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This protein belongs to the basic helix-loop-helix (BHLH) family of transcription factors. Additionally we are shipping ATOH1 Proteins (9) and ATOH1 Kits (6) and many more products for this protein.
Showing 10 out of 149 products:
Human Polyclonal ATOH1 Primary Antibody for WB - ABIN1881085
Berman, Cheng, Dey: Not all body fat weighs equally in the acceleration of coronary artery disease. in JACC. Cardiovascular imaging 2010
Show all 3 Pubmed References
A genetic network of sensory determinant, Atoh1 (and Sox9a), play critical roles in otic neural development.
Sox2 (show SOX2 Antibodies) and Fgf interact with Atoh1 to promote sensory competence throughout the zebrafish inner ear.
Atoh1a expression must be restricted by Notch (show NOTCH1 Antibodies) signaling for effective morphogenesis of the posterior lateral line primordium in zebrafish.
in the zebrafish, two proneural genes are essential for differentiation of the hair cells, neuroD and atonal homolog 1
atoh1.2 and beta3.1 (show BHLHE22 Antibodies) are transcribed in distinct precursors.
Our results suggest that KN promotes goblet cell differentiation by regulating Wnt (show WNT2 Antibodies), Notch (show NOTCH1 Antibodies), and AhR (show AHR Antibodies) signals and expression of Hes1 (show HES1 Antibodies) and Hath1.
The authors discovered tyrosine 78 of Atoh1 is phosphorylated by a Jak2 (show JAK2 Antibodies)-mediated pathway only in tumor-initiating cells and in human Sonic Hedgehog (show SHH Antibodies)-type medulloblastoma.
ATOH1 expression was detected consistently in recurrent and metastatic SHH medulloblastoma. Chromatin immunoprecipitation sequencing and gene expression profiling identified candidate ATOH1 targets in tumor cells involved in development and tumorigenesis.
These data indicate that the regulation of Atoh1 by the ubiquitin proteasome pathway is necessary for hair cell fate determination and survival.
ATOH1 is increased in advanced Merkel cell carcinoma (MCC (show MCC Antibodies)) indicating that ATOH1 is involved in MCC (show MCC Antibodies) progression.
Study provides evidence that Sox2 (show SOX2 Antibodies) expression is required for the late stages of progenitor cell differentiation to hair cells and stimulates Atoh1 expression through a concentration dependent molecular interaction with the 3' enhancer of Atoh1.
Downregulation of Hath1 expression promoted the proliferation and reduced the apoptosis of KUMA5 squamous cell carcinoma cells.
ATOH1 can induce the differentiation of gastric cancer stem cells.
ATOH1 acts in concert with other transcription factors to directly regulate the cochlear hair cell phenotype.
Testosterone-bovine serum albumin (show ALB Antibodies) and Math1 treatment could promote an increase in hair-cell like cells in the lesser epithelial ridge through proliferation and transdifferentiation.
The results of this study presented here from various Atoh1 mutants demonstrate that neither peripheral nor central target cell differentiation is necessary for cochlear afferent segregation from vestibular afferents or for some degree of a cochleotopic segregation
Atoh1 function in hair cell differentiation is modulated by interaction with other transcription factors, such as Gfi1 (show ZNF163 Antibodies) and Pou4f3 (show POU4F3 Antibodies). (Review)
The data suggest that ErbB3 (show ERBB3 Antibodies) restricts Paneth cells numbers through PI3K-mediated suppression of Atoh1 levels leading to inhibition of Paneth cells differentiation, with important implications for regulation of the intestinal stem cells niche.
This study illustrates a SHH (show SHH Antibodies)-Stox1 (show STOX1 Antibodies)-Math1 regulatory axis in normal cerebellar development and medulloblastoma formation.
This work reveals a dynamic ATOH1-driven molecular cascade underlying medulloblastoma metastasis that offers possible therapeutic opportunities
The discovery that Atonal homolog 1 (Atoh1) governs the development of the sensory hair cells in the inner ear led to therapeutic efforts to restore these cells in cases of human deafness.
miR (show MLXIP Antibodies)-183 family expression in combination with Atoh1 not only appears to fine tune gene expression in favor of hair cells fate, but is also required for the expression of some hair cell-specific genes.
These data illuminate a genetic pathway that initiates auditory HC regeneration and suggest p27(Kip1 (show CDKN1B Antibodies)), GATA3 (show GATA3 Antibodies), and POU4F3 (show POU4F3 Antibodies) as additional therapeutic targets for ATOH1-mediated auditory hair cells regeneration.
Hes (show ATCAY Antibodies)/Hey signaling at the Atoh1 promoter has a role in selection of cell fate in the organ of Corti
This protein belongs to the basic helix-loop-helix (BHLH) family of transcription factors. It activates E-box dependent transcription along with E47.
, protein atonal homolog 1
, atonal homolog 1 (Drosophila)
, absent MD neurons and olfactory sensilla
, atonal homolog 1
, class A basic helix-loop-helix protein 14
, helix-loop-helix protein hATH-1
, helix-loop-helix protein mATH-1
, atonal 1