anti-ALK Tyrosine Kinase Receptor Antibodies
ALK encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily.
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anti-ALK Tyrosine Kinase Receptor (ALK) (AA 200-335) antibody Primary Antibody
anti-ALK Tyrosine Kinase Receptor (ALK) (AA 200-335) antibody Primary Antibody
anti-ALK Tyrosine Kinase Receptor (ALK) antibody Primary Antibody
anti-ALK Tyrosine Kinase Receptor (ALK) antibody Primary Antibody
ALK Tyrosine Kinase Receptor (ALK) Antigen Profile
Protein Summary
This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)\\/EML4 (chromosome 2), ALK\\/RANBP2 (chromosome 2), ALK\\/ATIC (chromosome 2), ALK\\/TFG (chromosome 3), ALK\\/NPM1 (chromosome 5), ALK\\/SQSTM1 (chromosome 5), ALK\\/KIF5B (chromosome 10), ALK\\/CLTC (chromosome 17), ALK\\/TPM4 (chromosome 19), and ALK\\/MSN (chromosome X).
Gene names and symbols associated with ALK
- ALK receptor tyrosine kinase (ALK) antibody
- CD246 antibody
- NBLST3 antibody
Protein level used designations for ALK
ALK tyrosine kinase receptor , CD246 antigen , mutant anaplastic lymphoma kinase
GENE ID | SPECIES |
---|---|
238 | Homo sapiens |
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