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The protein encoded by ABCG8 is a member of the superfamily of ATP-binding cassette (ABC) transporters. Additionally we are shipping ABCG8 Antibodies (79) and ABCG8 Proteins (6) and many more products for this protein.
ABCG8 genetic variants may have role in the development of cholelithiasis in patients with Gaucher disease type 1.
Genetic polymorphism within the ABCG8 gene is a risk factor for diabetes.
crystallization in lipid bilayers to determine the X-ray structure of human G5G8 in a nucleotide-free state at 3.9 A resolution, generating the first atomic model of an ABC (show ABCB6 ELISA Kits) sterol transporter
A polymorphism of the sterol transporter ABCG8 has been associated with the prevalence of end-stage renal disease
Mutation in ABCG8 is associated with sitosterolaemia.
ATP-binding cassette (ABC (show ABCB6 ELISA Kits)) transporters G5 (ABCG5 (show ABCG5 ELISA Kits)) and G8 (ABCG8) form an obligate heterodimer that limits intestinal absorption and facilitates biliary secretion of cholesterol and phytosterols.
ABCG5 (show ABCG5 ELISA Kits)/8 variants are associated with susceptibility to coronary heart disease.
Sitosterolemia is caused by a genetic defect of sterolins (ABCG5 (show ABCG5 ELISA Kits)/ABCG8) mapped to the STSL (show ABCG5 ELISA Kits) locus. Polymorphic variations in STSL (show ABCG5 ELISA Kits) have been linked to lipid levels and gallstone disease
HRD1 (show SYVN1 ELISA Kits) and RMA1 may therefore be negative regulators of disease-associated transporter ABCG5 (show ABCG5 ELISA Kits)/ABCG8.
MI and gallstones, 2 seemingly unrelated diseases, are intrinsically linked via the function of the ABCG5 (show ABCG5 ELISA Kits)/8 cholesterol transporter.
ABCG5 (show ABCG5 ELISA Kits) and ABCG8 mRNA levels were significantly increased in cholesterol group and less increased in myriocin group, relative to that in normal group.
The ABCG5 (show ABCG5 ELISA Kits)/G8-independent pathway plays an important role in regulating biliary cholesterol secretion, and gallstone formation, which works independently of the ABCG5 (show ABCG5 ELISA Kits)/G8 pathway.
ABCG5 (show ABCG5 ELISA Kits)/G8 mediate mass biliary cholesterol secretion but not from a reverse cholesterol transport-relevant pool.
AdGRP78 reduced expression of lipogenic genes and plasma triglycerides in the db/db (show LEPR ELISA Kits) strain. Both G5 and G8 protein levels increased as did total biliary cholesterol
The data demonstrate that Abcg5 (show ABCG5 ELISA Kits)/Abcg8 deficiency reduces the uptake and secretion of both dietary triacylglycerols and cholesterol by the intestine, suggesting a novel role for the sterol transporter in the formation and secretion of chylomicrons.
Sitosterolemia is caused by a genetic defect of sterolins (ABCG5 (show ABCG5 ELISA Kits)/ABCG8) mapped to the STSL locus. Polymorphic variations in STSL have been linked to lipid levels and gallstone disease
The absence of an ABCG5 (show ABCG5 ELISA Kits)/ABCG8 expression.
biliary cholesterol mass secretion under maximal bile salt-stimulated conditions is fully dependent on ABCG5 (show ABCG5 ELISA Kits)/G8
This study is the first to report such toxic effects of phytosterol accumulation in ABCG5 (show ABCG5 ELISA Kits)/G8 knockout mice.
handling of sterols by the intestine involves both G5G8 and ACAT2 but that an additional factor (possibly Niemann-Pick C1-like 1) may be key in determining absorption efficiency
high expression levels of both ATP-binding cassette sub-family G member 5 (show ABCG5 ELISA Kits) and 8 (ABCG5 (show ABCG5 ELISA Kits) and ABCG8) were present in bovine liver and digestive tract samples, and in the mammary gland
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions to exclude non-cholesterol sterol entry at the intestinal level, promote excretion of cholesterol and sterols into bile, and to facilitate transport of sterols back into the intestinal lumen. It is expressed in a tissue-specific manner in the liver, intestine, and gallbladder. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG5. Mutations in this gene may contribute to sterol accumulation and atherosclerosis, and have been observed in patients with sitosterolemia.
ATP-binding cassette, sub-family G (WHITE), member 8 (sterolin 2)
, sterolin 2
, ATP-binding cassette sub-family G member 8
, ATP-binding cassette, sub-family G (WHITE), member 8
, ATP-binding cassette sub-family G member 8-like
, ATP-binding cassette, subfamily G, member 8