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ACCN4 belongs to the superfamily of acid-sensing ion channels, which are proton-gated, amiloride-sensitive sodium channels. Additionally we are shipping Amiloride-Sensitive Cation Channel 4, Pituitary Proteins (6) and many more products for this protein.
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Acid-sensing ion channel (ASIC) 4 predominantly localizes to an early endosome-related organelle upon heterologous expression
Data show that transfected ASIC4 is targeted to the plasma membrane in CHO-K1 cells, where it associates with ASIC1a and downregulates exogenous ASIC1a expression.
Study employed a radioactive in situ hybridization method to thoroughly investigate the distribution of Acid-sensing ion channel 4 (ASIC4) transcripts in the adult wild-type mouse brain. The resultant data indicate that the ASIC4 mRNAs were substantially expressed in many areas of the brain.
This study demonstrated that ASIC4 may modulate fear and anxiety by counteracting ASIC1a activity in the brain.
This gene belongs to the superfamily of acid-sensing ion channels, which are proton-gated, amiloride-sensitive sodium channels. These channels have been implicated in synaptic transmission, pain perception as well as mechanoperception. This gene is predominantly expressed in the pituitary gland, and was considered a candidate for paroxysmal dystonic choreoathetosis (PDC), a movement disorder, however, no correlation was found between mutations in this gene and PDC.
amiloride-sensitive cation channel 4, pituitary
, amiloride-sensitive cation channel 4, pituitary, isoform 1
, amiloride-sensitive cation channel 4-like
, acid-sensing ion channel 4
, amiloride-sensitive cation channel family member 4, pituitary
, brain sodium channel 4
, putative acid-sensing ion channel
, spinal chord ASIC