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AKAP8 encodes a member of the A-kinase anchor protein family.
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Results suggest that ALK generated by alternative transcription Initiation induces chromatin structural changes and heterochromatinization through phosphorylation of AKAP8 in the nucleus.
Using a BioID proximity-based proteomic screen, we identify the nuclear pore complex protein TPR as a novel AKAP95 binding partner. We show interaction between AKAP95 and TPR in mitosis, and an AKAP95-dependent enrichment of TPR in the spindle microtubule area in metaphase, then later in the spindle midzone area.
Report expression of connexin 43 (show GJA1 ELISA Kits) in ovarian cancer cells in G1/S phase.
The data indicate that AKAP95 is a novel nucleolus-associated protein with a regulatory role on rRNA production.
Gene dosage at 19p13.12, and AKAP8 and/or AKAP8L (show AKAP8L ELISA Kits) in particular, play an important role in modulation of head size and may contribute to autism risk.
These results suggest that AKAP8 is involved in the regulation of chromatin structural changes through nuclear tyrosine phosphorylation.
Ectopic AKAP95 stimulates expression of a chromosomal reporter gene in synergy with MLL1 or MLL2 (show MLL2 ELISA Kits), whereas AKAP95 depletion impairs retinoic acid-mediated gene induction in embryonic stem cells
AMY-1 interacts with S-AKAP84 and this protein in the cytoplasm and the nucleus, respectively, and inhibits cAMP-dependent protein kinase activity by preventing binding of its catalytic subunit to A-kinase-anchoring protein (AKAP) complex.
role of AKAP95 in DNA replication by providing a scaffold for MCM2 (show MCM2 ELISA Kits)
AKAP95 is a potential carrier protein for active caspase 3 (show CASP3 ELISA Kits) from the cytoplasm into the nuclei in apoptotic cells.
This study showed an increase in the level of global DNA methylation starting in oocytes with diameters around 60 microm, increases in histone h4, and decreases in AKAP95.
a specific role for A kinase-anchoring protein (show MYRIP ELISA Kits) 95 in suppressing the expression of the gene encoding tumor necrosis factor-alpha (show TNF ELISA Kits), which involved phosphorylation of p105 (show NEDD9 ELISA Kits) (also known as Nfkb1 (show NFKB1 ELISA Kits)) by PKA
This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins are scaffold proteins that contain a binding domain for the RI/RII subunit of protein kinase A (PKA) and recruit PKA and other signaling molecules to specific subcellular locations. This gene encodes a nuclear A-kinase anchor protein that binds to the RII alpha subunit of PKA and may play a role in chromosome condensation during mitosis by targeting PKA and the condensin complex to chromatin. A pseudogene of this gene is located on the short arm of chromosome 9.
A kinase (PRKA) anchor protein 8
, A-kinase anchor protein 8
, A-kinase anchor protein 8-like
, a-kinase anchor protein 8-like
, A-kinase anchor protein, 95kDa
, A kinase anchor protein 8
, A kinase anchor protein 95
, A-kinase anchor protein 95 kDa
, AKAP 95
, protein kinase A-anchoring protein 95