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The membrane-associated protein encoded by ABCA2 is a member of the superfamily of ATP-binding cassette (ABC) transporters. Additionally we are shipping ABCA2 Antibodies (78) and many more products for this protein.
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Our findings indicate a considerable and direct relationship between mRNA expression levels of ABCA2, ABCA3, MDR1, and MRP1 (show MDM4 Proteins) genes and positive minimal residual disease (MRD) measured after one year of treatment.
Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-beta production by altering Nicastrin (show NCSTN Proteins) maturation and intracellular localization.
SLC2A1/GLUT1 (show SLC2A1 Proteins), SLC1A3/EAAT1 (show SLC1A3 Proteins), and SLC1A2/EAAT2 (show SLC1A2 Proteins) were the main SLC (show CCL21 Proteins) proteins whereas ABCG2/BCRP, ABCB1/MDR1 (show ABCB4 Proteins), ABCA2 and ABCA8 (show ABCA8 Proteins) were the main ABC (show ABCB6 Proteins) quantified in isolated brain microvessels
A possible biochemical mechanism links ABCA2 expression, amyloid precursor protein (show APP Proteins) processing, and Alzheimer's disease.
we demonstrate that ABCA2-deficiency inhibits prostate tumor metastasis in vivo and decreases chemotactic potential of cells
roles for this largest known ABC (show ABCB6 Proteins) protein in neural transmembrane lipid export
Reciprocal regulation of expression of the ABCA2 promoter by the early growth response-1 (show EGR1 Proteins) and Sp-family transcription factors.
It is likely that expression of ABCA2 by two independent promoters constitutes locus of regulation controlling expression of the protein to meet requirements in different tissues.
Increased expression of ABCA2 may be causally linked with altered expression of genes associated with the pathogenesis of Alzheimer disease.
Among the 45 ABCA2 single nucleotide polymorphisms(SNPs) we tested, one synonymous SNP (rs908832) was found significantly associated with AD in both samples.
Study suggests that ABCA2 modulation of sphingolipid metabolism activates a signaling pathway that regulates amyloid precursor protein (show APP Proteins) transcription
control of ABCA2 expression level may be a key locus of regulation for esterification of plasma membrane-derived cholesterol through modulation of sphingolipid metabolism.
Data from knockout mice suggest that Abca2 functions in penile erection; Abca2 knockout mice are more susceptible to estrogen-induced convulsions than wildtype mice; Abca2 appears to be involved in biotransformation of therapeutic estrogens.
Lack of ABCA2 generates abnormalities in intracellular lipid distribution/trafficking in macrophages, increasing susceptibility to apoptosis in response to oxidized lipids and reduced atherosclerotic lesion development in LDL receptor (show LDLR Proteins) knockout mice.
The ATP-binding cassette transporter-2 (ABCA2) is a key regulator of cholesterol homeostasis and low-density lipoprotein receptor (show LDLR Proteins) metabolism in neuronal cells.
ABC-me (show ABCB10 Proteins) is a novel gene that determines the ability to tolerate cardiac ischemia/reperfusion.
ABCA2 has a role in myelin compaction in spinal cord and cerebrum, and in phenotypic tremor
ABCA2 is expressed in non-myelin-forming as well as in myelin-forming Schwann cells. ABCA2 may be involved in transport of a substance associated with cellular maturation rather than initial myelin formation in both types of Schwann cells.
ABCA2 is involved in the intracellular metabolism of sphingolipids in the brain, particularly SM and gangliosides in oligodendrocytes and certain neurons.
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is highly expressed in brain tissue and may play a role in macrophage lipid metabolism and neural development. Two transcript variants encoding different isoforms have been found for this gene.
ATP-binding cassette 2
, ATP-binding cassette sub-family A member 2
, ATP-binding cassette transporter 2
, ATP-binding cassette, sub-family A, member 2
, ATP-binding cassette, sub-family A (ABC1), member 2
, ATP-binding cassette sub-family A member 2-like
, protein smg-8 homolog
, protein smg8
, smg-8 homolog, nonsense mediated mRNA decay factor