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The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell.
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the physiological role of the negative crosstalk between the cAMP/PKA/AKAP4 and the PKC/ERK1/2 (show MAPK1/3 ELISA Kits) pathways is to regulate capacitation and acrosome reaction.
AKAP4 role in the proliferation and metastasis of thyroid cancer.AKAP4 is highly expressed in thyroid cancer.
AKAP4 appears to be a novel Colorectal cancer-associated antigen with a potential for developing as a new clinical therapeutic target
AKAP4 is a highly accurate biomarker for the detection of early stage lung cancer.
SP17 (show SPA17 ELISA Kits)/AKAP4/PTTG1 (show PTTG1 ELISA Kits) are expressed in both human NSCLC cell lines and primary tumors and can elicit an immunogenic response in lung cancer patients.
The putative role of AKAP4 in early tumorigenesis is implicated as a biomarker and immunotherapeutic target for cervical cancer.
Ablation of AKAP4 protein caused significant inhibition in cellular proliferation, colony-forming ability, migration and invasion ability of tumor cells.
data suggests that AKAP4 may be used as serum based diagnostic test for an early detection and diagnosis of breast cancer and may be a potential target for immunotherapeutic use
We demonstrate the aberrant expression of AKAP-4 in prostate cancer, which will potentially be developed as a biomarker in prostate cancer.
AKAP4 is a novel target for protein S-nitrosylation in spermatozoa.
we validated the use of AKAP-4 antigen to track tumor growth in vivo and to specifically identify MM cells in mouse tissues.
Targeted disruption of the Akap4 gene causes defects in sperm flagellum and motility.
AKAP4 has a major role in completing fibrous sheath assembly
the distribution of AKAP4 was dependent on the microtubular cytoskeleton.
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is localized to the sperm flagellum and may be involved in the regulation of sperm motility. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
A-kinase anchor protein 4
, A kinase (PRKA) anchor protein 4
, A-kinase anchor protein 82 kDa
, cancer/testis antigen 99
, major sperm fibrous sheath protein
, protein kinase A anchoring protein 4
, protein kinase A-anchoring protein 4
, testis-specific gene HI
, AKAP 82
, 75 kDa fibrous sheath protein