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Human WNT9A Protein expressed in Wheat germ - ABIN1325373
Kulawig, Krüger, Klein, Konthur, Schütte, Klose, Kaps, Endres: Identification of fibronectin as a major factor in human serum to recruit subchondral mesenchymal progenitor cells. in The international journal of biochemistry & cell biology 2013
the chaperon Wls (show WLS Proteins) and its ligands Wnt9a and Wnt5b (show WNT5B Proteins) are expressed in the ectoderm, whereas juxtaposed chondrocytes express Frzb (show FRZB Proteins) and Gpc4 (show GPC4 Proteins).
disruption of wls (show WLS Proteins) resulted in a significant loss of craniofacial bone, whereas lack of gpc4 (show GPC4 Proteins), wnt5b (show WNT5B Proteins) and wnt9a resulted in severely delayed endochondral ossification.
These data corroborate the central role for Wnt (show WNT2 Proteins) signaling in vertebrate craniofacial development.
Wnt9a is expressed in the embryonic pancreas and that its deficiency enhances activation of the endocrine transcriptional program and increases the number of endocrine cells at birth.
These studies reveal how carrageenan exposure can lead to transcriptional events in colonic epithelial cells through decline in arylsulfatase B (show ARSB Proteins) activity, with subsequent impact on C4S (show CHST11 Proteins), galectin-3 (show LGALS3 Proteins), Sp1 (show SP1 Proteins), and Wnt9A
The mRNA levels of Wnt3 (show WNT3 Proteins), 6, and 9a were significantly upregulated in the intestinal epithelial cells by Salmonella.
Embryos double-heterozygous for Wnt9a and beta-catenin (show CTNNB1 Proteins) show reduced Ihh (show IHH Proteins) expression.
This manipulation increased one type of sensory hair cell (tall HCs (show HLCS Proteins)) at the expense of another (short HCs (show HLCS Proteins)) that is usually located furthest from the Wnt9a source. The extraneous tall HCs (show HLCS Proteins) that replaced short HCs (show HLCS Proteins) showed some physiological properties and neuronal connections consistent with a fate switch.
Inhibition of WNT (show WNT2 Proteins) signaling by the PORCN (show PORCN Proteins) inhibitor WNT974 reduced metastatic spread of UM-SCC (show CYP11A1 Proteins) cells, especially in UM-SCCs with Notch1 (show NOTCH1 Proteins) deficiency.
Silencing Wnt9A increased the expression of CHST11 (show CHST11 Proteins) in the colonic epithelial cells, and chromatin immunoprecipitation assay demonstrated enhancing effects of Wnt9A siRNA and exogenous BMP4 (show BMP4 Proteins) on the CHST11 (show CHST11 Proteins) promoter
These studies reveal how carrageenan exposure can lead to transcriptional events in colonic epithelial cells through decline in arylsulfatase B (show ARSB Proteins) activity, with subsequent impact on C4S (show CHST11 Proteins), galectin-3 (show LGALS3 Proteins), Sp1 (show PSG1 Proteins), and Wnt9A
Transgenic wnt9a is required for palatal extension wherein the chondrocytes form a proliferative front, undergo morphological change and intercalate to form the ethmoid plate.
Using DirectDNA sequencing analysis, we detected ATBF1, CYLD (show CYLD Proteins), PARK2 (show PARK2 Proteins) and WNT9A mutations in stomach and colorectal cancers
Results demonstrated significant up-regulation of WNT-3 (show WNT3 Proteins), WNT-4 (show WNT4 Proteins), WNT-5B (show WNT5B Proteins), WNT-7B (show WNT7B Proteins), WNT-9A, WNT-10A (show WNT10A Proteins), and WNT (show WNT2 Proteins)-16B in patients with CLL compared to normal subjects.
Found clustered with WNT3A (show WNT3A Proteins) on 1q42. .
5'-flanking promoter region was significantly divergent between human WNT9A and rodent Wnt9a genes.
These results suggests the expression level of human Wnt9a in MCF-7 that breast cancer may play a role in adjusting the rate of cellular proliferation.
The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is expressed in gastric cancer cell lines. The protein encoded by this gene shows 75% amino acid identity to chicken Wnt14, which has been shown to play a central role in initiating synovial joint formation in the chick limb. This gene is clustered with another family member, WNT3A, in the chromosome 1q42 region.
wingless-type MMTV integration site family, member 9A
, protein Wnt-9a
, protein Wnt-9a-like
, wingless-type MMTV integration site 14
, wingless-type MMTV integration site family, member 14
, wingless related MMTV integration site 9A
, wingless-type MMTV integration site 9A