anti-Adenosylhomocysteinase-Like 1 (AHCYL1) Antibodies

The protein encoded by AHCYL1 interacts with inositol 1,4,5-trisphosphate receptor, type 1 and may be involved in the conversion of S-adenosyl-L-homocysteine to L-homocysteine and adenosine. Additionally we are shipping AHCYL1 Proteins (5) and AHCYL1 Kits (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
AHCYL1 10768 O43865
AHCYL1 362013  
AHCYL1 229709 Q80SW1
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Top anti-AHCYL1 Antibodies at antibodies-online.com

Showing 10 out of 40 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB Host: Rabbit Target Name: AHCYL1 Sample Type: Human Fetal Liver Antibody Dilution: 1.0ug/ml Host: Rabbit Target Name: AHCYL1 Sample Type: Human Fetal Lung Antibody Dilution: 1.0ug/ml 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-AHCYL1 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:1562500  Positive Control:  Human Placenta 100 μL Log in to see 2 to 3 Days
$319.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Western Blot: AHCYL1 Antibody [NBP1-83093] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10.Lane 2: Human cell line RT-4.Lane 3: Human cell line U-251MG sp Immunocytochemistry/Immunofluorescence: AHCYL1 Antibody [NBP1-83093] - Staining of human cell line A-431 shows positivity in cytoplasm. 0.1 mL Log in to see 10 to 13 Days
$494.38
Details
Human Rabbit Un-conjugated IHC, WB Western blot analysis of extracts from rat spleen, using AHCYL1 antibody. Lane 1 was treated with the blocking peptide. ABIN6272935 at 1/100 staining Mouse colon tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Mouse Un-conjugated IHC (p), ELISA, WB AHCYL1 monoclonal antibody (M05), clone 5D6 Western Blot analysis of AHCYL1 expression in HeLa . Immunoperoxidase of monoclonal antibody to AHCYL1 on formalin-fixed paraffin-embedded human stomach. [antibody concentration 3 ug/ml] 100 μg Log in to see 11 to 12 Days
$440.00
Details
Human Mouse Un-conjugated ELISA, WB AHCYL1 monoclonal antibody (M03), clone 1B3. Western Blot analysis of AHCYL1 expression in HeLa . AHCYL1 monoclonal antibody (M03), clone 1B3. Western Blot analysis of AHCYL1 expression in PC-12 . 100 μg Log in to see 11 to 12 Days
$440.00
Details
Human Rabbit Un-conjugated IHC, WB Western blot analysis of extracts of various cell lines, using AHCYL1 antibody. Immunohistochemistry of paraffin-embedded human stomach using AHCYL1 antibody at dilution of 1:100 (x40 lens). 100 μL Log in to see 11 to 13 Days
$366.77
Details
Human Rabbit Un-conjugated IHC, ELISA, WB 100 μL Log in to see 11 to 14 Days
$419.83
Details
Chicken Rabbit Un-conjugated WB   50 μg Log in to see 4 to 8 Days
$462.00
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL Log in to see 2 to 3 Days
$446.88
Details

Top referenced anti-AHCYL1 Antibodies

  1. Human Polyclonal AHCYL1 Primary Antibody for ELISA, WB - ABIN564694 : Yamaguchi, Ishikawa: IRBIT reduces the apparent affinity for intracellular Mg²? in inhibition of the electrogenic Na?-HCO?? cotransporter NBCe1-B. in Biochemical and biophysical research communications 2012 (PubMed)

  2. Human Monoclonal AHCYL1 Primary Antibody for IHC (p), ELISA - ABIN564695 : Scicchitano, Dalmas, Boyce, Thomas, Frazier: Protein extraction of formalin-fixed, paraffin-embedded tissue enables robust proteomic profiles by mass spectrometry. in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2009 (PubMed)

More Antibodies against AHCYL1 Interaction Partners

Human Adenosylhomocysteinase-Like 1 (AHCYL1) interaction partners

  1. We investigated previously assumed interaction with AHCY-like-1 protein (AHCYL1), a paralog of AHCY. Indeed, significant interaction between both proteins exists. Additionally, silencing AHCYL1 leads to moderate inhibition of nuclear export of endogenous AHCY.

  2. We have validated the vectors and confirmed self-association of AHCY, AHCYL1, and galectin-3. In a high-throughput BiFC screen, we identified new AHCY interaction partners: galectin-3 and PUS7L. We also describe additional steps in protein interaction analysis, applied for AHCY-galectin-3 interaction

  3. These results suggest that by inhibiting Bcl2l10 activity and promoting contact between endoplasmic reticulum and mitochondria, IRBIT facilitates massive Ca(2+) transfer to mitochondria and promotes apoptosis.

  4. IRBIT forms signaling complexes with PIPKIalpha and NBCe1-B, whose activity is regulated by PI(4,5)P2.

  5. Formation of the Ribonucleotide reductase-IRBIT complex is regulated through phosphorylation of IRBIT, and ablation of IRBIT expression in HeLa cells causes imbalanced dNTP pools and altered cell cycle progression.

  6. IRBIT is a master regulator of ion channels and ion transporters. (Review)

  7. IRBIT plays an important role in intracellular pH regulation, mediated by NHE3, and further regulated by SPAK.

  8. relationships between the WNK/SPAK and IRBIT/PP1 sites in the regulation of Na+-HCO3- cotransporters

  9. conclude that AHCYL1 expression is associated with ovarian carcinogenesis as an oncogene in chickens, whereas it plays the role of tumor suppressor in human EOC, suggesting a paradoxical function of AHCYL1 in ovarian carcinogenesis

  10. A NBCe1-B construct that lacks amino acid residues 2-16 of the amino-terminus is fully autoinhibited, but cannot be stimulated by IRBIT, indicating that autoinhibitory and IRBIT-binding determinants within the cytosolic amino-terminus are not identical.

  11. Both IRBIT (inositol 1,4,5-trisphosphate receptor-binding protein) and WNK [with no lysine (K)] kinase have been implicated as additional HCO(3)(-) secretory controllers.

  12. IRBIT opposes the effects of WNKs and SPAK by recruiting PP1 to the complex to dephosphorylate CFTR and NBCe1-B, restoring their cell surface expression, in addition to stimulating their activities

  13. IRBIT is critically involved in mediating activation of NHE3 by ANG II via a Ca(2+)/calmodulin-dependent protein kinases II-dependent pathway.

  14. regulation through IRBIT enables NBC1 variants to have different physiological roles

  15. An IRBIT homologue, Long-IRBIT, demonstrates only weak binding ability to inositol 1,4,5-trisphosphate receptor because of an inhibitory effect of its LISN domain, a Long-IRBIT specific N-terminal appendage.

Zebrafish Adenosylhomocysteinase-Like 1 (AHCYL1) interaction partners

  1. AHCYL1 has a different function from AHCY and plays an important role in embryogenesis by modulating inositol 1,4,5-trisphosphate receptor function for the intracellular calcium release

Mouse (Murine) Adenosylhomocysteinase-Like 1 (AHCYL1) interaction partners

  1. NHERF1 mediates ANG II-induced activation of renal NHE3, which requires coordination between IRBIT and the NHERF1 PDZ1 domain in binding and transporting NHE3

  2. IRBIT forms signaling complexes with PIPKIalpha and NBCe1-B, whose activity is regulated by PI(4,5)P2.

  3. IRBIT suppresses CaMKIIalpha activity and contributes to catecholamine homeostasis through TH phosphorylation.

  4. Irbit was sequestered by InsP3 receptors (IP3Rs) in the endoplasmic reticulum

  5. IRBIT opposes the effects of WNKs and SPAK by recruiting PP1 to the complex to dephosphorylate CFTR and NBCe1-B, restoring their cell surface expression, in addition to stimulating their activities

  6. IRBIT can directly interact with the IP3R, and that both the suppressor domain and the IP3-binding core of the IP3R are essential for a strong interaction.

  7. phosphorylation of Ser71 and Ser74 were sufficient to enable inhibition of IP3 binding to the IP3R by IRBIT

  8. Cloning, bacterial expression, and unique structure of adenosylhomocysteine hydrolase-like protein 1, or inositol 1,4,5-triphosphate receptor-binding protein.

  9. Data show that pNBC1 activation requires the IRBIT PEST domain, while CFTR activation requires multiple domains, and suggest that IRBIT is a key coordinator of epithelial fluid and HCO3- secretion.

  10. Results sugest that IRBIT modulates the polyadenylation state of specific mRNAs, both by controlling the cytoplasmic/nuclear partitioning of Fip1 and by inhibiting PAP activity, in response to a stimulus that alters its phosphorylation state.

AHCYL1 Antigen Profile

Protein Summary

The protein encoded by this gene interacts with inositol 1,4,5-trisphosphate receptor, type 1 and may be involved in the conversion of S-adenosyl-L-homocysteine to L-homocysteine and adenosine. Several transcript variants encoding two different isoforms have been found for this gene.

Gene names and symbols associated with AHCYL1

  • adenosylhomocysteinase like 1 (AHCYL1) antibody
  • adenosylhomocysteinase like 1 (ahcyl1) antibody
  • adenosylhomocysteinase like 1 S homeolog (ahcyl1.S) antibody
  • adenosylhomocysteinase-like 1 (Ahcyl1) antibody
  • adenosylhomocysteinase-like 1 (ahcyl1) antibody
  • S-adenosylhomocysteine hydrolase-like 1 (Ahcyl1) antibody
  • 1110034F20Rik antibody
  • AA409031 antibody
  • AA414901 antibody
  • Ahcy-rs3 antibody
  • cb586 antibody
  • DCAL antibody
  • Irbit antibody
  • PRO0233 antibody
  • wu:fj66f02 antibody
  • XPVKONA antibody

Protein level used designations for AHCYL1

adenosylhomocysteinase-like 1 , putative adenosylhomocysteinase 2-like , S-adenosylhomocysteine hydrolase-like 1 , putative adenosylhomocysteinase 2 , DC-expressed AHCY-like molecule , S-adenosyl homocysteine hydrolase homolog , S-adenosyl-L-homocysteine hydrolase 2 , S-adenosylhomocysteine hydrolase-like protein 1 , adoHcyase 2 , dendritic cell expressed AHCY-like protein , inositol 1,4,5-trisphosphate receptor-binding protein , IP3R binding protein released with inositol 1,4,5-trisphosphate , IP3R-binding protein released with inositol 1,4,5-trisphosphate , S-adenosylhomocysteine hydrolase, related sequence 3

GENE ID SPECIES
100033080 Monodelphis domestica
100073556 Ornithorhynchus anatinus
100158541 Xenopus (Silurana) tropicalis
100407815 Callithrix jacchus
100451773 Pongo abelii
100590420 Nomascus leucogenys
447640 Xenopus laevis
419803 Gallus gallus
10768 Homo sapiens
611790 Canis lupus familiaris
505511 Bos taurus
362013 Rattus norvegicus
798918 Danio rerio
229709 Mus musculus
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