anti-ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 4 (ABCC4) Antibodies

The protein encoded by ABCC4 is a member of the superfamily of ATP-binding cassette (ABC) transporters. Additionally we are shipping ABCC4 Kits (6) and ABCC4 Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ABCC4 10257 O15439
ABCC4 239273  
ABCC4 170924  
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Top anti-ABCC4 Antibodies at

Showing 10 out of 134 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Goat Un-conjugated EIA, IF, IHC (p), WB   0.1 mg 2 to 3 Days
Human Goat Un-conjugated ELISA, IHC ABIN185302 staining (0.5µg/ml) of rat renal cortex membranes (20µg total protein per lane). Detected by western blot using chemiluminescence. Data kindly provided by Dr. Antje Steinbach, Ernst-Moritz-Arndt University of Greifswald. ABIN185302 (2.5µg/ml) staining of paraffin embedded Human Prostate. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. 100 μg 6 to 7 Days
Cow Rabbit Un-conjugated WB WB Suggested Anti-ABCC4 Antibody Titration: 1.0 ug/ml Positive Control: 721_B Whole Cell ABCC4 is supported by BioGPS gene expression data to be expressed in 721_B 100 μL 2 to 3 Days
Human Mouse Un-conjugated FACS, IHC, ELISA, WB 100 μg 11 to 16 Days
Human Rabbit Un-conjugated IHC (p), WB Anti-MRP4 Picoband antibody,  IHC(P): Rat Intestine Tissue Anti-MRP4 Picoband antibody,  IHC(P): Mouse Intestine Tissue 100 μg 4 to 6 Days
Human Rabbit Un-conjugated WB Western blot analysis of MRP4 expression in COLO320 whole cell lysates. MRP4 at 190KD was detected using rabbit anti- MRP4 Antigen Affinity purified polyclonal antibody (Catalog # ) at 0.5 µg/mL. The blot was developed using chemiluminescence (ECL) method (Catalog # EK1002). 100 μg 4 to 6 Days
Human Goat Un-conjugated ELISA, WB   100 μg 6 to 7 Days
Human Rabbit Un-conjugated EIA, WB Western blot analysis of anti-ABCC4 Antibody (C-term) in CEM cell line lysates (35ug/lane). ABCC4 (arrow) was detected using the purified Pab. 0.4 mL 6 to 8 Days
Human Goat Un-conjugated ELISA, ICC, IF, IHC, IHC (p) Human Prostate (formalin-fixed, paraffin-embedded) stained with ABCC4 antibody ABIN296628 at 2.5 ug/ml followed by biotinylated anti-goat IgG secondary antibody ABIN481715, alkaline phosphatase-streptavidin and chromogen. Anti-ABCC4 / MRP4 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. 50 μg 11 to 14 Days
Mouse Goat Un-conjugated ELISA   100 μg 6 to 7 Days

Top referenced anti-ABCC4 Antibodies

  1. Human Polyclonal ABCC4 Primary Antibody for ICC, IF - ABIN250309 : Cheng, Ren, Jackson: Multidrug resistance protein 4 mediates cAMP efflux from rat preglomerular vascular smooth muscle cells. in Clinical and experimental pharmacology & physiology 2010 (PubMed)
    Show all 8 Pubmed References

  2. Human Polyclonal ABCC4 Primary Antibody for EIA, IF - ABIN5553016 : Quan, Wang, Dong, Zhang, Wu: Characterization of chrysin glucuronidation in UGT1A1-overexpressing HeLa cells: elucidating the transporters responsible for efflux of glucuronide. in Drug metabolism and disposition: the biological fate of chemicals 2015 (PubMed)
    Show all 7 Pubmed References

  3. Human Polyclonal ABCC4 Primary Antibody for ELISA, IHC - ABIN185302 : Schuetz, Connelly, Sun, Paibir, Flynn, Srinivas, Kumar, Fridland: MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs. in Nature medicine 1999 (PubMed)
    Show all 6 Pubmed References

  4. Human Polyclonal ABCC4 Primary Antibody for IHC (p), ELISA - ABIN547358 : Hiasa, Togawa, Miyaji, Omote, Yamamoto, Moriyama: Essential role of vesicular nucleotide transporter in vesicular storage and release of nucleotides in platelets. in Physiological reports 2014 (PubMed)
    Show all 2 Pubmed References

  5. Human Monoclonal ABCC4 Primary Antibody for FACS, IHC - ABIN1724860 : Bebes, Kis, Nagy, Kurunczi, Polyánka, Bata-Csörgo, Kemény, Dobozy, Széll: The expressions of ABCC4 and ABCG2 xenobiotic transporters in human keratinocytes are proliferation-related. in Archives of dermatological research 2012 (PubMed)

  6. Human Monoclonal ABCC4 Primary Antibody for ICC, IHC (fro) - ABIN445903 : Nagy, Hollema, Andrei, Jurdzinski, Kuipers, Hoek, Tietge: The Origin of Follicular Bile Acids in the Human Ovary. in The American journal of pathology 2019 (PubMed)

More Antibodies against ABCC4 Interaction Partners

Human ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 4 (ABCC4) interaction partners

  1. release of S1P from platelets depends on MRP4; statins can interfere with this transport process

  2. Inhibition of ABCC4 potentiates combination beta agonist and glucocorticoid responses in human airway epithelial cells.

  3. miR-506 has an important role in suppressing cervical cancer cell proliferation and suppresses the expression of ABCC4 by directly targeting its 3'-UTR

  4. findings concluded that IL-13 inhibited chemotherapy sensitivity of NK/T-cell lymphoma cells by regulating ABCC4, disrupting which may effectively improve the therapy protocols against resistant NK/T-cell lymphoma.

  5. ABCC4 and (NUDT15) variants are major factors for 6-mercaptopurine intolerability in Japanese childhood acute lymphoblastic leukemia patients.

  6. Proposed is a novel full molecular model of the human MRP4, which is available to the pharmacology community to decipher the impact of any other clinically observed polymorphism and mutation on drug transport, giving rise to in silico predictive pharmacogenetics.

  7. Specific SNPs in the ABCC4 gene may increase susceptibility to Kawasaki disease in a Southern Chinese population.

  8. Data show that forkhead box protein M1 (FoxM1) enhanced carboplatin resistance in Y-79CR cells through directly up-regulating the transcription of ATP-binding cassette transporter C4 (ABCC4).

  9. MRP4 is mainly responsible for the efflux of lamivudine and entecavir in hepatocyte cultures.

  10. Data suggest that targeting the ATP binding cassette subfamily C member 4 (ABCC4)-membrane palmitoylated protein 1 (MPP1) protein complex can lead to new therapies to improve treatment outcome of acute myeloid leukemia (AML).

  11. A functional polymorphism in the ABCC4 promoter, -1508A>G, may increase extracellular 15-hydroxyeicosatetraenoic acid, sphingosine-1-phosphate, and periostin levels, contributing to airway inflammation in asthmatics.

  12. MRP4 localisation and function are regulated by interactions with SNX27, PSD95, and AP3B1.

  13. MRP4 exports prostaglandin E2 PGE2 and contributes to cell migration/metastasis in basal/triple negative breast cancer cells.

  14. This study provides direct evidence that ganciclovir (GCV) is a substrate of the efflux transporter MRP4 and suggests that the intracellular fate of GCV is significantly influenced by ABCC4 rs11568658 variant in renal transplant recipients receiving GCV

  15. Multidrug resistance protein 4 (MRP4) is a critical protein associated with the antiviral efficacy of nucleos(t)ide analogue (NA)s, and combination therapy of NA and MRP inhibitors could reduce the dosage for long-term NA use. MRP4 expression is an important factor predicting treatment failure in chronic hepatitis B patients and will provide a potential therapeutic target against hepatitis B virus.

  16. All patients with both NUDT15 rs116855232 heterozygous variants and ABCC4 rs3765534 variants suffered from severe leukopenia and required 6-mercaptopurine dose reduction to less than 35 mg/m(2)/da

  17. ABCC4 variant (rs4148500) was significantly associated with hyperuricemia and gout. The gout risk allele was associated with fractional excretion of uric acid in male individuals.

  18. ABCC4 functional SNP in the 3' splice acceptor site of exon 8 (G912T) is associated with unfavorable clinical outcome in children with acute lymphoblastic leukemia

  19. Data suggest that common SNPs in MRP4/ABCC4 (evaluated here via site-directed mutagenesis in recombinant proteins expressed in kidney cell lines) are responsible for variations in transport of methylated arsenic metabolites (major urinary arsenic metabolites in humans), prostaglandin E2, and estradiol-17 beta-glucuronide.

  20. Data indicate that R-flurbiprofen inhibits multidrug resistance-associated protein 4 (MRP4, ABCC4)-mediated prostaglandins (PG) transport.

Mouse (Murine) ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 4 (ABCC4) interaction partners

  1. The diversity at N-termini in these protein isoforms explains the diverse function of ABCC4 in mouse.

  2. ABCC4 plays a protective role against cytarabine-mediated insults in leukemic and host myeloid cells.

  3. P-gp, Bcrp, Mrp1 and Mrp4 are differentially expressed at the outer and inner blood retinal barrier, resulting in an altered ability to limit substrate distribution at the retina as compared with the blood brain barrier

  4. These findings have important clinical implications because they directly highlight an important relationship between ABCC4 transporter function and phosphodiesterases in accounting for the cAMP-directed activity of antithrombotic agents.

  5. A novel cAMP-dependent mechanism for MRP4-mediated regulation of fibroblast migration and indicated that PKA and actin play important roles as downstream effectors.

  6. Loss of MRP4 is associated with impaired platelet activation and cAMP homeostasis

  7. Upregulation of COX-2 in lung cancer promotes overexpression of MRP4 via PGE2-dependent pathway

  8. role of MRP4 in thrombus formation

  9. NHERF3 is a key regulator of organic transport in the kidney, particularly MRP4-mediated clearance of drug molecules.

  10. Abcc4 in the stomach facilitates the oral absorption of dasatinib, and it possibly plays a similar role for other orally administered substrates, such as acetylsalicylic acid.

  11. Mrp4 is not essential for the recruitment of neutrophils into the lung after LPS or CS exposure or of eosinophils after allergen exposure

  12. Data indicate that Abcc4 limits the brain penetration of camptothecin analogues and teams up with Abcb1a/b and Abcg2 to form a robust cooperative drug efflux system.

  13. Multi-drug resistance protein 4 (MRP4)-mediated regulation of fibroblast cell migration reflects a dichotomous role of intracellular cyclic nucleotides.

  14. Transport of cefadroxil by ABCC3 and ABCC4 was saturable with K(m) values of 2.5 +/- 0.7 and 0.25 +/- 0.07 mM, respectively.

  15. We have shown, for the first time, a role for MRP4 in the regulation of cAMP in cardiac myocytes and involvement of CFTR in beta-adrenergic stimulated contraction

  16. analysis of Abcc4 gene amplification in stepwise-selected mouse J774 macrophages resistant to the topoisomerase II inhibitor ciprofloxacin

  17. Mrp4 is required for normal Leydig cell testosterone production.

  18. Data show that MRP4 is the predominant isoform present at the plasma membrane of cardiacmyocytes and that it mediates the efflux of cAMP.

  19. Data show that MRP4 expression is increased in pulmonary arteries from patients with idiopathic pulmonary hypertension as well as in WT mice exposed to hypoxic conditions.

  20. FXR activation in obstructive cholestasis might worsen liver injury by hijacking a protective mechanism regulated by CAR and provides a new molecular explanation to the pathophysiology of cholestasis.

ABCC4 Antigen Profile

Protein Summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined\; however, this protein may play a role in cellular detoxification as a pump for its substrate, organic anions. Alternative splicing results in multiple splice variants encoding different isoforms.

Gene names and symbols associated with ABCC4

  • ATP binding cassette subfamily C member 4 (ABCC4) antibody
  • multidrug resistance-associated protein 4 (LOC515333) antibody
  • multidrug resistance-associated protein 4 (LOC616707) antibody
  • multidrug resistance-associated protein 4 (LOC695407) antibody
  • ATP binding cassette subfamily C member 4 (abcc4) antibody
  • ATP-binding cassette, sub-family C (CFTR/MRP), member 4 (Abcc4) antibody
  • ATP binding cassette subfamily C member 4 (Abcc4) antibody
  • D630049P08Rik antibody
  • EST170205 antibody
  • MOAT-B antibody
  • MOATB antibody
  • Mrp4 antibody

Protein level used designations for ABCC4

multidrug resistance-associated protein 4 , ATP-binding cassette, sub-family C (CFTR/MRP), member 4 , ATP-binding cassette protein C4-like , multidrug resistance-associated protein 4-like , ATP-binding cassette sub-family C member 4 , MRP/cMOAT-related ABC transporter , bA464I2.1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 4) , canalicular multispecific organic anion transporter (ABC superfamily) , multi-specific organic anion transporter B , multispecific organic anion transporter B , ABC-tranporter , ATP-binding cassette protein C4

485523 Canis lupus familiaris
515333 Bos taurus
616707 Bos taurus
695407 Macaca mulatta
100027089 Monodelphis domestica
100050431 Equus caballus
100081616 Ornithorhynchus anatinus
100391624 Callithrix jacchus
100466405 Ailuropoda melanoleuca
100491006 Xenopus (Silurana) tropicalis
10257 Homo sapiens
239273 Mus musculus
170924 Rattus norvegicus
Selected quality suppliers for anti-ABCC4 (ABCC4) Antibodies
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