anti-Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2) Antibodies

ACCN2 encodes a member of the acid-sensing ion channel (ASIC) family of proteins, which are part of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. Additionally we are shipping Amiloride-Sensitive Cation Channel 2, Neuronal Proteins (7) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ACCN2 41 P78348
ACCN2 79123 P55926
ACCN2 11419 Q6NXK8
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Top anti-Amiloride-Sensitive Cation Channel 2, Neuronal Antibodies at antibodies-online.com

Showing 10 out of 149 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB <b>WB Suggested Anti-ACCN2 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:12500<br><b>Positive Control: </b>HT1080 cell lysate Host:  Rabbit  Target Name:  ASIC1  Sample Type:  MCF7 Whole Cell lysates  Antibody Dilution:  1.0ug/ml 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB Host: Rabbit Target Name: ASIC1 Sample Tissue: Human MCF7 Antibody Dilution: 1.0ug/ml Host: Rabbit Target Name: ASIC1 Sample Type: 721_B Whole Cell lysates Antibody Dilution: 1.0ug/ml 100 μL Log in to see 2 to 3 Days
$289.00
Details
Mouse Goat Un-conjugated ELISA, WB Western Blot: ACCN2 Antibody [NBP2-42507] - Analysis of Mouse fetal Brain lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 7 to 9 Days
$485.88
Details
Chicken Rabbit Un-conjugated WB Western blot analysis of ASIC1 expression in mouse brain (A), mouse spinal cord (B) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of ACCN2 Antibody (C-term) (ABIN653218) in CEM cell line lysates (35 µg/lane). ACCN2 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human brain tissue reacted with ACCN2 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$335.50
Details
Human Rabbit Un-conjugated EIA, FACS, IHC (p), WB ACCN2 Antibody (C-term) flow cytometric analysis of CEM cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. Formalin-fixed and paraffin-embedded human brain tissue reacted with ACCN2 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB WB Image Sample (30 ug of whole cell lysate) A: U87-MG 7.5% SDS PAGE antibody diluted at 1:500 100 μL Log in to see 1 to 2 Days
$358.60
Details
Mouse Mouse HRP ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-ASIC1 Monoclonal Antibody, Clone S271-44 . Tissue: Neuroblastoma cell line (SK-N-BE). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-ASIC1 Monoclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60min RT, 5min RT. Localization: Cell Membrane, Nucleus. Magnification: 60X. (A) DAPI (blue) nuclear stain (B) Phalloidin Texas Red F-Actin stain (C) ASIC1 Antibody (D) Composite. Western Blot analysis of Rat brain lysates showing detection of ASIC1 protein using Mouse Anti-ASIC1 Monoclonal Antibody, Clone S271-44 . Primary Antibody: Mouse Anti-ASIC1 Monoclonal Antibody  at 1:100, 1:250, 1:500, and 1:1000. 100 μg Log in to see 2 to 3 Days
$422.40
Details
Mouse Mouse FITC ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-ASIC1 Monoclonal Antibody, Clone S271-44 . Tissue: Neuroblastoma cell line (SK-N-BE). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-ASIC1 Monoclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60min RT, 5min RT. Localization: Cell Membrane, Nucleus. Magnification: 60X. (A) DAPI (blue) nuclear stain (B) Phalloidin Texas Red F-Actin stain (C) ASIC1 Antibody (D) Composite. Western Blot analysis of Rat brain lysates showing detection of ASIC1 protein using Mouse Anti-ASIC1 Monoclonal Antibody, Clone S271-44 . Primary Antibody: Mouse Anti-ASIC1 Monoclonal Antibody  at 1:100, 1:250, 1:500, and 1:1000. 100 μg Log in to see 2 to 3 Days
$426.80
Details
Mouse Mouse Alkaline Phosphatase (AP) ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-ASIC1 Monoclonal Antibody, Clone S271-44 . Tissue: Neuroblastoma cell line (SK-N-BE). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-ASIC1 Monoclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60min RT, 5min RT. Localization: Cell Membrane, Nucleus. Magnification: 60X. (A) DAPI (blue) nuclear stain (B) Phalloidin Texas Red F-Actin stain (C) ASIC1 Antibody (D) Composite. Western Blot analysis of Rat brain lysates showing detection of ASIC1 protein using Mouse Anti-ASIC1 Monoclonal Antibody, Clone S271-44 . Primary Antibody: Mouse Anti-ASIC1 Monoclonal Antibody  at 1:100, 1:250, 1:500, and 1:1000. 100 μg Log in to see 2 to 3 Days
$429.00
Details

ACCN2 Antibodies by Reactivity, Application, Clonality and Conjugate

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Top referenced anti-Amiloride-Sensitive Cation Channel 2, Neuronal Antibodies

  1. Mammalian Monoclonal ACCN2 Primary Antibody for ISt, IHC - ABIN1304544 : Lin, Sun, Chen: Genetic exploration of the role of acid-sensing ion channels. in Neuropharmacology 2015 (PubMed)
    Show all 3 Pubmed References

  2. Mouse (Murine) Polyclonal ACCN2 Primary Antibody for ELISA, WB - ABIN4277576 : Hoagland, Sherwood, Lee, Walker, Askwith: Identification of a calcium permeable human acid-sensing ion channel 1 transcript variant. in The Journal of biological chemistry 2010 (PubMed)

More Antibodies against Amiloride-Sensitive Cation Channel 2, Neuronal Interaction Partners

Human Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2) interaction partners

  1. Study shows that bile acids potentiate proton-activated currents in Xenopus laevis oocytes expressing human acid-sensing ion channel. Site-directed mutagenesis demonstrated that the amino acid residue G433 is critically involved in the potentiating effect of bile acids on ASIC1a activation by protons.

  2. Genetic variants in the ACCN2 are associated with differential sensitivity to CO2.

  3. The deactivation of ASIC1 was steeply dependent on the pH, spanning nearly three orders of magnitude from extremely fast at pH 8 to very slow at pH 7.

  4. Results show that the "acidic pocket," the binding site of several toxins, is not essential for channel function but has, rather, a modulatory role. Furthermore, the study describes the structural rearrangements occurring in this domain during ASIC activity, and highlight the importance of the "palm" domain in channel opening and current decay.

  5. our results suggest that ASIC1a is critical for liver cancer cell proliferation and its deregulation is frequently linked to liver cancer

  6. the data demonstrate a functional link between ASICs and [Ca(2 (show CA2 Antibodies)+)]i/RhoA (show RHOA Antibodies) pathway, which contributes to the acidity-induced epithelial-mesenchymal transition.

  7. ASIC1 contributes to breast cancer pathogenesis in response to acidic tumor microenvironments

  8. The results show that acid-sensing ion channel 1, acid-sensing ion channel 2 (show ACCN1 Antibodies), and acid-sensing ion channel 3 (show ACCN3 Antibodies) are expressed in A549 cells at the messenger RNA and protein levels, and acid-sensing ion channel-like currents were elicited by extracellular acid stimuli.

  9. Data show that acid sensing ion channel 1a (ASIC1a) mediated calcium influx, which resulted in the activation of PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) signaling and increased drug resistance, suggesting that ASIC1a/Ca(2 (show CA2 Antibodies)+)/PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) signaling represents a pathway that regulates drug resistance, thus offering a potential target for chemotherapy of hepatocellular carcinoma (HCC (show FAM126A Antibodies)).

  10. Downregulation of ASIC1 inhibits gastric cancer growth via decreasing autophagy, therefore this strongly suggests a therapeutic role for ASIC1 in gastric cancer.

Mouse (Murine) Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2) interaction partners

  1. These data demonstrate the involvement of an ASIC1a-mediated insular synaptic depression mechanism in extinction learning.

  2. ASIC1a expression in astrocytes. Injection of rAAV-ASIC1a-shRNA into the dentate gyrus of the wide type TLE mouse model resulted in the inhibition of astrocytic ASIC1a expression and a reduction in spontaneous seizures

  3. The findings of this study suggested a key role for ASIC1a in normal olfactory function.

  4. Study suggests Acid-sensing ion channel 1a plays an inhibitory role in vasodilation in response to external protons, functional hyperemia, and exercise capacity.

  5. Asic1 showed heightened mRNA expression, coherent with the repeated cross-fostering paradigm (RCF)-mice's respiratory hypersensitivity to CO2 and altered nociception.

  6. Notch1 (show NOTCH1 Antibodies) signaling may be required for ASIC1a-mediated neurite growth and neuronal differentiation in neuroblastoma (show ARHGEF16 Antibodies) cells.

  7. The authors observed no preference for sodium at the "GAS belt" in the central constriction. Instead, they identified a band of glutamate (show GRIN1 Antibodies) and aspartate side chains at the lower end of the pore that enables preferential sodium conduction.

  8. Asic1a KO mice exhibited prominent deficits in multiple fear-related behaviors.

  9. ASIC1a Deficient Mice Show Unaltered Neurodegeneration in the Subacute MPTP (show PTPN2 Antibodies) Model of Parkinson Disease

  10. The manuscript demonstrates that postsynaptic neurons of the medial nucleus of the trapezoid body at the mouse calyx of Held synapse express functional homomeric Acid-sensing ion channel-1a (ASIC-1as) that can be activated by protons (coreleased with neurotransmitter from acidified synaptic vesicles). These ASIC-1as contribute to the generation of postsynaptic currents and, more relevant, to calcium influx, which could be

Pig (Porcine) Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2) interaction partners

  1. Data from models of hyperactive bladder suggest that ASIC1 is involved in ATP release from bladder mucosa stimulated by stretch/acid; studies include evidence ASIC isoforms are expressed in lateral wall, dome, trigone, and neck of detrusor/mucosa.

Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2) Antigen Profile

Protein Summary

This gene encodes a member of the acid-sensing ion channel (ASIC) family of proteins, which are part of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. Members of the ASIC family are sensitive to amiloride and function in neurotransmission. The encoded proteins function in learning, pain transduction, touch sensation, and development of memory and fear. Alternatively spliced transcript variants have been described.

Gene names and symbols associated with ACCN2

  • acid sensing ion channel subunit 1 (ASIC1) antibody
  • acid sensing ion channel subunit 1 (Asic1) antibody
  • acid sensing ion channel subunit 1 (asic1) antibody
  • acid-sensing (proton-gated) ion channel 1 (Asic1) antibody
  • SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 (SMARCD1) antibody
  • Accn2 antibody
  • AI843610 antibody
  • ASIC antibody
  • ASIC1 antibody
  • ASIC1a antibody
  • B530003N02Rik antibody
  • BNaC2 antibody

Protein level used designations for ACCN2

Cation channel, amiloride-sensitive, neuronal, 2 , acid-sensing ion channel 1 , acid-sensing ion channel 1a protein , amiloride-sensitive cation channel 2, neuronal , brain sodium channel 2 , BNaC2 , proton gated cation channel ASIC1 , Amiloride-sensitive cation channel 2, neuronal , acid sensing ion channel , degenerin 2 , SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 , acid-sensing (proton-gated) ion channel 1

GENE ID SPECIES
41 Homo sapiens
79123 Rattus norvegicus
426883 Gallus gallus
451888 Pan troglodytes
477612 Canis lupus familiaris
538244 Bos taurus
100194955 Salmo salar
11419 Mus musculus
100355858 Oryctolagus cuniculus
713320 Macaca mulatta
100517467 Sus scrofa
100059851 Equus caballus
100720903 Cavia porcellus
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