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ANO6 encodes a multi-pass transmembrane protein that belongs to the anoctamin family. Additionally we are shipping Anoctamin 6 Antibodies (35) and Anoctamin 6 Proteins (6) and many more products for this protein.
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TMEM16F knockout did not affect Ca2 (show CA2 ELISA Kits)+ signaling and Ca2 (show CA2 ELISA Kits)+-activated whole cell currents in podocytes. TMEM16F shows little effect on basal properties of podocytes and does not appear to be essential for renal function.
TMEM16F interaction with phosphatidylinositol-(4, 5)-bisphosphate works synergistically with membrane depolarization to facilitate Ca(2 (show CA2 ELISA Kits)+)-gating of TMEM16F.
TMEM16F is an essential component of the microglial response to injury and suggest the importance of microglial phagocytosis in the pathogenesis of neuropathic pain.
The present data demonstrate the activation of ANO6 during necroptosis, which, however, is not essential for cell death.
TMEM16F deficiency results in sustained signaling and augmented T cell activation.
Platelet TMEM16F activity contributes significantly to hemostasis and thrombosis but not cerebral thromboinflammation.
ANO6 produces volume-regulated anion currents and controls cell volume in four unrelated cell types.
deficiency in Ano6 resulted in reduced viability with increased bleeding time
Although broadly expressed, Ano6 has no role in intestinal cholinergic Cl- secretion.
Ano6 mediates effects essential for innate immunity downstream of P2X7 (show P2RX7 ELISA Kits) receptors in macrophages.
ICl,Swell, and cell volume are regulated by Ano6. The findings suggest a novel clinically-relevant approach for altering cell volume, and thereby outflow resistance, by targeting Ano6.
TMEM16F modifies viability of Human Embryonic Kidney cells via its function as a phospholipid scramblase and activation of AKT (show AKT1 ELISA Kits) signaling pathways.
Ion channel and lipid scramblase activity associated with expression of TMEM16F/ANO6 isoforms
ANO6 is highly expressed in apoptotic cyst epithelial cells of human polycystic kidneys.
Homology modeling shows that the scramblase domain forms an unusual hydrophilic cleft that faces the lipid bilayer and may function to facilitate translocation of phospholipid between membrane leaflets.
using human osteoblasts and osteoblasts from Ano6(-/-) and WT mice, we demonstrate that NCX1 (show SLC8A1 ELISA Kits) requires Ano6 to efficiently translocate Ca(2 (show CA2 ELISA Kits)+) out of osteoblasts into the calcifying bone matrix
TMEM16A (show ANO1 ELISA Kits) and -16F use a similar mechanism for sorting to plasma membrane and protein stabilization, but their functional domains significantly differ
Anoo6 induces a chloride ion conductance along with a smaller nonselective cation conductance that is activated either calcium ion dependently (ionomycin) or calcium independently(fas receptor (show FAS ELISA Kits)), but not during mitochondrial apoptosis.
This gene encodes a multi-pass transmembrane protein that belongs to the anoctamin family. This protein is an essential component for the calcium-dependent exposure of phosphatidylserine on the cell surface. The scrambling of phospholipid occurs in various biological systems, such as when blood platelets are activated, they expose phosphatidylserine to trigger the clotting system. Mutations in this gene are associated with Scott syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, transmembrane protein 16F
, abnormal X segregation-like
, Transmembrane protein 16F
, SCAN channel
, small-conductance calcium-activated nonselective cation channel