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GTPase tethering membranes through formation of trans- homooligomer and mediating homotypic fusion of endoplasmic reticulum membranes.
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study reports that Sey1/Atl3 and Rtn4 (show RTN4 ELISA Kits) localize to early Legionella-containing vacuoles (LCV) and are critical for pathogen vacuole formation; Sey1/Atl3-dependent ER remodeling contributes to LCV maturation and intracellular replication of L. pneumophila
These results suggest that the three ATLs have different capacities to mediate endoplasmic reticulum fusion, with ATL1 being the strongest and ATL3 being the weakest.
ATL3 is implicated in the structural organization of intracellular organelles, which may be critical to axonal survival.
A family of human GTPases, atlastin-2 and -3 that are closely related to atlastin-1 are described.
Endoplasmic reticulum morphology is markedly disrupted in ATL1, ATL2, and ATL3 knockout cells.
GTPase tethering membranes through formation of trans- homooligomer and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis (By similarity).
atlastin GTPase 3
, atlastin 3