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ALCAM encodes activated leukocyte cell adhesion molecule (ALCAM), also known as CD166 (cluster of differentiation 166), which is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like domains (VVC2C2C2) in the extracellular domain. Additionally we are shipping CD166 Antibodies (306) and CD166 Proteins (41) and many more products for this protein.
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Human CD166 ELISA Kit for Sandwich ELISA - ABIN414348
Al-Shehri, Abd El Azeem: Activated Leukocyte Cell Adhesion Molecule (ALCAM) in Saudi Breast Cancer Patients as Prognostic and Predictive Indicator. in Breast cancer : basic and clinical research 2015
Alcama mediates Edn1 (show EDN1 ELISA Kits) signaling during zebrafish cartilage morphogenesis.
The cell-adhesion molecule (show MCAM ELISA Kits) Alcam is required for proper nephrogenesis and functions downstream of Fzd3 (show FZD3 ELISA Kits) during embryonic kidney development.
No significant association between ALCAM expression and survival data was observed for all tumors
These data indicate that cardiac surgery influences the expression of CD162 (show SELPLG ELISA Kits), CD166 and CD195 and that the intensity of the immune system response, displayed as the change in the CD162 (show SELPLG ELISA Kits), CD166, CD195 expression, varies, depending on the surgical technique used.
These findings indicate that high ALCAM expression is associated with poor prognosis and advanced clinicopathological characteristics in CRC (show CALR ELISA Kits) patients.
ALCAM is a potential mediator in the late complications of diabetes in the kidney.
we show that although the histological detection of ALCAM within the tumor tissue correlates strongly with tumor stage in BCa (show BLNK ELISA Kits) (Figure (Figure2),2), it does not appear to be prognostic of overall survival. In contrast, urine ALCAM correlates with tumor stage and is a significant independent predictor of 3-year overall survival for patients after cystectomy.
Our data indicate that Gal-8 interacts with ALCAM at the surface of breast cancer cells through glycosylation-dependent mechanisms. A novel heterophilic interaction between ALCAM and Gal-8 is demonstrated here, suggesting its physiologic relevance in the biology of breast cancer cells
CD166 functions as a risk factor for cancers, and the alterations of its different functional isoforms were observed to correlate with specific or interplayed clinical outcomes.
The results highlight the potential of ALCAM as a recurrent biomarker in early-stage endometrioid endometrial cancer and point to ALCAM as an important molecule in endometrial cancer dissemination by regulating cell migration, invasion, and metastasis.
MiR (show MLXIP ELISA Kits)-148a and miR (show MLXIP ELISA Kits)-152 can sensitize tamoxifen-resistant MCF-7 breast cancer cells to tamoxifen via downregulating ALCAM.
CHIP directly regulates the stability of CD166 protein through the ubiquitin proteasome system.
ALCAM is overexpressed on the surface of Human T-lymphotropic virus type 1-infected lymphocytes, both in chronically infected cell lines and in primary infected CD4 (show CD4 ELISA Kits)(+) T lymphocytes.
Our data demonstrate that ALCAM KO mice develop a more severe active experimental autoimmune encephalomyelitis, which can be explained by an increased permeability of their BBB (show ALMS1 ELISA Kits). This loss in BBB (show ALMS1 ELISA Kits) integrity is due to a dysregulation of junctional molecules caused by the lack of ALCAM at the level of the TJ molecules.
demonstrates for the first time the in vivo contribution of ALCAM to angiogenesis and reveals a novel role of stromally expressed ALCAM in supporting tumor growth and metastatic spread
Our results indicate that the loss of CD166 impacts hematopoietic stem cell numbers
Data indicate that the CD166/AKT (show AKT1 ELISA Kits) axis modulates tumorigenesis via promotion of phosphorylation and facilitation of degradation, ubiquitination and cytosolic accumulation of FOXO (show FOXO3 ELISA Kits) proteins in liver cancer cells.
ALCAM stably interacts with actin by binding to syntenin-1 (show SDCBP ELISA Kits) and ezrin (show EZR ELISA Kits).
CD166/ALCAM (ALCAM) is a close structural and functional homolog of RAGE (show AGER ELISA Kits); it shows that binding of S100B (show S100B ELISA Kits) to CD166/ALCAM induces dose- and time-dependent expression of NF-kappaB (show NFKB1 ELISA Kits) family members in wild type and RAGE (show AGER ELISA Kits)-deficient mouse endothelial cells.
Activated Leukocyte Cell Adhesion Molecule (ALCAM) or CD166 expression on osteoblasts is directly correlated with Runx2 (show RUNX2 ELISA Kits) expression and high hematopoiesis enhancing activity.
Behavioral deficits caused by prolonged IFN alpha (show IFNA ELISA Kits) treatment were not prevented by blocking ALCAM, which is involved in immune cell entry to the brain.
novel role for ALCAM in stabilizing LEC-LEC interactions and in the organization and function of the LV network.
The presence of CD166 on prostate stem/progenitors and castration resistant sub-populations suggest that it is a cell surface molecule with the potential for targeted delivery of human prostate cancer therapeutics.
ALCAM up-regulation by hypercholesterolemia suggests a side-specific spatial role in the recruitment of leukocytes to aortic valve sclerosis sites.
This gene encodes activated leukocyte cell adhesion molecule (ALCAM), also known as CD166 (cluster of differentiation 166), which is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like domains (VVC2C2C2) in the extracellular domain. This protein binds to T-cell differentiation antigene CD6, and is implicated in the processes of cell adhesion and migration. Multiple alternatively spliced transcript variants encoding different isoforms have been found.
CD166 antigen homolog A
, DM-GRASP homolog
, zn5 / zn-5 antigen
, zn8 / zn-8 antigen
, activated leukocyte cell adhesion molecule
, CD166 antigen
, DM-GRASP II
, CD166 antigen-like
, CD166 antigen homolog
, SB-10 antigen
, activated leucocyte cell adhesion molecule
, BEN glycoprotein
, SC1 glycoprotein