansky-Kuster-Hauser syndrome and in SERKAL syndrome.
, wingless-type MMTV integration site family, member 4
, protein Wnt-4
, signal molecule
, wingless-related MMTV integration site 4
, Wnt-4 protein
, protein Wnt-4a