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NT5C3 encodes a member of the 5'-nucleotidase family of enzymes that catalyze the dephosphorylation of nucleoside 5'-monophosphates. Additionally we are shipping 5'-Nucleotidase, Cytosolic III Antibodies (24) and 5'-Nucleotidase, Cytosolic III Proteins (7) and many more products for this protein.
polymerization of the Phc2 SAM (show TTN ELISA Kits) domain is required for PRC1 (show PRC1 ELISA Kits) clustering, chromatin condensation and gene silencing.
Phc2 may act as a negative regulator that inhibits the activity of Th cells.
report describes the first X-ray structure of a catalytically inactivated variant of murine cN-III with a natural substrate, uridine 5'-monophosphate, in the active site at 1.74A resolution
functional overlap between Phc2 and Phc1 (show PHC1 ELISA Kits) along with a strict dose-dependent requirement during anterior-posterior (A-P) patterning
reduced expression of transketolase (show TKT ELISA Kits) in pyrimidine 5'-nucleotidase (show NT5E ELISA Kits) deficient patients
Pyrimidine-5'-nucleotidase (show NT5E ELISA Kits) Campinas is a new mutation (p.R56G) in the NT5C3 gene associated with pyrimidine-5'-nucleotidase (show NT5E ELISA Kits) type I deficiency.
Results show that NT5C3 expression levels were significantly increased in patients with risk allele homozygote.
New missense homozygous mutation (Q270Ter) in the pyrimidine 5' nucleotidase (show NT5E ELISA Kits) type I-related gene in two Indian families with hereditary non-spherocytic hemolytic anemia.
analysis of Drosophila and human 7-methyl GMP (show NT5C2 ELISA Kits)-specific nucleotidases
Data show that PN-I shows a higher affinity for oxynucleosides rather than deoxynucleosides, while the opposite is true for PN-II.
These data highlight hUMP1/POMP (show POMP ELISA Kits) role in proteasome assembly and further strengthen the prospect of genetic manipulation of the proteasomal system.
In leukoblasts from 82 patients with acute myeloid leukemia (show BCL11A ELISA Kits), various extent and frequency of differential allelic expression in the CDA (show CDA ELISA Kits), DCK (show DCK ELISA Kits), NT5C2 (show NT5C2 ELISA Kits), NT5C3, and TP53 (show TP53 ELISA Kits) genes was observed.
genetic variation in NT5C3 might affect protein function and potentially influence drug response
This gene encodes a member of the 5'-nucleotidase family of enzymes that catalyze the dephosphorylation of nucleoside 5'-monophosphates. The encoded protein is the type 1 isozyme of pyrimidine 5' nucleotidase and catalyzes the dephosphorylation of pyrimidine 5' monophosphates. Mutations in this gene are a cause of hemolytic anemia due to uridine 5-prime monophosphate hydrolase deficiency. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and pseudogenes of this gene are located on the long arm of chromosomes 3 and 4.
5'-nucleotidase, cytosolic III
, cytosolic 5'-nucleotidase 3
, cytosolic 5'-nucleotidase 3A
, cytosolic 5'-nucleotidase III
, pyrimidine 5'-nucleotidase 1
, 5'-nucleotidase, pyrimidine
, uridine monophosphatase 1
, uridine 5'-monophosphate hydrolase 1
, early development regulator 2
, early development regulatory protein 2
, polyhomeotic 2 protein
, polyhomeotic-like protein 2