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AADAT encodes a protein that is highly similar to mouse and rat kynurenine aminotransferase II. Additionally we are shipping AADAT Antibodies (90) and AADAT Proteins (12) and many more products for this protein.
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he optimised method of protein production provides a fast and reliable technique to generate large quantities of active human KAT2 suitable for future small-molecule lead compound screening and structural design work.
association of SNP AADAT+401C/T with the host immune response to bacterial meningitis, suggesting that this SNP may affect the host ability in recruitment of leukocytes to the infection site
analysis of the crystal structure of kynurenine aminotransferase II
analysis of the crystal structure of human kynurenine aminotransferase II
A human cDNA encodes a 425-residue protein with a mitochondrial cleavage signal and a pyridoxal-phosphate binding site, ~70% identical to the mouse and rat AADAT orthologs. Bacterial expression studies confirm that the gene encodes AADAT activity.
human KAT III/CCBL2 possesses cysteine S-conjugate beta-lyase activity, as does mouse KAT II
This study showed that KAT II KO mice show the expected decrease in extracellular kynurenic acid levels, and that this reduction is accompanied by a significant increase in extracellular glutamate (show GRIN1 ELISA Kits).
The activity of mouse KAT II was not significantly inhibited by any proteinogenic amino acids at equimolar concentrations and half-life was 27.4 minutes at 65 degree C.
Alpha7* nAChR (show CHRNA7 ELISA Kits) and NMDA receptor functions were studied in kynurenine aminotransferase II null mice(mKat-2-/- mice). At 21 postnatal days, mKat-2-/- mice had lower hippocampal kynurenic acid levels and more spontaneous locomotor activity than control mice
Results show that gene targeting of kynurenine aminotransferase II (KAT) in mice leads to early and transitory decreases in brain KAT activity and kynurenic acid levels with commensurate behavioral and neuropathological changes.
This gene encodes a protein that is highly similar to mouse and rat kynurenine aminotransferase II. The rat protein is a homodimer with two transaminase activities. One activity is the transamination of alpha-aminoadipic acid, a final step in the saccaropine pathway which is the major pathway for L-lysine catabolism. The other activity involves the transamination of kynurenine to produce kynurenine acid, the precursor of kynurenic acid which has neuroprotective properties. Two alternative transcripts encoding the same isoform have been identified, however, additional alternative transcripts and isoforms may exist.
, alpha-aminoadipate aminotransferase
, kynurenine/alpha-aminoadipate aminotransferase, mitochondrial-like
, 2-aminoadipate aminotransferase
, 2-aminoadipate transaminase
, L kynurenine/alpha aminoadipate aminotransferase
, kynurenine aminotransferase II
, kynurenine--oxoglutarate aminotransferase II
, kynurenine--oxoglutarate transaminase 2
, kynurenine--oxoglutarate transaminase II
, kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
, kynurenine aminotransferase 2