anti-ATR Interacting Protein (ATRIP) Antibodies

ATRIP encodes an essential component of the DNA damage checkpoint. Additionally we are shipping ATRIP Kits (5) and ATRIP Proteins (2) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ATRIP 84126 Q8WXE1
ATRIP 235610 Q8BMG1
ATRIP 301014  
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Top anti-ATRIP Antibodies at antibodies-online.com

Showing 10 out of 144 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Dog Mouse Un-conjugated FACS, IF, IHC, IHC (p), WB 100 μL Log in to see 11 to 14 Days
$522.50
Details
Human Rabbit Un-conjugated IC, FACS, IF, IHC, WB Immunofluorescent analysis of ATRIP staining in MCF7 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of ATRIP staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from NIH-3T3 cells, using ATRIP (Phospho-Ser68) Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from 293 cells treated with UV 15', using ATRIP (Phospho-Ser224) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human colon carcinoma, using ATRIP (Phospho-Ser224) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated ELISA, ICC, IF, IHC, WB ABIN6269383 at 1/100 staining Mouse lung tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. Western blot analysis of ATRIP expression in NIH-3T3 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated IF, IHC, ELISA, WB Western blot analysis of extracts from NIH-3T3 cells, using ATRIP (Ab-68/72) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using ATRIP (Ab-68/72) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Mouse Un-conjugated WB 100 μL Log in to see 11 to 14 Days
$507.83
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL Log in to see Available
$181.73
Details
Human Rabbit Un-conjugated ELISA, IF, IHC, WB Western Blot (WB) analysis of specific cells using ATRIP Polyclonal Antibody. 100 μL Log in to see Available
$181.73
Details
Human Rabbit Un-conjugated ELISA, IHC, WB Western blot analysis of ATRIP (Phospho-Ser224) expression in Human mammary cell lysate ABIN6268983 at 1/100 staining Mouse lung tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. 100 μL Log in to see 11 to 12 Days
$390.77
Details

Top referenced anti-ATRIP Antibodies

  1. Human Polyclonal ATRIP Primary Antibody for IP, WB - ABIN151823 : Choi, Lindsey-Boltz, Sancar: Reconstitution of a human ATR-mediated checkpoint response to damaged DNA. in Proceedings of the National Academy of Sciences of the United States of America 2007 (PubMed)

More Antibodies against ATRIP Interaction Partners

Human ATR Interacting Protein (ATRIP) interaction partners

  1. ATRIP deacetylation by SIRT2 promotes ATR-ATRIP binding to replication protein A-single-stranded DNA to drive ATR activation and thus facilitate recovery from replication stress.

  2. ATRIP SUMOylation promotes ATR activation by providing a unique type of protein glue that boosts multiple protein interactions along the ATR pathway

  3. Data on crystal structure of BRCA1 binding with phosphopeptides suggest that C-terminal domain of BRCA1 interacts with ATRIP and BAAT1 with preferences for specific side chains; in ATRIP, phospho-Ser239 and Phe242 are the main interacting residues.

  4. Data indicate that ATRIP is a direct target gene of HIF-1, and the increased ATRIP then activates the ATR signaling pathway under hypoxia.

  5. our analysis exposes an overlapping clinical manifestation between the disorders but allows an expanded spectrum of clinical features for ATR-ATRIP Seckel Syndrome to be defined

  6. as an ATR-associated kinase, Nek1 enhances the stability and activity of ATR-ATRIP before DNA damage, priming ATR-ATRIP for a robust DNA damage response

  7. ATRIP may function outside the context of the canonical ATR damage signaling pathway during HSV-1 infection to participate in the viral life cycle.

  8. data suggest that RPA-coated ssDNA is the critical structure at sites of DNA damage that recruits the ATR-ATRIP complex and facilitates its recognition of substrates for phosphorylation and the initiation of checkpoint signaling

  9. there are at least two in vitro ATR-ATRIP DNA binding complexes, one which binds DNA with high affinity in an RPA-dependent manner and a second, which binds DNA with lower affinity in an RPA-independent manner

  10. Collectively, our results suggest that the ATR-mediated phosphorylation of ATRIP at Ser-68 and -72 is dispensable for the initial response to DNA damage.

  11. N-terminal domain of the ATRIP protein contributes to the cell cycle checkpoint by regulating the intranuclear localization of ATR

  12. ATRIP is required for ATR accumulation at intranuclear foci induced by DNA damage.

  13. ATRIP oligomerization is essential for the function of the ATM and Rad3-related (ATR)-ATRIP complex, which exists in higher order oligomeric states within cells

  14. The expression of dimerization-defective ATRIP diminishes the maintenance of replication forks during treatment with DNA replication inhibitors.

  15. support the idea of a multistep model for ATR activation that requires separable localization and activation functions of ATRIP

  16. a direct physical interaction between BRCA1 and ATRIP is required for the checkpoint function of ATR

  17. ATRIP is a CDK2 substrate, and CDK2-dependent phosphorylation of S224 regulates the ability of ATR-ATRIP to promote cell cycle arrest in response to DNA damage

Xenopus laevis ATR Interacting Protein (ATRIP) interaction partners

  1. ATRIP must associate with ATR in order for ATR to carry out the phosphorylation of Chk1 effectively

  2. Data show that recombinant TopBP1 induces a large increase in the kinase activity of both Xenopus and human ATR-ATRIP.

ATRIP Antigen Profile

Protein Summary

This gene encodes an essential component of the DNA damage checkpoint. The encoded protein binds to single-stranded DNA coated with replication protein A. The protein also interacts with the ataxia telangiectasia and Rad3 related protein kinase, resulting in its accumulation at intranuclear foci induced by DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with ATRIP

  • ATR interacting protein (ATRIP) antibody
  • ATR interacting protein (Atrip) antibody
  • ATR interacting protein S homeolog (atrip.S) antibody
  • ATR interacting protein (atrip) antibody
  • mutagen-sensitive 304 (mus304) antibody
  • ATRIP, ATR checkpoint kinase regulatory subunit Rad26 (rad26) antibody
  • 6620401K05Rik antibody
  • anon-WO0140519.82 antibody
  • atrip antibody
  • CG7347 antibody
  • Dmel\\CG7347 antibody
  • mus(3)304 antibody
  • mus-304 antibody
  • Mus304 antibody
  • si:dkey-42i9.5 antibody
  • trex1 antibody
  • Xatrip antibody

Protein level used designations for ATRIP

ATM and Rad3-related-interacting protein , ATR-interacting protein , ATM and Rad3 related interacting protein , three prime repair exonuclease 1 , ATR interacting protein , ATR-interacting protein-like , CG7347-PA , mus304-PA , mutagen sensitive 304 , ATRIP

GENE ID SPECIES
84126 Homo sapiens
235610 Mus musculus
301014 Rattus norvegicus
415949 Gallus gallus
496388 Xenopus laevis
558534 Danio rerio
608504 Canis lupus familiaris
742205 Pan troglodytes
100063799 Equus caballus
100101245 Xenopus (Silurana) tropicalis
100125287 Bos taurus
100355293 Oryctolagus cuniculus
100411124 Callithrix jacchus
100453171 Pongo abelii
40003 Drosophila melanogaster
2543289 Schizosaccharomyces pombe 972h-
100023426 Monodelphis domestica
100476250 Ailuropoda melanoleuca
100523399 Sus scrofa
100590808 Nomascus leucogenys
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