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ATAD3A (MIM 612316) and ATAD3B are mitochondrial membrane proteins that contribute to the stabilization of large mitochondrial DNA (mtDNA)-protein complexes called nucleoids (He et al., 2007 [PubMed 17210950]).[supplied by OMIM, Sep 2008].. Additionally we are shipping ATPase Family, AAA Domain Containing 3B Antibodies (21) and ATPase Family, AAA Domain Containing 3B Proteins (4) and many more products for this protein.
ATAD3B region deletions cause cerebellar dysfunction associated with altered mitochondrial DNA and cholesterol metabolism.
exploring ATAD3 (show ATAD3A ELISA Kits) mRNA expression, we confirmed the existence of an alternative splicing in rodent and of several mRNA isoforms in human
results indicated the ATAD3B gene, which does not have ERalpha (show ESR1 ELISA Kits) binding site within 20 kb of its TSS (show RPL38 ELISA Kits), to be significantly associated with poor patient survival.
ATAD3B is a negative regulator of ATAD3A (show ATAD3A ELISA Kits) and may function as an adaptor of mitochondrial homeostasis and metabolism in human pluripotent embryonic stem cells and cancer cells.
ATAD3 (show ATAD3A ELISA Kits) may therefore be implicated in an unknown but essential and growth-linked mitochondrial function existing since pluri-cellular -organization and involved in tumorigenesis.
Results suggest that mitochondrial DNA displacement loops serve to recruit ATAD3 (show ATAD3A ELISA Kits) protein for the purpose of forming or segregating mitochondrial nucleoids.
ATAD3A (MIM 612316) and ATAD3B are mitochondrial membrane proteins that contribute to the stabilization of large mitochondrial DNA (mtDNA)-protein complexes called nucleoids (He et al., 2007
, ATPase family AAA domain-containing protein 3B