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Transcriptional regulator. Additionally we are shipping and many more products for this protein.
Showing 10 out of 12 products:
dlx1a/2a act downstream of ascl1a but upstream of dlx5a/dlx6a and gad1b to activate GABAergic specification
bHLH transcription factor (show MSGN1 Antibodies) Ascl1a is essential for the specification of the intestinal secretory cells and mediates Notch (show NOTCH1 Antibodies) signaling in the zebrafish intestine
Loss of ascl1a prevents secretory cell differentiation within the zebrafish intestinal epithelium resulting in a loss of distal intestinal motility
Data show that injury-dependent induction of Ascl1a suppressed expression of the Wnt (show WNT2 Antibodies) signaling inhibitor, Dkk (show DKK1 Antibodies), and induced expression of the Wnt (show WNT2 Antibodies) ligand, Wnt4a.
The Ascl1a regulates Muller glia dedifferentiation and retinal regeneration through a Lin-28 (show LIN28A Antibodies)-dependent, let-7 microRNA signalling pathway.
ash1a and ngn1 (show NEUROG1 Antibodies) function in parallel redundant pathways to regulate neurogenesis downstream of flh (show NOTO Antibodies)
Ascl1a might act downstream of diencephalic fibroblast growth factor 3 (Fgf3 (show FGF3 Antibodies)) signaling to mediate some of the effects of Fgf3 (show FGF3 Antibodies) on the developing adenohypophysis
ascl1a is essential for retina regeneration: within 4 h after retinal injury, ascl1a is induced in Muller glia.
Transcriptional regulator. May mediate transcription activation by binding to the E box-containing promoter (By similarity). Involved in neurogenesis. Required for the development of neurons in the epiphysis, acting partially redundantly with neurog1 and downstream of flh. Involved in maintaining rhombomere boundaries in the hindbrain, probably via up-regulation of delta expression. Also involved in pituitary development\; required cell-autonomously in adenohypophyseal cells for endocrine differentiation and for survival of a subset of cells.
achaete-scute homolog 1a
, pituitary absent
, pituitary-absent protein