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AGPS is a member of the FAD-binding oxidoreductase/transferase type 4 family. Additionally we are shipping AGPS Kits (6) and AGPS Proteins (4) and many more products for this protein.
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we optimized the BITC construction targeting alkylglycerone phosphate synthase (AGPS) by computer-aided design, and the derivants also showed anti-tumor potential in vitro.
AGPS overexpression could be a causation of chemotherapy agent resistance of cancer cells. AGPS silencing could lead to drug uptake and cell cycle arrest and apoptotic cell death.
Results demonstrated that AGPS negatively regulated the invasion potential of glioma and hepatic carcinoma cells by modulating the expression of relevant genes and activity of the MAPK (show MAPK1 Antibodies) pathway.
AGPS, in addition to maintaining ether lipids, also controls cellular utilization of fatty acids, favoring the generation of signaling lipids necessary for promoting the aggressive features of cancer.
Novel mutations in AGPS (alkylglycerone-phosphate synthase) cause rhizomelic chondrodysplasia (show COL11A1 Antibodies) punctata (RCDP) type 3.
Defect of ADAPS expression was also assessed by immunoblot
Linkage analysis mapped the bs2 locus to mouse chromosome 2
This gene is a member of the FAD-binding oxidoreductase/transferase type 4 family. It encodes a protein that catalyzes the second step of ether lipid biosynthesis in which acyl-dihydroxyacetonephosphate (DHAP) is converted to alkyl-DHAP by the addition of a long chain alcohol and the removal of a long-chain acid anion. The protein is localized to the inner aspect of the peroxisomal membrane and requires FAD as a cofactor. Mutations in this gene have been associated with rhizomelic chondrodysplasia punctata, type 3 and Zellweger syndrome.
alkyldihydroxyacetonephosphate synthase, peroxisomal
, alkylglycerone phosphate synthase
, alkyldihydroxyacetone phosphate synthase
, alkyldihydroxyacetonephosphate synthase, peroxisomal-like
, aging-associated gene 5 protein
, aging-associated protein 5
, alkyl-DHAP synthase
, alkylglycerone-phosphate synthase
, alkyl-dihydroxyacetonephosphate synthase
, alkylglycerone phosphate synthase-like