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ACCN2 encodes a member of the acid-sensing ion channel (ASIC) family of proteins, which are part of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. Additionally we are shipping Amiloride-Sensitive Cation Channel 2, Neuronal Proteins (7) and and many more products for this protein.
Showing 10 out of 149 products:
Mammalian Monoclonal ACCN2 Primary Antibody for ISt, IHC - ABIN1304544
Lin, Sun, Chen: Genetic exploration of the role of acid-sensing ion channels. in Neuropharmacology 2015
Show all 3 Pubmed References
Mouse (Murine) Polyclonal ACCN2 Primary Antibody for ELISA, WB - ABIN4277576
Hoagland, Sherwood, Lee, Walker, Askwith: Identification of a calcium permeable human acid-sensing ion channel 1 transcript variant. in The Journal of biological chemistry 2010
Study shows that bile acids potentiate proton-activated currents in Xenopus laevis oocytes expressing human acid-sensing ion channel. Site-directed mutagenesis demonstrated that the amino acid residue G433 is critically involved in the potentiating effect of bile acids on ASIC1a activation by protons.
Genetic variants in the ACCN2 are associated with differential sensitivity to CO2.
The deactivation of ASIC1 was steeply dependent on the pH, spanning nearly three orders of magnitude from extremely fast at pH 8 to very slow at pH 7.
Results show that the "acidic pocket," the binding site of several toxins, is not essential for channel function but has, rather, a modulatory role. Furthermore, the study describes the structural rearrangements occurring in this domain during ASIC activity, and highlight the importance of the "palm" domain in channel opening and current decay.
our results suggest that ASIC1a is critical for liver cancer cell proliferation and its deregulation is frequently linked to liver cancer
the data demonstrate a functional link between ASICs and [Ca(2 (show CA2 Antibodies)+)]i/RhoA (show RHOA Antibodies) pathway, which contributes to the acidity-induced epithelial-mesenchymal transition.
ASIC1 contributes to breast cancer pathogenesis in response to acidic tumor microenvironments
The results show that acid-sensing ion channel 1, acid-sensing ion channel 2 (show ACCN1 Antibodies), and acid-sensing ion channel 3 (show ACCN3 Antibodies) are expressed in A549 cells at the messenger RNA and protein levels, and acid-sensing ion channel-like currents were elicited by extracellular acid stimuli.
Data show that acid sensing ion channel 1a (ASIC1a) mediated calcium influx, which resulted in the activation of PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) signaling and increased drug resistance, suggesting that ASIC1a/Ca(2 (show CA2 Antibodies)+)/PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) signaling represents a pathway that regulates drug resistance, thus offering a potential target for chemotherapy of hepatocellular carcinoma (HCC (show FAM126A Antibodies)).
Downregulation of ASIC1 inhibits gastric cancer growth via decreasing autophagy, therefore this strongly suggests a therapeutic role for ASIC1 in gastric cancer.
These data demonstrate the involvement of an ASIC1a-mediated insular synaptic depression mechanism in extinction learning.
ASIC1a expression in astrocytes. Injection of rAAV-ASIC1a-shRNA into the dentate gyrus of the wide type TLE mouse model resulted in the inhibition of astrocytic ASIC1a expression and a reduction in spontaneous seizures
The findings of this study suggested a key role for ASIC1a in normal olfactory function.
Study suggests Acid-sensing ion channel 1a plays an inhibitory role in vasodilation in response to external protons, functional hyperemia, and exercise capacity.
Asic1 showed heightened mRNA expression, coherent with the repeated cross-fostering paradigm (RCF)-mice's respiratory hypersensitivity to CO2 and altered nociception.
Notch1 (show NOTCH1 Antibodies) signaling may be required for ASIC1a-mediated neurite growth and neuronal differentiation in neuroblastoma (show ARHGEF16 Antibodies) cells.
The authors observed no preference for sodium at the "GAS belt" in the central constriction. Instead, they identified a band of glutamate (show GRIN1 Antibodies) and aspartate side chains at the lower end of the pore that enables preferential sodium conduction.
Asic1a KO mice exhibited prominent deficits in multiple fear-related behaviors.
ASIC1a Deficient Mice Show Unaltered Neurodegeneration in the Subacute MPTP (show PTPN2 Antibodies) Model of Parkinson Disease
The manuscript demonstrates that postsynaptic neurons of the medial nucleus of the trapezoid body at the mouse calyx of Held synapse express functional homomeric Acid-sensing ion channel-1a (ASIC-1as) that can be activated by protons (coreleased with neurotransmitter from acidified synaptic vesicles). These ASIC-1as contribute to the generation of postsynaptic currents and, more relevant, to calcium influx, which could be
Data from models of hyperactive bladder suggest that ASIC1 is involved in ATP release from bladder mucosa stimulated by stretch/acid; studies include evidence ASIC isoforms are expressed in lateral wall, dome, trigone, and neck of detrusor/mucosa.
This gene encodes a member of the acid-sensing ion channel (ASIC) family of proteins, which are part of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. Members of the ASIC family are sensitive to amiloride and function in neurotransmission. The encoded proteins function in learning, pain transduction, touch sensation, and development of memory and fear. Alternatively spliced transcript variants have been described.
Cation channel, amiloride-sensitive, neuronal, 2
, acid-sensing ion channel 1
, acid-sensing ion channel 1a protein
, amiloride-sensitive cation channel 2, neuronal
, brain sodium channel 2
, proton gated cation channel ASIC1
, Amiloride-sensitive cation channel 2, neuronal
, acid sensing ion channel
, degenerin 2
, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1
, acid-sensing (proton-gated) ion channel 1