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ANAPC1 encodes a subunit of the anaphase-promoting complex.
Showing 10 out of 143 products:
Human Polyclonal ANAPC1 Primary Antibody for IP, WB - ABIN257717
Schiffman, Rodriguez, Chen, Wacholder, Herrero, Hildesheim, Desalle, Befano, Yu, Safaeian, Sherman, Morales, Guillen, Alfaro, Hutchinson, Solomon, Castle, Burk: A population-based prospective study of carcinogenic human papillomavirus variant lineages, viral persistence, and cervical neoplasia. in Cancer research 2010
Show all 2 Pubmed References
Human Polyclonal ANAPC1 Primary Antibody for ELISA, FACS - ABIN4281012
Spurlock, Tossberg, Olsen, Aune: Cutting Edge: Chronic NF-κB Activation in CD4+ T Cells in Rheumatoid Arthritis Is Genetically Determined by HLA Risk Alleles. in Journal of immunology (Baltimore, Md. : 1950) 2015
Data show that FZR1 (Fzr (show FZR1 Antibodies)), a cofactor of the multi-subunit E3 ligase complex anaphase-promoting complex/cyclosome (APC (show APC Antibodies)/C), represents a therapeutic target in myeloma.
in the Alzheimer's disease (AD)mouse model APP (show APP Antibodies)/PS1 (show PSEN1 Antibodies), lower cdh1 (show CDH1 Antibodies) levels were observed in pyramidal neurons in CA1 (show CA1 Antibodies) when compared to age-matched wildtype mice. In this review, we provide a complete list of APC (show APC Antibodies)/C substrates that are involved in the nervous system and we discuss their functions. We also summarize recent studies that show neurobiological effects in cdh1 (show CDH1 Antibodies) knockout mouse models.
cryo-EM structure of an APC (show APC Antibodies)/C-Cdh1 (show CDH1 Antibodies) complex with Apc1 (show SLC25A24 Antibodies)(WD40 (show DCAF12L2 Antibodies)) deleted showed that the mutant APC (show APC Antibodies)/C is locked into an inactive conformation in which the UbcH10 (show UBE2C Antibodies)-binding site of the catalytic module is inaccessible. Additionally, an EM density for Apc15 (show ANAPC15 Antibodies) is not visible
The ABBA (show MTSS1L Antibodies)-KEN (show PCNT Antibodies)-ABBA (show MTSS1L Antibodies) amino acid motif cassette holds the Mitotic Checkpoint (show BUB3 Antibodies) Complex (MCC (show MCC Antibodies)) onto the Anaphase-Promoting Complex-Cyclosome (APC (show APC Antibodies)/C) by binding the two Cdc20 (show CDC20 Antibodies) molecules in the MCC (show MCC Antibodies)-APC (show APC Antibodies)/C complex.
findings suggest a tumor suppressor role for APC (show APC Antibodies)/C(Cdh1 (show CDH1 Antibodies)) in melanocytes and that targeting PAX3 (show PAX3 Antibodies) may be a strategy for treating melanoma.
Human Cytomegalovirus UL21a but not UL97 can disrupt APC (show APC Antibodies)/C function, leading to the accumulation of substrates and that UL21a is necessary and sufficient to induce the degradation of APC1 (show SLC25A24 Antibodies), in addition to the previously reported APC4 (show ANAPC4 Antibodies) and APC5 (show ANAPC5 Antibodies).
Data indicate that regulation of Rad17 (show RAD17 Antibodies) turnover is through the Cdh1 (show CDH1 Antibodies)/anaphase-promoting complex pathway in breast cancer cells.
EYA1 (show EYA1 Antibodies) is efficiently degraded during mitotic exit in a ANAPC1-dependent manner and these two proteins physically interact.
analysis of ubiquitylation of p53 (show TP53 Antibodies) by the APC (show APC Antibodies)/C inhibitor Trim39 (show TRIM39 Antibodies)
Single nucleotide polymorhpisms of ANAPC1 were associated with nicotine dependence.
This gene encodes a subunit of the anaphase-promoting complex. This complex is an E3 ubiquitin ligase that regulates progression through the metaphase to anaphase portion of the cell cycle by ubiquitinating proteins which targets them for degradation.
anaphase-promoting complex 1 (meiotic checkpoint regulator)
, anaphase-promoting complex subunit 1
, cyclosome subunit 1
, mitotic checkpoint regulator
, testis-specific gene 24 protein
, anaphase promoting complex subunit 1
, meiotic check point regulator