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Annexin VI belongs to a family of calcium-dependent membrane and phospholipid binding proteins. Additionally we are shipping Annexin A6 Proteins (20) and Annexin A6 Kits (18) and many more products for this protein.
Showing 10 out of 152 products:
Human Monoclonal ANXA6 Primary Antibody for IF, IP - ABIN967890
Babiychuk, Draeger: Annexins in cell membrane dynamics. Ca(2+)-regulated association of lipid microdomains. in The Journal of cell biology 2000
Show all 5 Pubmed References
Human Monoclonal ANXA6 Primary Antibody for IF, IP - ABIN967891
Babiychuk, Palstra, Schaller, Kämpfer, Draeger: Annexin VI participates in the formation of a reversible, membrane-cytoskeleton complex in smooth muscle cells. in The Journal of biological chemistry 2000
Show all 5 Pubmed References
Human Polyclonal ANXA6 Primary Antibody for ICC, IF - ABIN4280822
Nakayama, Fukuda, Inoue, Nishida-Fukuda, Shirakata, Hashimoto, Higashiyama: Cell surface annexins regulate ADAM-mediated ectodomain shedding of proamphiregulin. in Molecular biology of the cell 2012
Show all 2 Pubmed References
Human Polyclonal ANXA6 Primary Antibody for WB - ABIN947559
Ramírez-Mata, Michalak, Mendoza-Hernández, León-Del-Río, González-Noriega: Annexin VI is a mannose-6-phosphate-independent endocytic receptor for bovine ?-glucuronidase. in Experimental cell research 2011
Immunoprecipitation of the products obtained from the transcription/translation system using various anti-annexin A6 antibodies confirmed the presence of several isoforms and suggested that this protein might be present in different configurations.
AnxA6 protein in adipocytes was upregulated by oxidative stress which might trigger AnxA6 induction in adipose tissues and contribute to impaired fat storage and adiponectin release.
High ANXA6 expression is associated with neoplasms.
stable or transient AnxA6 overexpression in HuH7 cells led to elevated lipid droplet numbers/size and neutral lipid staining under control conditions
Annexin VI is enriched in calcifying valve interstitial cell derived-matrix vesicles from patients with end stage renal disease-induced hypercalcemia and aortic valve calcification.
These findings suggest that cancer-associated fibroblasts -tumor cell crosstalk supported by ANXA6+ EVs is predictive of pancreatic ductal adenocarcinoma aggressiveness, highlighting a therapeutic target and potential biomarker for pancreatic ductal adenocarcinoma.
The current study shows that AnxA6 is specifically reduced in human hepatocellular carcinoma suggesting a role of this protein in hepatocarcinogenesis.
Data suggest that reduced ability of AnxA6-expressing cells to migrate is associated with decreased cell surface expression of integrins alphaVbeta3 and alpha5beta1.
ANXA6 was detected as a novel systemic lupus erythematosus susceptibility gene, with several single-nucleotide polymorphisms (SNPs) contributing independently to the association with disease
ANXA6 is a EZH2 (show EZH2 Antibodies) target gene involving gastric cellular proliferation.
AnxA6 regulates IL-2 (show IL2 Antibodies) homeostasis and sensitivity in T cells by sustaining a lipid raft-like membrane environment.
morphological analysis of liver sections from annexin A6-KO mice revealed significantly lower lipid droplet numbers compared to wildtype animals
Evidence for annexin A6-dependent plasma membrane remodelling of lipid domains
Transient knockdown of annexin A6 and calsequestrin 1 (show CASQ1 Antibodies) protein of high-active mice with vivo-morpholinos resulted in decreased physical activity levels (P = 0.001).
Anxa6 is a modifier of muscular dystrophy and membrane repair after injury.
anxA6 inhibits Drp1 (show CRMP1 Antibodies) activity, and Ca(2 (show CA2 Antibodies)+)-binding to anxA6 relieves this inhibition to permit Drp1 (show CRMP1 Antibodies)-mediated mitochondrial
cell surface annexin VI may function as an acidic pH binding site or receptor and may also function as a co-receptor with LRP-1 (show LRP1 Antibodies) at neutral pH
Annexin VI regulation of myocardial contraction.
distinct functions of AnxA6 isoforms in membrane dynamics
AnxA6 is a novel receptor that mediates the endocytosis of bovine beta-glucuronidase (show GUSB Antibodies).
The results showed that alkaline phosphatase activity was significantly increased in matrix vesicles from calcified bovine vascular smooth muscle cells (BVSMCs) compared with noncalcified BVSMCs, as was annexin II (show ANXA2 Antibodies) and VI content and (45)Ca uptake.
Annexin VI belongs to a family of calcium-dependent membrane and phospholipid binding proteins. Several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. The annexin VI gene is approximately 60 kbp long and contains 26 exons. It encodes a protein of about 68 kDa that consists of eight 68-amino acid repeats separated by linking sequences of variable lengths. It is highly similar to human annexins I and II sequences, each of which contain four such repeats. Annexin VI has been implicated in mediating the endosome aggregation and vesicle fusion in secreting epithelia during exocytosis. Alternatively spliced transcript variants have been described.
, annexin A6-like
, 67 kDa calelectrin
, annexin VI (p68)
, calcium-binding protein p68
, calphobindin II
, lipocortin VI
, annexin VI, p68
, CBP 65/67
, annexin VI
, calcium-binding protein 65/67
, calcium-binding protein CATA 65/67
, ANX VI
, annexin 6
, calcium- and phospholipid-binding protein
, lipid-dependent Ca(2+)-binding protein annexin VI