Adaptor-Related Protein Complex 3, beta 1 Subunit (AP3B1) ELISA Kits

AP3B1 encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. Additionally we are shipping AP3B1 Antibodies (46) and AP3B1 Proteins (3) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
AP3B1 8546 O00203
Anti-Mouse AP3B1 AP3B1 11774 Q9Z1T1
Anti-Rat AP3B1 AP3B1 309969  
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Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 0.064 ng/mL 0.15 ng/mL - 10 ng/mL   96 Tests Log in to see 13 to 16 Days
$736.84
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More ELISA Kits for AP3B1 Interaction Partners

Human Adaptor-Related Protein Complex 3, beta 1 Subunit (AP3B1) interaction partners

  1. point mutation c.2702C>G in exon 23 of the AP3B1 gene caused deletion of 112 bp in the mRNA in two siblings. This mutation activates a cryptic donor splice site that overrules the wild-type donor splice site of this exon. Three other novel mutations in AP3B1 were identified, that is, a nonsense mutation c.716G>A (p.Trp239Ter), a 1-bp and a 4-bp deletion c.177delA and c.1839_1842delTAGA, respectively

  2. Synergistic defects of UNC13D and AP3B1 leading to adult hemophagocytic lymphohistiocytosis.

  3. Using a co-affinity purification strategy, authors have identified the beta subunit of the AP-3 adapter protein complex, AP3B1, as a binding partner for the M proteins of the zoonotic paramyxoviruses Nipah virus and Hendra virus.

  4. Data indicate that RUN and FYVE domain protein Rabip4'(RUFY1) interacts specifically and directly with adaptor protein complex AP-3.

  5. The study provides a description of two unrelated individuals with Hermansky Pudlak syndrome type 2 associated with novel mutations in AP3B1.

  6. diphosphoinositol pentakisphosphate-mediated pyrophosphorylation of AP3B1 modulates the interaction with Kif3A and, as a consequence, affects the release of HIV-1 virus-like particles.

  7. Two nonsense mutations in ADTB3A, C1578T (R-->X) and G2028T (E-->X), result in lack of ADTB3A mRNA and beta3A protein production and a severe, G-CSF-responsive neutropenia in addition to oculocutaneous albinism and platelet storage pool deficiency.

  8. Description of mutations in HPS genes that cause Hermansky-Pudlak syndrome (review)

  9. We defined a homozygous genomic deletion in AP3B1, the gene encoding the beta chain of the adaptor protein-3 (AP-3) complex. The mutation leads to in-frame skipping of exon 15 and thus perturbs proper assembly of the heterotetrameric AP-3 complex.

  10. A novel homozygous mutation in AP3B1 was detected in a 2-year-old patient with oculocutaneous albinism and immunodeficiency with Hermansky-Pudlak syndrome type II and eventual acute fatal hemophagocytic lymphohistiocytosis.

  11. Mutations in AP3B1 is not associated with familial hemophagocytic lymphohistiocytosis

  12. AP-1 and AP-3 are involved in the formation of distinct types of clathrin-coated vesicles, each of which is characterized by the incorporation of specific cargo membrane proteins

  13. Experimental investigation of five specific genes, AP3B1, ATP6AP1, BLOC1S1, LAMP2, and RAB11A, has confirmed novel roles for these proteins in the proper initiation of macroautophagy in amino acid-starved fibroblasts.

Mouse (Murine) Adaptor-Related Protein Complex 3, beta 1 Subunit (AP3B1) interaction partners

  1. HIV-2 particle release was dependent on the adaptor protein complex AP-3 and the newly identified AP-5 complex, but much less so on AP-1.

  2. Data show that cytokine activation as a result of toll-like receptor 2 (TLR2) stimulation occurs at different intracellular locations and is mediated by the phagosomal trafficking molecule adaptor protein-3 (AP-3).

  3. has a minimal impact on protective anti-cytomegalovirus responses

  4. Our study indicates that Ap3b1 gene play distinct roles in melanin production and tyrosinase distribution compared with Hps1 gene.

  5. we show that loss of the related adaptor protein AP-1 has a similar effect on regulated secretion but exacerbates the effect of AP-3 RNAi, suggesting distinct roles for the two adaptors in the regulated secretory pathway.

  6. Data suggest functional links between OCA2 and the BLOC-1, BLOC-2, and AP-3 protein complexes involved in melanosome biogenesis.

  7. The identification of the feeble mutation led to our subsequent observations that AP-3, as well as the BLOC-1 and BLOC-2 are essential for plasmacytoid dendritic cells signaling through TLR7 and TLR9.

  8. TLR9 signals leading to activation of IFN I, require TLR9 trafficking from endosomes to lysosome-related organelle; adapter protein-3 identified as protein complex responsible for trafficking of TLR9 to this subcellular compartment

  9. AP-3 mediates the intracellular trafficking of CD1d to lysosomes for sampling of lipid antigens (Ags) involved in self-Ag presentation and thymocyte-positive selection.

  10. AP-3 requirement is a particular attribute of the CD1d pathway in mice and that, although MHC class II molecules and CD1d are both found in late endosomes or lysosomes, different pathways mediate their intracellular trafficking

  11. AP-3B plays a critical role in the normal formation and function of a subset of synaptic vesicles

  12. the functions of beta3A- and beta3B-containing complexes are distinct and divergent in brain

  13. AP-1 and AP-3 are involved in the formation of distinct types of clathrin-coated vesicles, each of which is characterized by the incorporation of specific cargo membrane proteins

  14. WNK4 inhibits NCC activity by diverting the cotransporter to the lysosome for degradation by way of an AP-3 transport carrier

AP3B1 Antigen Profile

Antigen Summary

This gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. The encoded protein is part of the heterotetrameric AP-3 protein complex which interacts with the scaffolding protein clathrin. Mutations in this gene are associated with Hermansky-Pudlak syndrome type 2. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with AP3B1

  • adaptor related protein complex 3 beta 1 subunit L homeolog (ap3b1.L) antibody
  • adaptor-related protein complex 3, beta 1 subunit a (ap3b1a) antibody
  • adaptor related protein complex 3 beta 1 subunit (AP3B1) antibody
  • adaptor-related protein complex 3, beta 1 subunit (Ap3b1) antibody
  • ADTB3 antibody
  • ADTB3A antibody
  • AP-3 antibody
  • AP3B1 antibody
  • AU015684 antibody
  • beta3A antibody
  • C78395 antibody
  • cb964 antibody
  • HPS antibody
  • Hps2 antibody
  • pe antibody
  • pearl antibody
  • rim2 antibody

Protein level used designations for AP3B1

adaptor-related protein complex 3, beta 1 subunit , AP-3 complex subunit beta-1 , adaptor-related protein complex 3, beta-1 subunit , AP-3 complex subunit beta-1-like , AP-3 complex beta-3A subunit , adaptor protein complex AP-3 subunit beta-1 , beta-3A-adaptin , clathrin assembly protein complex 3 beta-1 large chain , adapter-related protein complex 3 subunit beta-1 , adaptor protein complex AP-3 beta-1 subunit , adaptor-related protein complex AP-3, beta 1 subunit , beta3A-adaptin , recombination induced mutation 2 , adaptor-related protein complex AP3 beta 1 subunit

GENE ID SPECIES
443724 Xenopus laevis
386770 Danio rerio
427646 Gallus gallus
461789 Pan troglodytes
100019944 Monodelphis domestica
100049670 Sus scrofa
100065436 Equus caballus
100226392 Taeniopygia guttata
100350054 Oryctolagus cuniculus
100397094 Callithrix jacchus
100584809 Nomascus leucogenys
708754 Macaca mulatta
8546 Homo sapiens
11774 Mus musculus
309969 Rattus norvegicus
767602 Bos taurus
403459 Canis lupus familiaris
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