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disruption of Wnt4 and components of the canonical Wnt pathway results in a complex germ cell phenotype marked by an expansion of germline stem cell-like cells, pre-cystoblasts and cystoblasts in young females.
Wnt4 and the canonical Wnt signaling pathway are essential for ostia formation in Drosophila
dSETDB1 is required for the expression of a Wnt ligand, Drosophila Wingless type mouse mammary virus integration site number 4 (dWnt4) in the somatic niche.
this study identifies a transcriptional switch involving the kinase Btk29A/Btk and its phosphorylation target, beta-catenin, which functions downstream of Wnt4 in escort cells to terminate Drosophila germ cell proliferation through up-regulation of piwi expression.
Wg and Wnt4 act redundantly in planar cell polarity determination in Drosophila.
We re-evaluated the expression pattern of DWnt4 during embryogenesis and show that transcripts are not restricted to the dorsal ectoderm but are also present in the cardiogenic mesoderm.
In Drosophila, Otk interacts with Wnt4 and opposes canonical Wnt signalling in embryonic patterning.
DWnt4 regulates cell movement and focal adhesion kinase during Drosophila ovarian morphogenesis.
DWnt4 antagonizes the polarizing effect of four-jointed
in DWnt4 mutants, ventral retinal axons misprojected to the dorsal lamina
Results suggest that the Wnt4 gene encodes signals that are important for various aspects of female reproductive tract development.
Our functional study revealed that WNT4 molecules were involved in regulating zygotic cleavage and early embryogenesis
Data indicate that a balance between supporting cell (show PTPRJ Proteins) self-renewal and differentiation is maintained in the developing ovary by relative Wnt4 protein/beta-catenin (show CTNNB1 Proteins) and p27Kip1 (show CDKN1B Proteins) protein (p27 (show CDKN1B Proteins))/Forkhead box L2 (FOXL2 (show FOXL2 Proteins)) activities.
decreased expression of Wnt4 in the aging thymus may be one of the molecular triggers underlying the process of age-related thymic senescence.
Mir (show MLXIP Proteins)-29c regulates WNT4 signaling.
Wnt4 is essential to normal mammalian lung development.
RSPO1 (show RSPO1 Proteins), WNT4, and beta-catenin (show CTNNB1 Proteins) have roles in the signaling pathway during ovarian differentiation in mice.
The Runx-1 (show RUNX1 Proteins) gene can be a Wnt-4 signalling target, and that Runx-1 (show RUNX1 Proteins) and Wnt-4 are mutually interdependent in their expression.
Progesterone and Wnt4 control stem cell function through a luminal-myoepithelial crosstalk with Wnt4 acting independent of progesterone receptor (show PGR Proteins) perinatally.
study presents for the first time that estrogen regulates Egr1 (show EGR1 Proteins) expression through LIF (show LIF Proteins)-STAT3 (show STAT3 Proteins) signaling pathway in mouse uterus, and Egr1 (show EGR1 Proteins) functions as a critical mediator of stromal cell decidualization by regulating Wnt4
The etiology of MRKH syndrome is still largely unknown, probably because of its intrinsic heterogeneity. Several candidate causative genes have been investigated, but to date only WNT4 has been associated with MRKH with hyperandrogenism. This review summarizes and discusses the clinical features and details progress to date in understanding the genetics of MRKH syndrome.
We highlight the cooperation of WNT4, RSPO1 (show RSPO1 Proteins) and FOXL2 (show FOXL2 Proteins) within a regulatory network and the need for further research to better understand their role in defining and maintaining ovarian identity.
The WNT4 expression level in eutopic endometrium was significantly reduced compared with that in normal endometrium of the control group.
Studied the roles of WNT4 and WNT5A (show WNT5A Proteins) in human decidulization and their relationship with preeclampsia.
Polymorphisms on WNT4 gene might be involved in the pathogenesis of endometriosis in the infertile women.
the expression of WNT4, a Wnt (show WNT2 Proteins) ligand, and three targets of Wnt (show WNT2 Proteins)-ss-catenin transcription activation, namely, MMP7 (show MMP7 Proteins), cyclinD1 (CD1 (show CD1A Proteins)) and c-MYC (show MYC Proteins) in 141 penile tissue cores from 101 unique samples, were investigated.
The results demonstrated that WNT4 rs2235529 is associated with endometriosis in Chinese Han women, which may result in aberrant expression of WNT4, leading to the pathogenesis of endometriosis.
Wnt4 might be a key gene during parathyroid hormone (show PTH Proteins)-induced epithelial mesenchymal transformation of proximal kidney tubule cells.
The 5'-flanking region of the Wnt4 gene is responsive to Pax8 (show PAX8 Proteins). Pax8 (show PAX8 Proteins) modulates the expression of Wnt4 in thyroid cells.
identified Wnt4 as the ligand that is expressed in the mesoderm of the ventral blood island and is essential for the expression of hematopoietic and erythroid marker genes
XWntless and the Retromer complex are required for the efficient secretion of XWnt4, facilitating its role in Xenopus eye development
Study shows that Wnt-4 acts through the Notch (show NOTCH1 Proteins) effector gene hrt1 (show HEY1 Proteins) by upregulating expression of wnt4; Wnt-4 then patterns the proximal pronephric anlagen to establish the specific compartments that span the medio-lateral axis.
single inhibition of melatonin receptor 1 or Wnt-4 expression decreased expression of neurogenesis-related genes, and bovine amniotic epithelial cell-derived neural cells were successfully colonized into injured spinal cord, which suggested participation in tissue repair.
Data show that in vivo, wnt11r (show WNT11 Proteins) and wnt4a initiate MuSK (show MUSK Proteins) translocation from muscle membranes to recycling endosomes and that this transition is crucial for AChR accumulation at future synaptic sites.
Data show that injury-dependent induction of Ascl1a suppressed expression of the Wnt (show WNT2 Proteins) signaling inhibitor, Dkk (show DKK1 Proteins), and induced expression of the Wnt (show WNT2 Proteins) ligand, Wnt4a.
Findings provide the first convincing line of evidence that EAF and Wnt4 form an auto-regulatory negative feedback loop in vivo.
three Wnt (show WNT2 Proteins) noncanonical ligands wnt4a, silberblick/wnt11 (show WNT11 Proteins), and wnt11 (show WNT11 Proteins)-related regulate the process of convergence of endoderm and organ precursors toward the embryonic midline by acting in a largely redundant way
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and is the first signaling molecule shown to influence the sex-determination cascade. It encodes a protein which shows 98% amino acid identity to the Wnt4 protein of mouse and rat. This gene and a nuclear receptor known to antagonize the testis-determining factor play a concerted role in both the control of female development and the prevention of testes formation. This gene and another two family members, WNT2 and WNT7B, may be associated with abnormal proliferation in breast tissue. Mutations in this gene can result in Rokitansky-Kuster-Hauser syndrome and in SERKAL syndrome.
, wingless-type MMTV integration site family, member 4
, protein Wnt-4
, signal molecule
, wingless-related MMTV integration site 4
, Wnt-4 protein
, protein Wnt-4a