APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2) ELISA Kits

Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. Additionally we are shipping APEX2 Antibodies (60) and APEX2 Proteins (3) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
APEX2 27301 Q9UBZ4
APEX2 77622 Q68G58
Anti-Rat APEX2 APEX2 317628  
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Top APEX2 ELISA Kits at antibodies-online.com

Showing 2 out of 4 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human < 0.188 ng/mL 0.313 ng/mL - 20 ng/mL   96 Tests Log in to see 11 to 18 Days
$810.17
Details
Mouse < 0.094 ng/mL 0.156 ng/mL - 10 ng/mL   96 Tests Log in to see 11 to 18 Days
$810.17
Details

More ELISA Kits for APEX2 Interaction Partners

Human APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2) interaction partners

  1. Determinants in nuclease specificity of Ape1 (show APEX1 ELISA Kits) and Ape2, human homologues of Escherichia coli exonuclease (show EXO1 ELISA Kits) III

  2. Ape2 exhibits strong 3'-5' exonuclease and 3'-phosphodiesterase activities and has only a very weak AP-endonuclease activity.

  3. Ape2 may be involved in repair of oxidative DNA damage and PCNA (show PCNA ELISA Kits)-dependent repair synthesis.

Xenopus laevis APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2) interaction partners

  1. APE2 associates with Chk1 (show CHEK1 ELISA Kits); a serine residue (S86) in the Chk1 (show CHEK1 ELISA Kits)-binding motif of APE2 is essential for Chk1 (show CHEK1 ELISA Kits) phosphorylation, indicating a Claspin (show CLSPN ELISA Kits)-like but distinct role for APE2 in ATR-Chk1 (show CHEK1 ELISA Kits) signaling.

Mouse (Murine) APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2) interaction partners

  1. expression of Apex 2 in chondrocytes appears to be associated with the degeneration of articular cartilage in osteoarthritis.

  2. Results indicate a role for apurinic/apyrimidinic endonuclease (APE) 2 (Apex2) in the protection of germinal center (GC) cells from activation-induced cytidine deaminase (show AICDA ELISA Kits) (AID)-independent damage.

  3. data provide new insight into error-prone repair of AID-induced lesions, which we propose is facilitated by down-regulation of APE1 (show APEX1 ELISA Kits) and up-regulation of APE2 expression in germinal center B cells.

  4. Extensive analysis of bone marrow hematopoiesis in APE2-deficient mice finds inhibition of the pro-B to pre-B lymphocyte (show AKAP17A ELISA Kits) transition, due to a p53 (show TP53 ELISA Kits)-dependent DNA damage response, independent from its ubiquitous and essential homolog APE1 (show APEX1 ELISA Kits).

  5. APEX2 is required for proper cell cycle progression of proliferating lymphocytes.

  6. Both APE1 (show APEX1 ELISA Kits) and APE2 function in antibody switch recomibination, resulting in double stranded breaks necesary for this recombination.

  7. The present study clearly demonstrates that APEX2-null lymphocytes have a higher frequency of DNA breaks, indicating that APEX2 may play an important role(s) during their generation and/or repair.

  8. Apex2 is required for efficient somatic hypermutation of immunoglobulin genes.

APEX2 Antigen Profile

Antigen Summary

Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with APEX2

  • apurinic/apyrimidinic endodeoxyribonuclease 2 (APEX2) antibody
  • apurinic/apyrimidinic endodeoxyribonuclease 2 (apex2) antibody
  • APEX nuclease (apurinic/apyrimidinic endonuclease) 2 (apex2) antibody
  • apurinic/apyrimidinic endodeoxyribonuclease 2 L homeolog (apex2.L) antibody
  • APEX nuclease (apurinic/apyrimidinic endonuclease) 2 (APEX2) antibody
  • apurinic/apyrimidinic endonuclease 2 (Apex2) antibody
  • apurinic/apyrimidinic endodeoxyribonuclease 2 (Apex2) antibody
  • ape2 antibody
  • apexl2 antibody
  • C430040P13Rik antibody
  • xth2 antibody
  • zgc:55889 antibody

Protein level used designations for APEX2

AP endonuclease 2 , AP endonuclease XTH2 , DNA-(apurinic or apyrimidinic site) lyase 2 , apurinic/apyrimidinic endonuclease-like 2 , APEX nuclease 2 , apurinic-apyrimidinic endonuclease 2 , APEX nuclease (apurinic/apyrimidinic endonuclease) 2 , DNA-(apurinic or apyrimidinic site) lyase 2-like

GENE ID SPECIES
27301 Homo sapiens
448512 Xenopus (Silurana) tropicalis
393115 Danio rerio
446614 Xenopus laevis
491499 Canis lupus familiaris
511790 Bos taurus
702084 Macaca mulatta
100410557 Callithrix jacchus
100434759 Pongo abelii
77622 Mus musculus
317628 Rattus norvegicus
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