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Microsomal arylacetamide deacetylase competes against the activity of cytosolic arylamine N-acetyltransferase, which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens [provided by RefSeq, Jul 2008]..
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Human Monoclonal AADAC Primary Antibody for ELISA, WB - ABIN513029
Watanabe, Fukami, Nakajima, Takamiya, Aoki, Yokoi: Human arylacetamide deacetylase is a principal enzyme in flutamide hydrolysis. in Drug metabolism and disposition: the biological fate of chemicals 2009
Show all 5 Pubmed References
Data suggest that metabolism (and possibly pharmacokinetics) of hypnotic nitrazepam involves liver enzymes AOX1 (aldehyde oxidase 1 (show AOX1 Antibodies)), NAT2 (N-acetyltransferase 2 (show NAT2 Antibodies)), AADAC (arylacetamide deacetylase), and CYP3A4 (cytochrome P450 3A4 (show CYP3A4 Antibodies)).
Data suggest that AADAC in hepatocyte microsomes hydrolyzes ketoconazole, a synthetic imidazole antifungal agent, to N-deacetyl ketoconazole and thus triggers hepatocellular toxicity.
AADAC deletion is a candidate susceptibility factor for Gilles de la Tourette Syndrome
Translational N-glycosylation of AADAC plays a crucial role in regulating AADAC enzyme activity.
Lipolysis of cellular TG and VLDL production were impaired in HCV infected cells during the early peak of viral infection. This was partially explained by an apparent deficiency of a putative TG lipase (show LIPG Antibodies), arylacetamide deacetylase (AADAC).
An AADAC*3 allele yields decreased enzyme activity in liver microsomes.
human AADAC was the enzyme responsible for the deacetylation of rifamycins and would affect the induction rate of drug-metabolizing enzymes by rifamycins and their induced hepatotoxicity.
two intrinsic endoplasmic reticulum (ER) proteins, 11beta-hydroxysteroid dehydrogenase, isozyme 1 (11beta-HSD (show CHST3 Antibodies)) and the 50-kDa esterase (show ESD Antibodies) (E3), sharing some amino acid sequence motifs in their N-terminal transmembrane (TM) domains.
Expression of AADA cDNA in McArdle-RH7777 cells significantly reduced intracellular triacylglycerol levels and apolipoprotein B (show APOB Antibodies) secretion and increased fatty acid oxidation.
Microsomal arylacetamide deacetylase competes against the activity of cytosolic arylamine N-acetyltransferase, which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens
arylacetamide deacetylase (esterase)
, arylacetamide deacetylase-like
, Arylacetamide deacetylase
, arylacetamide deacetylase
, arylacetamide deacetylase-like 2