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ACY1 encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. Additionally we are shipping Aminoacylase 1 Proteins (15) and Aminoacylase 1 Kits (13) and many more products for this protein.
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Human Polyclonal Aminoacylase 1 Primary Antibody for ELISA, WB - ABIN559776 : Van Coster, Gerlo, Giardina, Engelke, Smet, De Praeter, Meersschaut, De Meirleir, Seneca, Devreese, Leroy, Herga, Perrier, Wevers, Lissens: Aminoacylase I deficiency: a novel inborn error of metabolism. in Biochemical and biophysical research communications 2005 (PubMed) Show all 2 Pubmed References
Human Polyclonal Aminoacylase 1 Primary Antibody for ICC, IF - ABIN441372 : Sommer, Christensen, Schwenger, Seul, Haas, Olbrich, Omran, Sass: The molecular basis of aminoacylase 1 deficiency. in Biochimica et biophysica acta 2011 (PubMed)
Human Monoclonal Aminoacylase 1 Primary Antibody for IF, IHC (p) - ABIN559777 : Jansen, van Rijswijk, Teubel, van Weerden, Reneman, van den Bemd, Roobol, Bangma, Staal, Jenster: Profiling of antibody production against xenograft-released proteins by protein microarrays discovers prostate cancer markers. in Journal of proteome research 2012 (PubMed)
with the elevated level in the disease progression of Chronic hepatitis B (CHB), ACY1 autoantibody may be a valuable serum biomarker for discriminating HBVrelated liver cirrhosis from CHB.
Biochemical analysis showed absence of ACY1 enzyme activity in the patient's fibroblasts.
ACY1 acts as a tumor suppressor in hepatocellular carcinoma.
Report serum aminoacylase-1 as a novel biomarker with potential prognostic utility for long-term outcome in renal transplant recipients with delayed graft function.
Case Report: ACY1-deficient patient presenting with autistic features.
We concluded that ACY1 expression in colorectal cancer varies with stage and appears to play a role in cell proliferation and apoptosis
These data suggest that aminoacylase expression is dysregulated in neuroblastoma (show ARHGEF16 Antibodies).
aminoacylase 1 proteins with the mutations p.Arg378Trp, p.Arg378Gln and p.Arg393His were also detected in Western blot analysis
by complementing different active site mutants of human aminoacylase-1, study shows that catalysis occurs at the dimer interface
Genetic deficiency of ACY1 leads to functional ACY1 deficiency and excretion of N-acetylated amino acids.
Apo (show C9orf3 Antibodies)-aminoacylase followed similar rules as Holo-enzyme, which suggested the zinc ion may play more important roles on activity other than structure
Based on site-directed mutagenesis, homology modeling and substrate docking studies, a revised catalytic mechanism for porcine metalloenzyme aminoacylase 1 has been proposed.
T347S variant of human Acy1 exhibited markedly increased catalytic efficiency against N-benzoylamino acids
This gene encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. This gene is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ABHD14A (abhydrolase domain containing 14A) gene, as represented in GeneID:100526760. A related pseudogene has been identified on chromosome 18.
aminoacylase-1 , aminoacylase 1 , N-acyl-L-amino-acid amidohydrolase , acylase , ACY IA , ACY IB , ACY-1A , ACY-1B , aminoacylase-1A , aminoacylase-1B , ACY-1 , N-acylamino acid aminohydrolase (Aminoacylase 1)