anti-Aminoacylase 1 (ACY1) Antibodies

ACY1 encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. Additionally we are shipping Aminoacylase 1 Kits (17) and Aminoacylase 1 Proteins (16) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ACY1 95 Q03154
ACY1 109652 Q99JW2
ACY1 300981 Q6AYS7
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Top anti-Aminoacylase 1 Antibodies at antibodies-online.com

Showing 10 out of 109 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated IF, IHC, IP, WB Immunofluorescence of monoclonal antibody to ACY1 on HeLa cell (antibody concentration 10 µg/mL). ACY1 monoclonal antibody (M01), clone 4F1-B7 Western Blot analysis of ACY1 expression in K-562. 100 μg Log in to see 8 to 11 Days
$527.50
Details
Dog Mouse Un-conjugated FACS, IHC, IHC (p), WB 100 μL Log in to see 11 to 14 Days
$507.83
Details
Dog Mouse Un-conjugated FACS, IHC, IHC (p), WB 100 μL Log in to see 11 to 14 Days
$507.83
Details
Human Mouse Un-conjugated FACS, IHC, IHC (p), WB 100 μL Log in to see 11 to 14 Days
$507.83
Details
Human Mouse Un-conjugated FACS, IHC, IHC (p), WB 100 μL Log in to see 11 to 14 Days
$507.83
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB WB Image Sample (30 ug of whole cell lysate) A: H1299 10% SDS PAGE antibody diluted at 1:1000 IHC-P Image Aminoacylase 1 antibody [N2C3-2] detects Aminoacylase-1 protein at cytoplasm on human placenta by immunohistochemical analysis. Sample: Paraffin-embedded placenta. Aminoacylase 1 antibody [N2C3-2] , dilution: 1:100. 100 μL Log in to see 3 to 4 Days
$466.18
Details
Human Mouse Un-conjugated FACS, WB 100 μL Log in to see 11 to 14 Days
$507.83
Details
Human Mouse Un-conjugated ELISA, WB 100 μg Log in to see 14 to 16 Days
$247.82
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE) Anti-ACY1 / Aminoacylase 1 antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μL Log in to see 11 to 14 Days
$484.00
Details
Human Mouse Un-conjugated FACS, IHC, WB HEK293T cells transfected with either RC201284 overexpress plasmid (Red) or empty vector control plasmid (Blue) were immunostained by anti-ACY1 antibody (ABIN2454790), and then analyzed by flow cytometry. HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ACY1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-ACY1. 0.1 mL Log in to see 2 to 3 Days
$462.00
Details

Top referenced anti-Aminoacylase 1 Antibodies

  1. Human Polyclonal Aminoacylase 1 Primary Antibody for ELISA, WB - ABIN559776 : Van Coster, Gerlo, Giardina, Engelke, Smet, De Praeter, Meersschaut, De Meirleir, Seneca, Devreese, Leroy, Herga, Perrier, Wevers, Lissens: Aminoacylase I deficiency: a novel inborn error of metabolism. in Biochemical and biophysical research communications 2005 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal Aminoacylase 1 Primary Antibody for ICC, IF - ABIN441372 : Sommer, Christensen, Schwenger, Seul, Haas, Olbrich, Omran, Sass: The molecular basis of aminoacylase 1 deficiency. in Biochimica et biophysica acta 2011 (PubMed)

  3. Human Monoclonal Aminoacylase 1 Primary Antibody for IF, IHC (p) - ABIN559777 : Jansen, van Rijswijk, Teubel, van Weerden, Reneman, van den Bemd, Roobol, Bangma, Staal, Jenster: Profiling of antibody production against xenograft-released proteins by protein microarrays discovers prostate cancer markers. in Journal of proteome research 2012 (PubMed)

More Antibodies against Aminoacylase 1 Interaction Partners

Human Aminoacylase 1 (ACY1) interaction partners

  1. with the elevated level in the disease progression of Chronic hepatitis B (CHB), ACY1 autoantibody may be a valuable serum biomarker for discriminating HBVrelated liver cirrhosis from CHB.

  2. Biochemical analysis showed absence of ACY1 enzyme activity in the patient's fibroblasts.

  3. ACY1 acts as a tumor suppressor in hepatocellular carcinoma.

  4. Report serum aminoacylase-1 as a novel biomarker with potential prognostic utility for long-term outcome in renal transplant recipients with delayed graft function.

  5. Case Report: ACY1-deficient patient presenting with autistic features.

  6. We concluded that ACY1 expression in colorectal cancer varies with stage and appears to play a role in cell proliferation and apoptosis

  7. These data suggest that aminoacylase expression is dysregulated in neuroblastoma.

  8. aminoacylase 1 proteins with the mutations p.Arg378Trp, p.Arg378Gln and p.Arg393His were also detected in Western blot analysis

  9. by complementing different active site mutants of human aminoacylase-1, study shows that catalysis occurs at the dimer interface

  10. first report of a patient with aminoacylase I deficiency

  11. Genetic deficiency of ACY1 leads to functional ACY1 deficiency and excretion of N-acetylated amino acids.

  12. Because hK1 amidase activity is significantly lower in urine of systolic HF patients, it can be supposed that activity of renal kallikrein-kinin system may be suppressed in this systolic heart failure.

  13. T347S variant of human Acy1 exhibited markedly increased catalytic efficiency against N-benzoylamino acids

Pig (Porcine) Aminoacylase 1 (ACY1) interaction partners

  1. Apo-aminoacylase followed similar rules as Holo-enzyme, which suggested the zinc ion may play more important roles on activity other than structure

  2. Based on site-directed mutagenesis, homology modeling and substrate docking studies, a revised catalytic mechanism for porcine metalloenzyme aminoacylase 1 has been proposed.

  3. T347S variant of human Acy1 exhibited markedly increased catalytic efficiency against N-benzoylamino acids

Aminoacylase 1 (ACY1) Antigen Profile

Protein Summary

This gene encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. This gene is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ABHD14A (abhydrolase domain containing 14A) gene, as represented in GeneID:100526760. A related pseudogene has been identified on chromosome 18.

Gene names and symbols associated with anti-Aminoacylase 1 (ACY1) Antibodies

  • aminoacylase 1 (ACY1) antibody
  • aminoacylase 1 (acy1) antibody
  • aminoacylase 1, gene 1 S homeolog (acy1.1.S) antibody
  • aminoacylase 1, gene 1 (acy1.1) antibody
  • aminoacylase 1 (Acy1) antibody
  • 1110014J22Rik antibody
  • Acy-1 antibody
  • ACY1 antibody
  • Acy1a antibody
  • Acy1b antibody
  • ACY1D antibody
  • acylase antibody
  • si:zfos-226g1.1 antibody
  • zgc:55605 antibody
  • zgc:76955 antibody

Protein level used designations for anti-Aminoacylase 1 (ACY1) Antibodies

aminoacylase-1 , aminoacylase 1 , N-acyl-L-amino-acid amidohydrolase , acylase , ACY IA , ACY IB , ACY-1A , ACY-1B , aminoacylase-1A , aminoacylase-1B , ACY-1 , N-acylamino acid aminohydrolase (Aminoacylase 1)

GENE ID SPECIES
100060631 Equus caballus
393970 Danio rerio
446741 Xenopus laevis
460414 Pan troglodytes
496883 Xenopus (Silurana) tropicalis
100344479 Oryctolagus cuniculus
95 Homo sapiens
109652 Mus musculus
300981 Rattus norvegicus
396930 Sus scrofa
768058 Bos taurus
476602 Canis lupus familiaris
100171519 Pongo abelii
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