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ANAPC7 encodes a tetratricopeptide repeat containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. Additionally we are shipping ANAPC7 Antibodies (17) and many more products for this protein.
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The results showed that APC2 and APC7 subunits were both over expressed in cancer cell lines
Data indicate that additional density present in the anaphase-promoting complex (APC/C) structure, proximal to Apc3/Cdc27 of the (tetratricopeptide repeat) lobe, is assigned to the TPR subunit Apc7, a subunit specific to vertebrate APC/C.
Studies indicate that APC/C(Cdh1) is required to maintain genomic stability.
dysregulation of APC activity, possibly through downregulation of APC7, may be associated with tumorigenesis in breast cancer
APC5 and APC7 suppress E1A-mediated transformation in a CBP/p300-dependent manner, indicating that these components of the APC/C may be targeted during cellular transformation
Expression of ANAPC7 in fibroadenomas and phylloides tumors of breast is reported.
The crystal structure of quad mutant of nApc7 (N-terminal fragment, residues 1-147) of human Apc7 at a resolution of 2.5 A, is reported.
This gene encodes a tetratricopeptide repeat containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for proper protein ubiquitination function of APC/C and for the interaction of APC/C with certain transcription coactivators. Multiple transcript variants encoding different isoforms have been found for this gene.
anaphase promoting complex subunit 7 , anaphase-promoting complex subunit 7 , cyclosome subunit 7 , prediabetic NOD sera-reactive autoantigen