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May be required for neuronal cell differentiation.. Additionally we are shipping AHNAK Antibodies (58) and AHNAK Kits (6) and many more products for this protein.
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our results suggest that AHNAK acts as a tumor suppressor that negatively regulates TNBC cell proliferation, TNBC xenograft growth and metastasis via different signaling pathways.
AHNAK enables mammary carcinoma cells to produce and release extracellular vesicles that cause disruption of the stroma by surrounding fibroblasts
Based on the findings, the authors designate the Chlamydia trachomatis gene product corresponding to ct694-ctl0063translocated membrane-associated effector A (TmeA). Overall, the data reveal a role of TmeA during chlamydial invasion that manifests independently of effects on AHNAK.
Examination of Gene Expression Omnibus database data sets suggests that downregulation of AHNAK mRNA and mutation of the AHNAK gene are common in metastatic melanoma and correlates to a poor outcome.
inhibition of Ahnak can promote generation of induced pluripotent stem cells (iPSC) via up-regulation of endogenous c-Myc (show MYC Proteins).
tetrandrine may inhibit the growth of Hep (show EPHB6 Proteins)-2 cells by decreasing the intracellular concentration of Ca2 (show CA2 Proteins)+ and upregulating the expressions of Brg1 (show SMARCA4 Proteins) and AHNAK
Authors show here that AnxA2 (show ANXA2 Proteins), p11 (show S100A10 Proteins) and AHNAK are required for type 3 secretion system-mediated Salmonella invasion of cultured epithelial cells.
High AHNAK expression is asociated with mesothelioma.
While the structure-based consensus sequence allows interactions with various stretches of the AHNAK C-terminal domain, comparison with other S100 structures reveals that the sequence has been optimized for binding to S100A10 (show S100A10 Proteins).
The AHNAK peptide adopts a coil conformation that arches across the heterotetramer contacting both annexin A2 (show ANXA2 Proteins) and S100A10 (show S100A10 Proteins) protomers with tight affinity.
Ahnak1 plays a protective role in vascular healing after wire injuries.
Findings suggest an important role of AHNAK in the regulation of thermogenesis and lipolysis in white adipose tissue via beta-adrenergic signaling.
AHNAK plays a crucial role in body fat accumulation by regulating adipose tissue development via interaction with the SMAD1 (show SMAD1 Proteins) protein and can be involved in metabolic homeostasis
findings suggest that Ahnak might be involved in modulating the differentiation of newly generated cells into neuronal or non-neuronal cells
Results suggest that by interfering in the cross-talk between the transmembrane form of the laminin receptor dystroglycan and F-actin, AHNAK1 influences the cytoskeleton organization of Schwann cells
Ahnak mediates a negative regulation of cell growth and acts as novel tumor suppressor through potentiation of TGFB (show TGFB1 Proteins) signaling.
Ahnak protein plays an important scaffolding function connecting Erk (show EPHB2 Proteins) and Rac (show AKT1 Proteins) activation in PDGF (show PDGFA Proteins)-dependent migration of aortic smooth muscle cells (ASMC).
phosphorylation event is one mechanism underlying ahnak1's modulator function on Cav1.2 (show CACNA1C Proteins) channel activity.
these results indicate that ahnak1 is not essential for beta-adrenergic up-regulation of I (CaL (show S100A11 Proteins)) and cardiac contractility in mice.
May be required for neuronal cell differentiation.
, neuroblast differentiation-associated protein AHNAK
, AHNAK nucleoprotein
, AHNAK nucleoprotein (desmoyokin)